天堂国产午夜亚洲专区-少妇人妻综合久久蜜臀-国产成人户外露出视频在线-国产91传媒一区二区三区

舌微循環(huán)變化與肺癌的相關(guān)性研究

發(fā)布時(shí)間:2018-09-10 10:24
【摘要】:目的:探討原發(fā)性支氣管肺癌患者的舌微循環(huán)變化規(guī)律,進(jìn)一步分析氣虛痰濕、陰虛毒熱、氣血瘀滯和氣陰兩虛四證型的肺癌患者舌微循環(huán)變化特點(diǎn),為肺癌的早期診斷、中醫(yī)辨證分型及治療提供客觀依據(jù)。 方法:參考第7版《內(nèi)科學(xué)》中肺癌診斷標(biāo)準(zhǔn),收集符合納入標(biāo)準(zhǔn)的河北醫(yī)科大學(xué)第四醫(yī)院(河北省腫瘤醫(yī)院)于2011.9-2012.10期間在呼吸科住院的140例原發(fā)性支氣管肺癌患者,按統(tǒng)一制定的觀察表詢問(wèn)患者情況。依據(jù)2002年版鄭筱萸主編的《中藥新藥研究指導(dǎo)原則》中肺癌中醫(yī)證型診斷標(biāo)準(zhǔn),將其分為氣虛痰濕證、陰虛毒熱證、氣血瘀滯證、氣陰兩虛證四個(gè)證型。采用XW-B-3型微循環(huán)顯微鏡檢查儀觀察舌微循環(huán)的變化,與30例正常人進(jìn)行比較。觀察項(xiàng)目包括:1微血管形態(tài):①微血管數(shù)、②輸入枝管徑、③輸出枝管徑;2乳頭狀態(tài):①上皮層厚度、②菌狀乳頭直徑;3管袢形態(tài):①管袢清晰度、②袢周異常;4血流狀態(tài):①虛線狀、②斷線狀;5微血管狀態(tài):①出血、②滲出,并探討四證型的變化特點(diǎn)。 結(jié)果: 1肺癌患者存在著明顯的舌微循環(huán)障礙,肺癌組患者的微血管數(shù)、上皮層厚度、管袢清晰度、袢周異常、血流狀態(tài)、微血管狀態(tài)與正常對(duì)照組比較均有顯著性差異(P0.01)。其主要表現(xiàn)為微血管數(shù)明顯減少;上皮層厚度變;管袢清晰度多見(jiàn)于模糊,占84.29%;袢周異常以痙攣和模糊的比例較多,分別占34.29%,22.86%;血流狀態(tài)以虛線狀和斷線狀為主,分別占45.0%,45.71%;微血管以出血和滲出為主,分別占42.14%,38.57%。 2不同證型的肺癌患者舌微循環(huán)變化有差異。其中氣虛痰濕組以菌狀乳頭直徑增粗,上皮層厚度增厚,袢周痙攣增多,占60.0%,微血管滲出增多,占73.33%,與其它三組比較均有顯著性差異(P0.05);陰虛毒熱組以微血管數(shù)增多,輸入枝管徑和輸出枝管徑增粗,血流狀態(tài)以斷續(xù)狀為主,占90.0%,與其它三組比較均有顯著性差異(P0.05);氣血瘀滯組以管袢及袢周模糊,微血管出血為特點(diǎn),管袢模糊增多,占96.87%,袢周模糊增多,占78.13%,微血管出血增多,占75.0%,與其它三組比較均有顯著性差異(P0.05);氣陰兩虛組的微血管數(shù)最少,輸入枝、輸出枝最細(xì)及菌狀乳頭直徑最短,上皮層厚度最薄,血流狀態(tài)以虛線狀最為明顯,占86.84%,與其它三組比較均有顯著性差異(P0.05)。 結(jié)論: 1肺癌患者存在明顯的微循環(huán)障礙,其機(jī)理可能是呼吸功能失常,宣降功能失調(diào),通調(diào)水道、輸布津液失職以及衛(wèi)外功能不固等生理功能失調(diào),導(dǎo)致末梢微循環(huán)發(fā)生障礙。主要表現(xiàn)為微血管數(shù)減少,上皮層厚度變薄,管袢模糊不清,袢周異常以痙攣和模糊的比例較多,血流狀態(tài)以虛線狀和斷線狀為主,微血管以出血和滲出為主。這為早期發(fā)現(xiàn)肺癌提供了參考指標(biāo)。 2不同證型的肺癌患者舌微循環(huán)變化有差異。氣虛痰濕組患者氣虛推動(dòng)無(wú)力,氣血津液運(yùn)行不暢,導(dǎo)致舌體中瘀血阻滯,津液停聚;氣虛無(wú)法統(tǒng)攝血液,使其不能在脈中正常運(yùn)行而溢出脈外;又痰濁水濕內(nèi)聚,氣機(jī)被遏,氣化失常,舌上皮層細(xì)胞變化減慢;痰阻經(jīng)絡(luò),經(jīng)脈拘攣,故以菌狀乳頭直徑增粗,上皮層厚度增加,袢周痙攣,微血管滲出最為明顯。陰虛毒熱組患者機(jī)體熱毒熏蒸,氣血運(yùn)行加快,舌表淺血流量增加,又陰液虧虛,血液難續(xù),故出現(xiàn)微血管數(shù)增多,輸入枝管徑、輸出枝管徑增粗,上皮層厚度變薄,流態(tài)以斷線狀為特點(diǎn)。氣血瘀滯組患者氣機(jī)阻滯,運(yùn)行不暢,水谷精微物質(zhì)輸布失常,又瘀血阻滯,血行不暢,舌體失養(yǎng);“瘀血不去,新血不生;瘀血不去,血不歸經(jīng)”,瘀血內(nèi)阻,,血液不循常道,溢出脈外,故以管袢及袢周模糊,微血管出血為特點(diǎn)。氣陰兩虛組患者氣虛推動(dòng)無(wú)力,陰虛血少,舌體失養(yǎng);陽(yáng)氣不能鼓動(dòng)血行,血液流速減慢;氣陰兩虛,舌體失養(yǎng),乳頭發(fā)育不良,故以輸入枝、輸出枝最細(xì)及菌狀乳頭直徑最短,上皮層厚度最薄,流態(tài)以虛線狀最為明顯。這可以更加深入了解肺癌的證型本質(zhì),為舌診微觀辨證研究提供參考依據(jù)。
[Abstract]:Objective: To explore the changes of tongue microcirculation in patients with primary bronchogenic carcinoma, and further analyze the characteristics of tongue microcirculation in lung cancer patients with Qi deficiency and phlegm dampness, Yin deficiency and toxic heat, Qi and blood stasis and deficiency of both qi and yin.
