背景:非酒精性脂肪肝病（non-alcoholic fatty liver disease,NAFLD）是以肝實質(zhì)細胞脂肪變性、脂肪貯積和炎癥反應為主要特征,并且無過量飲酒史的慢性肝臟代謝性疾病。NAFLD從單純性脂肪肝、可發(fā)展成為非酒精性脂肪性肝炎（non-alcoholic steatohepatitis,NASH）、肝纖維化、肝硬化、甚至肝癌。NAFLD的發(fā)病率、死亡率逐年升高,并呈低齡化發(fā)病趨勢。盡管目前對NAFLD發(fā)病機制的研究取得了一定的進展,但仍然缺乏有效的治療藥物。因此,尋找對NAFLD有效的治療藥物就顯得尤其關(guān)鍵。黃芩苷（Baicalin,BA）是一種具有抗炎、抗氧化、調(diào)血脂、免疫調(diào)節(jié)等多種藥理作用的黃酮類化合物。研究發(fā)現(xiàn)黃芩苷對多種原因引起的肝臟損傷有一定的保護作用。目的:探討黃芩苷及其納米脂質(zhì)體對小鼠非酒精性脂肪肝病的保護作用及可能的作用機制。方法:1.黃芩苷納米脂質(zhì)體的制備及表征鑒定以卵磷脂、膽固醇為膜材料,采用薄膜分散法制備黃芩苷納米脂質(zhì)體,并考察其微觀形態(tài)、粒徑分布、多分散系數(shù)、Zeta電位值、包封率和載藥量。2.黃芩苷納米脂質(zhì)體對NAFLD小鼠的保護作用將... 

【文章來源】：重慶醫(yī)科大學重慶市

【文章頁數(shù)】：72 頁

【學位級別】：碩士

【部分圖文】：

黃芩苷結(jié)構(gòu)式Fig1.ThemolecularstructuralformulaofBaicalin

圖 2. 黃芩苷納米脂質(zhì)體透射電鏡圖Transmission electron micrograph image o體的粒徑分布、多分散系數(shù)和苷納米脂質(zhì)體平均粒徑為 81.41 nm

圖 2. 黃芩苷納米脂質(zhì)體透射電鏡圖Fig 2. Transmission electron micrograph image of BA-NL苷納米脂質(zhì)體的粒徑分布、多分散系數(shù)和 Zeta 電位 3 所示，黃芩苷納米脂質(zhì)體平均粒徑為 81.41 nm，多分散系數(shù)值為-13.9 ± 5.74 mV。

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