本文選題：中西醫(yī)結(jié)合　切入點：強直性脊柱炎　出處：《青島大學(xué)》2017年碩士論文

【摘要】：目的探討中草藥聯(lián)合西藥治療強直性脊柱炎的臨床療效,為中西醫(yī)結(jié)合治療強直性脊柱炎提供科學(xué)依據(jù)。方法選取我院2010年1月至2015年12月期間收住院治療的76例強直性脊柱炎患者的臨床資料進(jìn)行了回顧性研究,用統(tǒng)計學(xué)方法加以分析。根據(jù)患者給藥治療方式的差異,將其分為治療組(n=38)和對照組(n=38)。對照組患者采取西醫(yī)常規(guī)治療,治療組患者在西醫(yī)常規(guī)治療基礎(chǔ)上加中醫(yī)辨證治療。首先,根據(jù)患者的實際病情而定,將其劃分為腎陰虛型與腎陽虛型兩型,對分別進(jìn)行針對性的治療。對照組患者以西醫(yī)常規(guī)行治療(患者以口服柳氮磺胺吡啶+甲氨蝶呤的形式進(jìn)行治療,其中柳氮磺胺吡啶第一周每次用量為1片,用藥頻率為每日3次,往后以每周遞增2片的用量逐次增長,每次用量最多不超過4片;甲氨蝶呤第一周每次用量為2片,用藥頻率為每周1次,往后用藥劑量改為每周3片,用藥頻率不變。),給予患者以口服的形式進(jìn)行治療,治療組在對照組患者的治療基礎(chǔ)上,另外對對照組患者進(jìn)行中醫(yī)辨證治療。收集治療前、后患者的BASFI(Bath強直性脊柱炎患者功能指數(shù))、BASDAI(Bath強直性脊柱炎患者病情活動指數(shù))、CRP(超敏C反應(yīng)蛋白)、ESR(紅細(xì)胞沉降率)及總有效率等有關(guān)指標(biāo)進(jìn)行比較,用統(tǒng)計學(xué)方法給以分析,從而得出結(jié)論。結(jié)果研究組和對照組患者的、性別、年齡等基本信息無顯著性差異(P0.05),具有可比性。對照組經(jīng)過治療后,BASFI、BASDAI、ESR、CRP等指標(biāo)明顯較治療前好轉(zhuǎn),治療組患者的各項指標(biāo)BASFI、BASDAI、ESR、CRP比對照組患者的指標(biāo)明顯較優(yōu),存在明顯差異,具有統(tǒng)計學(xué)意義(P0.05);治療組取得的總有效率(94.74%)明顯高于對照組(76.32%)。兩種治療方案均有明顯臨床療效,治療組方案更優(yōu)。結(jié)論治療組患者(中藥與西藥聯(lián)合)經(jīng)治療后結(jié)果,BASFI、BASDAI、ESR、CRP及總有效率等相關(guān)指標(biāo),均明顯優(yōu)于對照組患者(實施西醫(yī)治療)。以中草藥聯(lián)合西藥的方法治療強直性脊柱炎,可緩解病情,有助于改善患者的生活質(zhì)量。
[Abstract]:Objective to investigate the clinical effect of Chinese herbal medicine combined with western medicine in the treatment of ankylosing spondylitis. Methods the clinical data of 76 patients with ankylosing spondylitis admitted in our hospital from January 2010 to December 2015 were retrospectively studied. According to the difference of the treatment methods, the patients were divided into two groups: the treatment group and the control group. The patients in the control group were treated with routine western medicine, and the patients in the control group were treated with routine western medicine. The patients in the treatment group were treated with TCM syndrome differentiation on the basis of routine western medicine treatment. First of all, according to the actual condition of the patients, they were divided into two types: kidney yin deficiency type and kidney yang deficiency type. The patients in the control group were treated with routine western medicine (the patients were treated with oral salbutamidepyridine methotrexate, in which 1 tablet was used for the first week. The dosage of methotrexate in the first week was 2 tablets each time, the frequency of medication was 1 time per week, and the dosage was changed to 3 tablets per week after the use of methotrexate was 3 tablets per week, the dosage of methotrexate was 3 tablets per week, and the dosage of methotrexate was 3 tablets per week. The treatment group was treated by oral administration. On the basis of the treatment of the patients in the control group, in addition, the patients in the control group were treated with TCM syndrome differentiation. Before the collection and treatment, The functional index of patients with BASFI(Bath ankylosing spondylitis was compared with that of the patients with BASFI(Bath ankylosing spondylitis. The relative indexes such as erythrocyte sedimentation rate (erythrocyte sedimentation rate) and total effective rate of patients with BASFI(Bath ankylosing spondylitis were compared and analyzed by statistical method. Results there was no significant difference in the basic information of sex and age between the study group and the control group (P 0.05), which was comparable. The indexes of ESRCRP in the control group were significantly better than those before treatment, after treatment, there was no significant difference in sex and age between the study group and the control group, and there was no significant difference in the basic information between the study group and the control group (P 0.05). The indexes of the patients in the treatment group were significantly better than those in the control group (P 0.05), and the total effective rate in the treatment group was 94.74% higher than that in the control group (76.32%). Conclusion the results of the treatment group (combination of traditional Chinese medicine and western medicine) after the treatment of the results of the treatment of BASFIX BASDAIK ESRR CRP and the total effective rate and other related indicators, The treatment of ankylosing spondylitis with Chinese herbal medicine combined with western medicine can alleviate the condition and help to improve the quality of life of the patients.
【學(xué)位授予單位】：青島大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R593.23

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