Methods: Referring to the diagnostic criteria of lung cancer in the 7th edition of Internal Medicine, 140 patients with primary bronchogenic carcinoma hospitalized in the Department of Respiratory Medicine in the Fourth Hospital of Hebei Medical University (Hebei Cancer Hospital) from September 2011 to October 2012 were enquired about according to the unified observation table. The diagnostic criteria of TCM syndromes of lung cancer were divided into four syndromes: deficiency of Qi and phlegm-dampness, deficiency of yin and toxin-heat, stagnation of Qi and blood, deficiency of both qi and yin. Number of vessel, diameter of input branch, diameter of output branch; 2 papillary state: 1 epithelial layer thickness, diameter of bacterial papilla; 3 loop shape: 1 loop clarity, 2 loop abnormality; 4 blood flow state: 1 dashed line, 2 broken line; 5 microvascular state: 1 hemorrhage, 2 exudation, and explore the changing characteristics of four syndrome types.
Result:
There were significant differences in the number of microvessels, epithelial layer thickness, loop clarity, abnormal periloop, blood flow status, and microvascular status between lung cancer patients and normal control group (P 0.01). The main manifestations were the decrease of the number of microvessels, the thinning of epithelial layer, and the loops clarity. The percentage of periloop abnormalities was 34.29% and 22.86% respectively; the blood flow was mainly dotted line and broken line, accounting for 45.0% and 45.71% respectively; the microvasculature was mainly hemorrhage and exudation, accounting for 42.14% and 38.57% respectively.
The changes of microcirculation of tongue in lung cancer patients with different syndromes were different. In Qi-deficiency and phlegm-dampness group, the diameter of papillae was enlarged, the thickness of epithelium was thickened, the spasm around the loop was increased, accounting for 60.0%, the microvascular exudation was increased, accounting for 73.33%, and there was significant difference compared with other three groups (P 0.05). The diameter of the outgoing branch was enlarged, and the blood flow was mainly intermittent, accounting for 90.0%, which was significantly different from the other three groups (P 0.05); in the Qi-blood stasis group, the loops and periloops were blurred, and the microvascular bleeding was characterized by 96.87%, 78.13% and 75.0% of the other three groups, respectively. Sex difference (P 0.05); Qi-Yin deficiency group had the least number of microvessels, input branches, output branches and the shortest diameter of bacterial papilla, the thinnest thickness of epithelial layer, the most obvious blood flow state was dotted line, accounting for 86.84%, compared with the other three groups had significant differences (P 0.05).
