飛行員冠心病危險(xiǎn)因素分析及LOX-1基因多態(tài)性與飛行員冠心病的關(guān)系研究
文內(nèi)圖片:
圖片說明:LOX-1在動(dòng)脈粥樣硬化發(fā)生發(fā)展過程中的作用注:示LOX-1的作用點(diǎn)
[Abstract]:Background: In flight personnel, coronary heart disease and myocardial infarction occur frequently, which is a serious threat to flight safety, which may lead to a sudden loss of air in the air of the pilot The most important pathological factors of myocardial infarction in coronary heart disease are the stenosis of the vascular lumen caused by coronary atherosclerosis, and the cause of atherosclerosis is not yet completely clear, and a large number of studies have shown that atherosclerosis has a direct relationship with a variety of risk factors and is made in various risk factors. With the use of lower and arterial endothelial damage, endothelial dysfunction is caused, and atherosclerosis is gradually formed. The prevention and treatment of coronary heart disease can only comprehensively improve the multi-factor risk spectrum, so that the risk can be reduced greatly, so the control risk factors are the prevention of coronary heart disease. The study shows that at least 80% of the risk of coronary heart disease in men from 35 to 59 years of age can be attributed to hyperlipidemia, hypertension, and smoking. Factors: The distribution of the risk factors of coronary heart disease in our pilot population is different from that of the general population. The role of another genetic factor in the occurrence of coronary heart disease is not to be ignored. At present, many studies have detected the gene polymorphism and the myocardial infarction of coronary heart disease. The relationship. Hemagglutinin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is first discovered by Japanese scholars in 1997, and is the specificity of oxidized low-density lipoprotein (ox-LDL). The receptor. LOX-1 is expressed in the vascular endothelial cells, macrophages, vascular smooth muscle cells, fibroblasts and platelets, and is expressed in the pathological conditions of hypertension, diabetes, and hyperlipidemia to promote the occurrence of atherosclerosis. An increase in the presence of high in atherosclerotic plaques Expression of LOX-1 gene 3-UUTR C/ T polymorphism and the risk of atherosclerosis and acute myocardial infarction It is related to whether the polymorphism of LOX-1 gene in our pilots is related to the occurrence of coronary heart disease, and whether the risk factors of other coronary heart diseases such as the level of blood lipid and other coronary heart disease have yet to be Research. Objective:1. To investigate the risk factors of coronary heart disease in the flight personnel of our army, and to analyze the risk factors of coronary heart disease in pilots. Is there a difference in the population;2. Test the pilot LOX-1 gene 3. The Study of the Polymorphism of the UTR C/ T and the Study on the Polymorphism of LOX-1 and the Caps of the Pilots heart disease and heart disease The relationship between the risk factors and the risk factors. Methods:1. The questionnaire of the risk factors of coronary heart disease of pilots was established. The general condition and health status of 297 pilots were investigated by the method of current status survey. The risk factors of coronary heart disease were analyzed in this paper. u-test, one-factor analysis of variance and L-test were used. the statistical analysis was carried out by the logistic regression analysis;2, real-time fluorescence was applied A case-control study was used to detect the polymorphism of LOX-1 gene in 20 pilots and 20 healthy control pilots confirmed by coronary angiography as coronary atherosclerosis and to compare the distribution of the gene polymorphism in the two groups. and the correlation between the polymorphism of the gene and the coronary heart disease and the risk factors system Results: The proportion of risk factors of coronary heart disease (CHD), such as smoking, drinking, bad diet, overweight, dyslipidemia, hypertension, and diabetes, were 62.63%, 60.94% and 48.82%, respectively. 38.72%, 26.60%, 10.44%,3 In the age group of 35 to 44, smoking and drinking are the highest. The risk factors of the coronary heart disease of the pilot are different from those of the men over the age of 20 years in China. Smoking, alcohol consumption, overweight The incidence of dyslipidemia is high, and the prevalence of hypertension and diabetes is low. The multivariate logistic regression analysis shows that the risk factors for coronary heart disease include: the age of over 45 years, the history of hypertension, family history of coronary heart disease, smoking more than 200 years, TC level of more than 6.22 mmol/ l and HDL lower than 1.04 mmol/ l, the odds ratio (OR) value is the highest (OR) value at an age of more than 45 years ( (12.78), followed by smoking for more than 200 years (10.12). A total of 297 pilots were grouped according to the amount of smoking, and the level of blood lipids in each of the smoking groups was compared, and the level of serum TC, TG, LDL-C, TC/ HDL-C was significantly higher than that of non-smoking group and less than 100 in the non-smoking group. in that support group, the level of HDL-C was significantly lower than the lat (p? 0.05).2. LOX-1 gene 3 in the pilot we observed The frequency of T allele in the pilot of the case group was higher than that of the control group (0.50 vs.275, p? 0.05) and the CT + TT genotype in the case of age, time of flight, smoking rate, blood fat, and homocysteine. The frequency was also significantly higher in the control group (0.80 vs. 0.50, p? 0.05), and the other by the genotype group, TC, TG, HD L,L There was no significant difference in the indexes of DL, smoking and Hcy (p.05). Conclusion: 1. There is a wide range of risk factors of coronary heart disease among our pilots, among which the proportion of smoking is the most. The risk factors of the coronary heart disease in pilots are similar to those of the men in the normal age of 20 years in China. The incidence of smoking, drinking, overweight and dyslipidemia is high, and the prevalence of hypertension and diabetes is low. The factors associated with the coronary heart disease of pilots are mainly of the age of over 45 years, the history of hypertension, family history of coronary heart disease, and smoking more than 200 years. with a total cholesterol level of more than 6.22 mmol/ l, HD, "L is lower than 1.04 mmol/ l.2, and smoking is one of the factors leading to the abnormal blood lipid metabolism of the pilot.3. The polymorphism of LOX-1 gene is related to the coronary heart disease of the pilot. The variant genotype (CT + TT) of LOX-1 gene may be related to the coronary heart disease of the pilot. Risk-related, T-allele carriers may have a higher risk of disease, but the LOX-1 gene polymorphism is associated with coronary heart disease such as smoking, blood lipid, and Hcy.
【學(xué)位授予單位】:第四軍醫(yī)大學(xué)
【學(xué)位級(jí)別】:碩士
【學(xué)位授予年份】:2008
【分類號(hào)】:R541.4;R85
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