【摘要】： 目的:回顧性研究應(yīng)用不同誘導緩解方案及誘導緩解后應(yīng)用不同鞏固維持治療方案治療急性早幼粒細胞白血病(APL)的臨床療效,觀察應(yīng)用中醫(yī)藥分期辨證論治治療APL的臨床效果。 方法:回顧性分析遼寧中醫(yī)藥大學附屬醫(yī)院1999年-2007年收治的初治急性早幼粒細胞白血病病例21例,按照不同的誘導緩解治療方案比較各組的完全緩解率(CR)、達到CR的時間及復發(fā)例數(shù)和生存時間。 結(jié)果:21例初治患者中達到CR19例,死亡2例,總CR率89.5%。采用ATRA單誘導緩解方案治療的2例中,1例患者死亡,另一例獲得CR的時間為42.0d;采用As2O3單誘導緩解方案治療的10例中,第1療程達CR者2例,此組CR率為90.0%,獲得CR的平均時間為38.3d,死亡1例;采用ATRA+As2O3雙誘導緩解治療的9例中,第1療程達CR者5例,此組CR率為100%,獲得CR的平均時間為30.5d。 結(jié)論:對初發(fā)的APL患者,ATRA聯(lián)合As2O3雙誘導配合中醫(yī)藥分期辨證論治,可獲得較高的完全緩解率,獲得完全緩解的時間縮短,且獲得長期生存者多,無復發(fā)病例。
[Abstract]:Objective: to study the clinical efficacy of different induction remission regimens and different consolidation and maintenance regimens in the treatment of acute promyelocytic leukemia (APL). To observe the clinical effect of TCM syndrome differentiation in the treatment of APL. Methods: 21 cases of acute promyelocytic leukemia treated in affiliated Hospital of Liaoning University of traditional Chinese Medicine from 1999 to 2007 were analyzed retrospectively. the complete remission rate of (CR), in each group was compared according to different induced remission schemes. The time to reach CR, the number of recurrence cases and survival time. Results: of the 21 newly diagnosed patients, CR19 was achieved in 2 cases, and the total CR rate was 89.5%. Of the 2 cases treated with ATRA single induced remission regimen, 1 patient died and the other case obtained CR for 42.0 days. Of the 10 cases treated with As2O3 single induced remission regimen, 2 cases reached CR in the first course of treatment. The CR rate was 90.0%, the average time to obtain CR was 38.3 days, and 1 case died. Of the 9 cases treated with ATRA As2O3 double induction remission, 5 cases reached CR in the first course of treatment. The CR rate in this group was 100%, and the average time to obtain CR was 30.5 days. Conclusion: for patients with primary APL, ATRA combined with As2O3 double induction combined with syndrome differentiation of traditional Chinese medicine can obtain a higher complete remission rate, shorten the time to obtain complete remission, and obtain more long-term survival, no recurrence cases.
【學位授予單位】：遼寧中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2008
【分類號】：R733.7

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