本文選題：急性一氧化碳中毒 + 遲發(fā)性腦病��； 參考：《遼寧中醫(yī)雜志》2008年07期

【摘要】：目的:研究急性一氧化碳中毒患者血漿溶血磷脂酸變化與病情嚴(yán)重程度的相關(guān)性,血漿溶血磷脂酸水平對急性一氧化碳中毒患者發(fā)生遲發(fā)型腦病的預(yù)警作用,探討對血漿溶血磷脂酸升高早期干預(yù)防止遲發(fā)型腦病的可行性。方法:204例急性一氧化碳中毒患者,入院后分為輕、中、重度中毒,均于入院后24h內(nèi)采集靜脈血測定血漿溶血磷脂酸,觀察血漿溶血磷脂酸水平與病情嚴(yán)重程度的關(guān)系。隨訪至發(fā)病后60天,觀察不同血漿溶血磷脂酸水平發(fā)生遲發(fā)性腦病的比例。對血漿溶血磷脂酸升高者隨機(jī)分為觀察Ⅰ組、觀察Ⅱ組,觀察Ⅱ組采用常規(guī)治療,觀察Ⅰ組加奧扎格雷、醒腦靜靜脈點(diǎn)滴,對比兩組發(fā)生遲發(fā)性腦病的比例。結(jié)果:(1)急性一氧化碳中毒患者輕度中毒血漿溶血磷脂酸無明顯變化,中度中毒血漿溶血磷脂酸輕中度升高,重度中毒明顯升高,組間有顯著差異;(2)血漿溶血磷脂酸正常者無遲發(fā)性腦病發(fā)生,輕度異常者1例發(fā)生遲發(fā)性腦病,中度異常者無遲發(fā)性腦病,重度中毒者21例發(fā)生遲發(fā)性腦病。組間有顯著差異;(3)對血漿溶血磷脂酸升高者121例分為兩組,觀察Ⅰ組發(fā)生遲發(fā)性腦病6例,觀察Ⅱ組發(fā)生遲發(fā)性腦病20例,組間有顯著差異。結(jié)論:急性一氧化碳中毒中重度患者存在血栓前狀態(tài),血漿溶血磷脂酸升高與病情嚴(yán)重程度呈正相關(guān),可作為判斷急性中毒患者病情嚴(yán)重程度的指標(biāo),血漿溶血磷脂酸升高程度與發(fā)生遲發(fā)性腦病的危險(xiǎn)性呈正相關(guān),可作為發(fā)生遲發(fā)性腦病的預(yù)警標(biāo)記物。對血漿溶血磷脂酸升高者早期干預(yù)可明顯減少遲發(fā)性腦病的發(fā)生。
[Abstract]:Objective: to study the relationship between the changes of plasma lysophosphatidic acid and the severity of acute carbon monoxide poisoning, and the early warning effect of plasma lysophosphatidic acid level on delayed encephalopathy in patients with acute carbon monoxide poisoning. To explore the feasibility of early intervention on plasma lysophosphatidic acid elevation to prevent delayed encephalopathy. Methods 204 patients with acute carbon monoxide poisoning were divided into mild, moderate and severe poisoning. Venous blood samples were collected within 24 hours after admission for determination of plasma lysophosphatidic acid, and the relationship between plasma lysophosphatidic acid level and severity of the disease was observed. The rate of delayed encephalopathy in different plasma lysophosphatidic acid levels was observed after 60 days follow-up. Patients with elevated plasma lysophosphatidic acid were randomly divided into observation group 鈪，

本文編號(hào)：1901675