Conclusion:
1. There are obvious microcirculation disorders in lung cancer patients, which may be caused by respiratory dysfunction, dysfunction of propagating and lowering, dysfunction of regulating channels, dereliction of transfusion and distribution of fluid, and unstable external defense functions, leading to peripheral microcirculation disorders. There were more spasms and blurs, the blood flow was mainly dotted line and broken line, and the microvasculature was mainly bleeding and exudation.
The changes of tongue microcirculation in lung cancer patients with different syndromes were different.Qi deficiency and phlegm-dampness group had weak promotion of Qi deficiency,and the movement of Qi-blood and fluid was not smooth,which led to blood stasis in the tongue and the accumulation of body fluid.Qi deficiency could not control the blood and make it overflow the pulse. The changes of layer cells were slowed down; phlegm obstructed the channels and collaterals, and the channels were constrained, so the diameter of bacterial papillae was enlarged, the thickness of epithelial layer was increased, the spasm around the loop and the microvascular exudation was most obvious. In the Qi-blood stasis group, Qi-qi was blocked, the movement was not smooth, the blood transfusion was abnormal, and blood stasis was blocked, the blood flow was not smooth, and the tongue was dystrophic; "blood stasis did not go away, new blood did not grow; blood stasis did not go away, blood did not return to the meridian," blood stasis internal obstruction, blood stasis did not follow the normal path, overflow veins. The deficiency of both Qi and Yin group can not stimulate blood flow, blood flow rate is slowed down; deficiency of both Qi and Yin, tongue dystrophy, dysplasia of the nipple, so the input branch, output branch and the smallest diameter of bacterial papilla, epithelial layer thickness is the thinnest. The most obvious flow pattern is dotted line, which can help us to understand the nature of lung cancer and provide a reference for the study of microcosmic syndrome differentiation of tongue diagnosis.
【學(xué)位授予單位】:河北醫(yī)科大學(xué)
【學(xué)位級(jí)別】:碩士
【學(xué)位授予年份】:2013
【分類號(hào)】:R241.25;R273

