中西醫(yī)結(jié)合預(yù)防造血干細(xì)胞移植后肝靜脈閉塞病的臨床觀察
[Abstract]:Objective to observe the preventive effect of compound salvia miltiorrhiza injection combined with prostaglandin E 1, low molecular weight heparin calcium and low molecular dextran on hepatic vein occlusion disease (hepatic veno-occlusive disease,HVOD) after hematopoietic stem cell transplantation. Methods from May 1998 to December 2009, 520 cases of hematopoietic stem cell transplantation were performed in our hospital, including 231 cases of autologous peripheral blood stem cell transplantation, 125 cases of HLA homozygous transplantation and 49 cases of unrelated HLA complete / incomplete transplantation. HLA haploidentical transplantation was performed in 115 cases. Compound salvia miltiorrhiza injection 40 ~ 60 mL, low molecular weight dextran 250 ~ 500 mL, prostaglandin E 140 ~ (60) 60 渭 g were given intravenously once a day, and low molecular weight heparin calcium 3000m ~ (5 000) IUU was subcutaneously injected once a day to observe the preventive effect on hepatic vein occlusive disease after hematopoietic stem cell transplantation. Results among the 520 patients, 1 case had HVOD and died, the incidence was 0.19. There was no obvious adverse drug reaction and no coagulation dysfunction. Conclusion compound salvia miltiorrhiza combined with prostaglandin E 1, low molecular weight heparin calcium and low molecular weight dextran can effectively prevent hepatic vein occlusion.
【作者單位】: 第三軍醫(yī)大學(xué)新橋醫(yī)院血液科;
【分類號(hào)】:R575;R457
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