本文選題：老年急性髓系白血病 + 中西醫(yī)結(jié)合　； 參考：《中國(guó)中西醫(yī)結(jié)合雜志》2017年09期

【摘要】：目的回顧性分析中西醫(yī)個(gè)體化分層治療老年急性髓系白血病(AML)的臨床療效和不良反應(yīng)。方法采用回顧性研究方法,根據(jù)患者合并的基礎(chǔ)疾病、體力狀態(tài)(ECOG)評(píng)分、治療方法將54例老年AML患者分為A組(扶正祛邪方加減+標(biāo)準(zhǔn)劑量化療組,19例)、B組(扶正祛邪方加減+減低劑量化療組,18例)、C組(扶正祛邪方加減姑息治療組,17例),分析患者骨髓緩解率、生存時(shí)間、中醫(yī)證候療效和不良反應(yīng)。結(jié)果54例患者緩解率為68.5%(37/54),平均生存時(shí)間為(12.9±6.0)個(gè)月,中位生存時(shí)間為13個(gè)月,1年及以上生存率為55.6%(30/54),中醫(yī)證候總有效率為83.3%(45/54),患者出現(xiàn)感染、胃腸道反應(yīng)、心臟毒性、肝腎毒性的發(fā)生率分別為25.9%(14/54)、16.7%(9/54)、11.1%(6/54)、7.4%(4/54)。除中醫(yī)證候療效外,C組其余指標(biāo)均低于A、B組(P0.05)。結(jié)論中西醫(yī)個(gè)體化分層方案可提高老年AML臨床療效,減少不良反應(yīng)的發(fā)生,提高生存質(zhì)量,增加遠(yuǎn)期療效。
[Abstract]:Objective to analyze the clinical efficacy and adverse effects of individualized stratification of traditional Chinese and western medicine in the treatment of elderly patients with acute myeloid leukemia (AML). Methods A retrospective study was conducted to evaluate the patients' underlying diseases, physical status and ECOG scores. 54 elderly patients with AML were divided into two groups: group A (Fuzheng Quxie decoction plus or minus standard dose chemotherapy group, n = 19 cases, group B) (group A, n = 18) with Fuzheng Quxie decoction plus or minus reducing dose chemotherapy group, group C (Fuzheng Quxie decoction plus or minus palliative treatment group, n = 18, n = 18). Analysis of bone marrow remission rate, Survival time, TCM syndrome efficacy and adverse reactions. Results the remission rate of 54 patients was 68.5% 37 / 54, the average survival time was 12.9 鹵6.0 months, the median survival time was 13 months, the survival rate of one year and more was 55.60.54%, the total effective rate of TCM syndrome was 83.30.45r54%, the patients had infection, gastrointestinal reaction, cardiac toxicity. The incidence of hepatorenal toxicity was 25. 9 / 14 / 54 / 16. 7 / 11. 6 / 54 / 7. 4 / 54. The other indexes of group C were lower than that of group A B (P 0.05) except the curative effect of TCM syndromes. Conclusion individualized stratification of traditional Chinese and western medicine can improve the clinical efficacy of AML, reduce the occurrence of adverse reactions, improve the quality of life, and increase the long-term efficacy.
【作者單位】： 天津中醫(yī)藥大學(xué)第一附屬醫(yī)院血液科;天津中醫(yī)藥大學(xué)研究生院;
【基金】：天津市應(yīng)用基礎(chǔ)及前沿技術(shù)研究計(jì)劃重點(diǎn)資助項(xiàng)目(No.12JCZDJC25400)
【分類(lèi)號(hào)】：R733.71
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本文編號(hào)：1874715