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 趙煒;李佩文治療肺癌的經(jīng)驗(yàn)[J];北京中醫(yī);2002年06期

2 王禹堂,王笑民,郁仁存;癌癥患者的血瘀證研究[J];中國(guó)醫(yī)藥學(xué)報(bào);1996年06期

3 張志培,施新猷,張周良,邵秋菊,蔡壽興,周惠敏;食管癌患者甲襞微循環(huán)特點(diǎn)分析[J];第四軍醫(yī)大學(xué)學(xué)報(bào);2000年06期

4 林乾樹(shù),傅曉晴,李燦東,朱紅梅,唐?,周維湛;慢性胃炎舌微循環(huán)與證治關(guān)系研究[J];福建中醫(yī)學(xué)院學(xué)報(bào);1996年04期

5 張北玉;劉惠明;;燈盞花素對(duì)冠心病患者甲襞微循環(huán)及血液流變學(xué)的影響[J];廣東醫(yī)學(xué);2010年09期

6 李琳霈;;潘敏求主任醫(yī)師治療肺癌經(jīng)驗(yàn)[J];湖南中醫(yī)雜志;2007年05期

7 張晨;魏艾紅;;系統(tǒng)性紅斑狼瘡的舌尖微循環(huán)觀察[J];臨床軍醫(yī)雜志;2009年03期

8 趙征;黃烽;趙秀梅;;甲襞微循環(huán)在系統(tǒng)性硬化癥中的臨床意義及特點(diǎn)[J];軍醫(yī)進(jìn)修學(xué)院學(xué)報(bào);2009年01期

9 吳曉勇;伍賢鼎;曾文;李玲;胡昌蓉;;60例老年高血壓患者血液流變學(xué)與微循環(huán)變化的臨床觀察[J];檢驗(yàn)醫(yī)學(xué)與臨床;2009年18期

10 馬宗林,包力,劉翠霞,孫起文,喬惠瓏;脾虛證外周微循環(huán)對(duì)比觀察[J];遼寧中醫(yī)雜志;1995年10期

相關(guān)會(huì)議論文 前3條

1 陳群;王靜;路艷;余麗娟;;中醫(yī)舌診的現(xiàn)代研究概況[A];全國(guó)第十二次中醫(yī)診斷學(xué)術(shù)年會(huì)論文集[C];2011年

2 魏艾紅;肖景文;;白血病舌診[A];第七次全國(guó)中西醫(yī)結(jié)合四診研究學(xué)術(shù)會(huì)議論文匯編[C];2004年

3 劉曉偉;;腸易激綜合征中醫(yī)證候與舌微循環(huán)變化關(guān)系的探討[A];四診研究論文匯編[C];2000年

相關(guān)碩士學(xué)位論文 前2條

1 王曉f

本文編號(hào):2234176


資料下載
論文發(fā)表

本文鏈接:http://sikaile.net/yixuelunwen/zhxiyjh/2234176.html


Copyright(c)文論論文網(wǎng)All Rights Reserved | 網(wǎng)站地圖 |

版權(quán)申明:資料由用戶3a429***提供,本站僅收錄摘要或目錄,作者需要?jiǎng)h除請(qǐng)E-mail郵箱bigeng88@qq.com
国产日韩欧美综合视频| 色哟哟哟在线观看视频| 亚洲精品av少妇在线观看| 日韩在线一区中文字幕| 日韩精品一级一区二区| 99精品国产一区二区青青 | 国产亚洲精品香蕉视频播放| 日韩中文字幕狠狠人妻| 国内外免费在线激情视频| 国产日产欧美精品大秀| 中文日韩精品视频在线| 国产精品午夜福利免费阅读| 真实国产乱子伦对白视频不卡| 欧美日韩一级aa大片| 又黄又爽禁片视频在线观看| 欧美性猛交内射老熟妇| 国产精品午夜小视频观看| 国产又黄又爽又粗视频在线| 亚洲一区二区三区中文久久| 欧洲一级片一区二区三区| 国产日韩欧美国产欧美日韩| 精品国产一区二区欧美| 日韩夫妻午夜性生活视频| 九九热精品视频免费在线播放| 国产男女激情在线视频| 国产麻豆一区二区三区在| 午夜精品在线视频一区| 国产精品午夜福利在线观看| 中文字幕区自拍偷拍区| 国产精品免费视频视频| 亚洲欧美日本国产不卡| 日本黄色美女日本黄色| 国产精品一区二区视频成人| 久久热在线视频免费观看| 亚洲精品偷拍一区二区三区| 草草草草在线观看视频| 白丝美女被插入视频在线观看 | 国产a天堂一区二区专区| 日韩欧美黄色一级视频| 成人免费高清在线一区二区| 精品少妇人妻av免费看|