發(fā)布時間：2019-06-04 11:17

【摘要】：目的 探討軍隊老年人阿爾茨海默病(AD)的危險因素,初步分析早年電磁暴露與AD的關系。方法 采用病例對照研究。選擇解放軍總醫(yī)院近年來確診的62例軍隊AD患者為病例組,在同一醫(yī)院住院治療的離退休老干部中按照年齡段分層抽樣(按1:2比例)選取124例對照。調查方式為電話訪談。結果 單因素分析結果顯示,病例組社會活動情況明顯少于對照組,早年電磁暴露、體育鍛煉情況、負性生活事件、慢性阻塞性肺病病史、既往癌癥病史、癡呆家族史在兩組間差異有顯著性。在調整相關影響因素后,負性生活事件、癡呆家族史、社會活動量的OR值(95％CI)分別為3.27(1.53～6.97)、5.78(1.39～24.10)和0.81(0.72～0.92),早年電磁暴露的OR值(95％CI)為2.49(0.96～6.45),而既往癌癥病史和吸煙似與AD呈負相關。結論 負性生活事件、癡呆家族史、社會活動減少是AD的獨立危險因素,早年電磁暴露是其可能的危險因素;吸煙和既往癌癥病史與AD呈負相關的原因可能與該老年人群的“生存偏性”有關。
[Abstract]:Objective to investigate the risk factors of Alzheimer's disease (AD) in military elderly and to analyze the relationship between early electromagnetic exposure and AD. Methods A case-control study was conducted. 62 military AD patients diagnosed in the PLA General Hospital in recent years were selected as the case group. 124 controls were selected according to the age group (according to the proportion of 1:2) among the retired cadres hospitalized in the same hospital. The way of investigation is telephone interview. Results the results of univariate analysis showed that the social activities in the case group were significantly lower than those in the control group, early electromagnetic exposure, physical exercise, negative life events, chronic obstructive pulmonary disease history, and previous cancer history. There was significant difference in the family history of dementia between the two groups. After adjusting for the related influencing factors, the OR values (95%CI) of negative life events, family history of dementia and social activity were 3.27 (1.53 鈮，

本文編號：2492685