發(fā)布時間：2018-03-05 14:07

  本文選題：雄激素源性脫發(fā)　切入點(diǎn)：中西醫(yī)結(jié)合　出處：《廣州中醫(yī)藥大學(xué)》2009年碩士論文　論文類型：學(xué)位論文

【摘要】： 研究目的: 探討以“生發(fā)湯”為基礎(chǔ)的中藥復(fù)方結(jié)合西藥非那雄胺、米諾地爾對雄激素性脫發(fā)的治療效果。 研究方法: 本研究為前瞻性研究,采用半隨機(jī)對照法。 本研究選擇廣州中醫(yī)藥大學(xué)第一附屬醫(yī)院皮膚科門診就診的男性脫發(fā)患者。共92例,分為3組。治療組40例,予口服“生發(fā)湯”(女貞子30g、旱蓮草30g、何首烏15g、菟絲子15g、桑寄生15g、丹參30g、田七10g、黃芪30g、茯苓15g,炙甘草10g),結(jié)合辨證加減治療,同時口服非那雄胺;西藥對照組25例,予口服非那雄胺;中藥對照組27例,予口服“生發(fā)湯”(如治療組)。三組均同時外用米諾地爾。分別觀察治療3個月、6個月后脫發(fā)改善及生發(fā)情況,及頭發(fā)油膩、頭癢及頭屑數(shù)量三個伴隨癥狀的改善情況,并記錄治療過程中發(fā)生的不良反應(yīng)。 研究結(jié)果: 三組患者的年齡、病程和脫發(fā)程度比較,均無顯著性差異,具有可比性。治療3個月及6個月后頭皮油膩、瘙癢、頭屑數(shù)量程度改善情況比較,治療組均明顯優(yōu)于西藥對照組,差異具有統(tǒng)計(jì)學(xué)意義(P＜0.05),而治療組與中藥對照組則改善情況比較接近,差異無統(tǒng)計(jì)學(xué)意義(P＞0.05),西藥對照組改善情況差于中藥對照組(P＜0.05)。在臨床療效方面,治療3個月后治療組明顯優(yōu)于兩對照組,差異有統(tǒng)計(jì)學(xué)意義(P＜0.05),而西藥對照組則優(yōu)于中藥對照組(P＞0.05);經(jīng)過6個月治療,治療組仍然明顯優(yōu)于兩對照組,但西藥對照組與中藥對照組療效接近(P＞0.05)。治療組內(nèi)部,治療組脫發(fā)分型、病程與臨床療效具有相關(guān)性(P＞0.05)。 三組均未出現(xiàn)性功能減退。治療組及中藥對照組患者經(jīng)治療后多訴自覺身體狀況明顯好轉(zhuǎn),包括精力較前旺盛,睡眠、飲食等質(zhì)量明顯提高,而西藥對照組未見患者有該方面的反饋。中藥組有1例(3.70%)使用米諾地爾一周后,出現(xiàn)頭皮癢,紅,停藥2周再繼續(xù)使用未見不適。 研究結(jié)論: 研究結(jié)果證明,中藥治療雄激素源性脫發(fā)療效確切,安全性好。在起效時間、治療效果、改善伴隨癥狀方面,治療組均優(yōu)于對照組,且隨著治療療時間延長,治療效果更為明顯增加。說明中西醫(yī)結(jié)合治療本病比單用西藥或中藥臨床效果更好,既可顯著提高患者的生活質(zhì)量,又可顯著提高療效。
[Abstract]:Objectives of the study:. To explore the therapeutic effect of traditional Chinese medicine prescription combined with western medicine finasteride and minodil on androgen alopecia based on "Shengfa decoction". Research methods:. This study is a prospective study, using a semi-randomized controlled method. In this study, 92 male patients with alopecia were selected from the dermatology department of the first affiliated Hospital of Guangzhou University of traditional Chinese Medicine. They were divided into three groups: treatment group (n = 40), treatment group (n = 40). "Shengfa decoction" (30 g Ligustrum lucidum, 30 g drought lotus grass, 15 g Polygonum multiflorum, 15 g Cuscuta, 15 g mulberry parasitism, 30 g Salvia miltiorrhiza, 10 g Tianqi, 30g Astragalus membranaceus, 15g Poria cocos, 10g grilled licorice 10g) was given orally. The Chinese medicine control group (27 cases) was given orally "Shengfa decoction" (such as the treatment group). All the three groups were treated with minodil at the same time. After 3 months of treatment, 6 months after treatment, the alopecia and hair growth were improved, and the hair was greasy. The three associated symptoms of scalp itching and dandruff quantity were improved and adverse reactions during treatment were recorded. Results of the study:. There was no significant difference in age, course of disease and degree of alopecia among the three groups. After 3 and 6 months of treatment, the degree of greasy scalp, pruritus and quantity of dandruff were improved. The treatment group was significantly better than the western medicine control group, the difference was statistically significant (P < 0.05), while the improvement of the treatment group and the traditional Chinese medicine control group was similar. There was no significant difference (P > 0.05). The improvement of the western medicine control group was worse than that of the traditional Chinese medicine control group (P < 0.05). In the clinical effect, the treatment group was better than the two control groups after 3 months of treatment. The difference was statistically significant (P < 0.05), while that of the western medicine control group was better than that of the traditional Chinese medicine control group (P > 0.05). After 6 months of treatment, the treatment group was still significantly better than the two control groups, but the curative effect between the western medicine control group and the traditional Chinese medicine control group was similar to that of the traditional Chinese medicine control group (P > 0.05). There was a correlation between the course of disease and the clinical curative effect (P > 0.05). After treatment, the patients in the treatment group and the traditional Chinese medicine control group reported that their physical condition was obviously improved, including the improvement of energy, sleep, diet and so on. In the western medicine control group, there was no feedback from the patients. In the Chinese medicine group, one case was treated with minodil for one week, the scalp was itchy, red, and the drug was stopped for 2 weeks. The study concluded that:. The results showed that the treatment of androgen-derived alopecia was effective and safe. The treatment group was superior to the control group in terms of onset time, therapeutic effect and improvement of accompanying symptoms, and the treatment group was superior to the control group in terms of the onset time, the therapeutic effect and the improvement of accompanying symptoms. The therapeutic effect is more obvious. It shows that the combination of traditional Chinese and western medicine is more effective than western medicine or traditional Chinese medicine alone in the treatment of this disease, which can improve the quality of life of the patients and improve the curative effect.
【學(xué)位授予單位】：廣州中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2009
【分類號】：R758.71

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