本文選題：穴位 + 磁刺激　； 參考：《河北工業(yè)大學(xué)》2013年博士論文

【摘要】：穴位是體表刺激到體內(nèi)神經(jīng)系統(tǒng)調(diào)控的切入點，，磁刺激技術(shù)因具有諸多不可比擬的優(yōu)勢而有望成為一種穴位新療法，但是目前磁刺激穴位的療效缺乏統(tǒng)一且合理的評定方法，還需進行深入探究。腦連接組學(xué)研究的逐步深入和復(fù)雜網(wǎng)絡(luò)理論的飛速發(fā)展為磁刺激穴位的研究開辟了新途徑。 本文利用復(fù)雜網(wǎng)絡(luò)分析方法，以內(nèi)關(guān)穴為例開展了基于高時間分辨率腦電的磁刺激穴位腦功能網(wǎng)絡(luò)的構(gòu)建與分析研究，旨在從整體性角度探索磁刺激穴位對大腦功能連接的影響，為穴位磁刺激的作用效應(yīng)評價提供新手段，尤其為精神類等疾病的臨床康復(fù)治療效果評價提供新思路。本文主要研究內(nèi)容如下： 1、設(shè)計并開展了不同頻率磁刺激穴位和非穴位不同階段的腦電采集實驗，采用互相關(guān)和互信息方法對不同狀態(tài)下高分辨率的腦電信號進行了多通道關(guān)聯(lián)特性分析，結(jié)果發(fā)現(xiàn)3Hz磁刺激內(nèi)關(guān)穴時腦功能連接增強的趨勢較為明顯。 2、基于磁刺激穴位的多通道腦電信號關(guān)聯(lián)特性矩陣構(gòu)建了無權(quán)和加權(quán)腦功能網(wǎng)絡(luò)，并對網(wǎng)絡(luò)特征量進行了深入分析，結(jié)果發(fā)現(xiàn)3Hz磁刺激內(nèi)關(guān)穴時腦功能網(wǎng)絡(luò)連接邊、平均度、平均聚類系數(shù)和全局效率顯著增加，平均路徑長度顯著降低。磁刺激非穴位時腦功能網(wǎng)絡(luò)特征量的變化明顯小于穴位刺激引起的變化。 3、對磁刺激穴位的無權(quán)和加權(quán)腦功能網(wǎng)絡(luò)進行了中心度和中心化程度分析，結(jié)果發(fā)現(xiàn)3Hz磁刺激內(nèi)關(guān)穴時額葉、中央?yún)^(qū)以及頂葉大部分節(jié)點的度中心度和緊密中心度明顯升高，頂葉和中央?yún)^(qū)部分節(jié)點的介數(shù)中心度明顯減小。磁刺激非穴位時腦功能網(wǎng)絡(luò)中心度的變化明顯小于穴位刺激引起的變化。 4、對磁刺激穴位的腦功能網(wǎng)絡(luò)進行了“小世界”屬性評價，結(jié)果發(fā)現(xiàn)所有被試不同刺激階段的腦功能網(wǎng)絡(luò)均具有“小世界”屬性，3Hz磁刺激內(nèi)關(guān)穴時腦功能網(wǎng)絡(luò)的“小世界”屬性顯著增強。磁刺激非穴位時腦功能網(wǎng)絡(luò)“小世界”屬性的變化小于穴位刺激引起的變化。
[Abstract]:Acupoint is the cut-in point from body surface stimulation to internal nervous system regulation. Magnetic stimulation technology is expected to become a new therapy for acupoints because of its incomparable advantages. However, at present, there is no uniform and reasonable evaluation method for the effect of magnetic stimulation on acupoints. Further research is needed. The rapid development of the theory of complex network and the study of brain connectionology have opened up a new way for the study of magnetic stimulation acupoints. In this paper, using the complex network analysis method, taking Neiguan point as an example, the construction and analysis of the functional network of magnetic stimulation acupoint based on high-resolution EEG are carried out. The purpose of this study is to explore the effect of magnetic stimulation on the functional connections of the brain from a holistic point of view, and to provide a new method for the evaluation of the effect of magnetic stimulation at acupoints, especially for the evaluation of the effect of clinical rehabilitation therapy for mental diseases. The main contents of this paper are as follows: 1. The EEG sampling experiments of different frequency magnetic stimulation points and non-acupoints were designed and carried out. The multi-channel correlation characteristics of high-resolution EEG signals in different states were analyzed by cross-correlation and mutual information methods. The results showed that 3Hz magnetic stimulation of Neiguan point showed an obvious tendency of enhancement of brain functional connections. 2. Based on the multi-channel EEG correlation characteristic matrix of magnetic stimulation acupoints, the weighted and unweighted brain function network was constructed, and the characteristic quantity of the network was analyzed in depth. The results showed that the brain function network connected edge and average degree when 3Hz magnetic stimulation at Neiguan point. The average clustering coefficient and global efficiency increased significantly, and the average path length decreased significantly. The change of the characteristic quantity of brain function network in magnetic stimulation was obviously smaller than that caused by acupoint stimulation. 3. The degree of centrality and centralization of weighted and unweighted brain function network of magnetic stimulation acupoints were analyzed. The results showed that the degree of centrality and dense centrality of frontal lobe, central region and most nodes of parietal lobe were significantly increased by 3Hz magnetic stimulation at Neiguan point. The centroid of some nodes in parietal lobe and central region decreased obviously. The change of cerebral functional network centrality in magnetic stimulation was significantly smaller than that induced by acupoint stimulation. 4. The "small world" attribute of the brain function network of magnetic stimulation acupoints was evaluated. The results showed that all the brain functional networks at different stimulation stages had the "small world" attribute. The "small world" attribute of the brain functional network was significantly enhanced when the Neiguan acupoint was stimulated with 3Hz magnetic stimulation. The change of the "small world" attribute of brain function network is smaller than that caused by acupoint stimulation when magnetic stimulation is non-acupoint.
【學(xué)位授予單位】：河北工業(yè)大學(xué)
【學(xué)位級別】：博士
【學(xué)位授予年份】：2013
【分類號】：R245

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