電針足三里和天樞穴對(duì)腸易激綜合征大鼠腦腸軸不同靶點(diǎn)的效應(yīng)差異
[Abstract]:Objective: to compare the regulatory effects of electroacupuncture at Zusanli and Tianshu on visceral Gao Min in (IBS) rats with irritable bowel syndrome, and to explore the different targets of the two points, and to provide experimental basis for further study on the specificity of acupoint effect. Methods: IBS animal model was established by acetic acid enema. The model rats were randomly divided into three groups: model group, electroacupuncture Zusanli group and electroacupuncture Tianshu group. Electroacupuncture two points group was stimulated by 20min electroacupuncture, once every other day, 7 times electroacupuncture treatment. To observe the effect of electroacupuncture on the behavior of visceral Gao Min in rats, and to detect the changes of neuropeptide Y (NPY) content at different targets in blood and brain and intestine of rats in each group. Results: compared with the model group, the volume threshold of abdominal lift and back arch was significantly increased in Zusanli group (P0.05). The content of NPY in thalamus of Zusanli group was significantly higher than that of Zusanli group (P 0.05). The content of NPY in colon tissue of Tianshu group was significantly higher than that of control group (P 0.05). Conclusion: Zusanli point has a direct and obvious inhibitory effect on visceral Gao Min and a significant regulatory effect on NPY in thalamus. The inhibitory effect of Tianshu point on visceral Gao Min was not obvious, and Tianshu point could only regulate the brain intestinal peptide disorder in colon area. It was speculated that the change of NPY content in thalamus might be the key regulatory substance of the difference between the two points.
【作者單位】: 北京中醫(yī)藥大學(xué)針灸推拿學(xué)院;
【基金】:國(guó)家重點(diǎn)基礎(chǔ)研究發(fā)展計(jì)劃(973計(jì)劃)(No.2012CB508506) 北京農(nóng)學(xué)院北京市重點(diǎn)實(shí)驗(yàn)室開(kāi)放性課題(No.TCVM201101)~~
【分類(lèi)號(hào)】:R245
【共引文獻(xiàn)】
相關(guān)博士學(xué)位論文 前10條
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