【摘要】： 目的觀察軍隊(duì)老年男性代謝綜合征(metabolic syndrome，MS)患者血清白細(xì)胞介素10(Interleukin-10，IL-10)、高敏C反應(yīng)蛋白(high sensitive C reactive protein，hs-CRP)水平的變化，探討炎癥標(biāo)志物IL-10、hs-CRP與代謝綜合征的關(guān)系。 方法對(duì)2006年11月至12月間在163醫(yī)院門(mén)診體檢的408名軍隊(duì)退休男性老干部測(cè)定腰圍(waist circumference，WC)、體重、身高、血壓、空腹血糖(fasting plasma glucose，F(xiàn)PG)、血脂水平，并計(jì)算體重指數(shù)(body mass Index，BMI)，分析其代謝紊亂的特征。據(jù)國(guó)際糖尿病聯(lián)盟(IDF)頒布的MS診斷標(biāo)準(zhǔn)，入選58例老年MS患者和29例年齡相匹配的對(duì)照者，測(cè)量其血壓、腰圍(WC)、體重、身高、體重指數(shù)(BMI)、血脂、空腹血糖(FPG)、空腹血胰島素(fastinginsulin，F(xiàn)INS)、抵抗指數(shù)(homeostasis model assessment of Insulin Resistance，HOMA-IR)，血清IL-10濃度用酶聯(lián)免疫吸附劑法測(cè)定(enzyme linked immunosorbent assay，，ELISA)，血清hs-CRP水平用乳膠增強(qiáng)免疫比濁法檢測(cè)。 結(jié)果1．408名軍隊(duì)退休男性老干部中超重或肥胖者237例(占58.1％)，中心性肥胖者(腰圍≥90cm)243例(占51.6％)，高血壓病者287例(占70.3％)，高血糖患者135例(占33.1％)，血脂紊亂者(高TG或／和低HDL-C)95例(占23-3％)，MS患者135例(占33.1％)；可見(jiàn)2種代謝紊亂組中以高血壓+超重或肥胖組合(占58.9％)最多，3種代謝紊亂組中以高血壓+超重或肥胖+血脂紊亂組合(占57.5％)最多；有3種以上MS相關(guān)疾病者占該人群總數(shù)的近30％。2．MS組血清IL-10濃度顯著低于對(duì)照組(P＜0.05)；按HOMA-IR分組發(fā)現(xiàn)：胰島素抵抗亞組(HOMA-IR≥4.3 1)IL-10水平顯著低于非胰島素抵抗亞組(HOMA-IR＜4.3 1)(P=0.000)。3．MS患者血清hs-CRP濃度顯著高于對(duì)照者(P＜0.05)；按HOMA-IR、WC分組發(fā)現(xiàn)：非胰島素抵抗亞組(HOMA-IR＜4.31)hs-CRP水平低于胰島素抵抗亞組(HOMA-IR≥4.31) (P＞0.05)；中心性肥胖亞組(WC≥90cm)血清hs-CRP濃度顯著高于非中心性肥胖亞組(WC＜90cm) (P=0.008)；MS患者血清hs-CRP水平隨著MS組分?jǐn)?shù)目的增加而升高。4．Pearson相關(guān)分析顯示在MS組中，IL-10與HOMA-IR(r=-0.797，P=0.000)、FINS(r=-0.731，P=0.000)、FPG(r=-0.303，P=0.021)之間存在負(fù)相關(guān)。在MS組中，hs-CRP與年齡(r=0.270，P=0.040)、BMI(r=0.346，P=0.008)之間存在正相關(guān)。5．Stepwise逐步回歸分析顯示在MS組中，腰圍、HOMA—IR、FINS可能為IL-10的影響因素；在MS組中，年齡、BMI可能為hs-CRP的影響因素； 結(jié)論1．408名軍隊(duì)退休男性老干部中MS相關(guān)疾病患者所占比例較高。2．老年男性MS患者血清IL-10濃度顯著降低血清hs-CRP顯著升高，提示存在低度慢性炎癥。3．老年男性MS，患者血清IL-10濃度降低，可能與高胰島素血癥、胰島素抵抗密切相關(guān)。4．老年男性MS患者血清hs-CRP水平隨著MS組分?jǐn)?shù)目的增加而升高，并可能與年齡、BMI相關(guān)。
[Abstract]:Objective to observe the changes of serum IL-10 (Interleukin-10,IL-10) and Gao Min C-reactive protein (high sensitive C reactive protein,hs-CRP (high sensitive C reactive protein,hs-CRP) in elderly men with metabolic syndrome (metabolic syndrome,MS), and to explore the inflammatory marker IL-10,. Relationship between hs-CRP and metabolic syndrome. Methods from November to December 2006, the waist circumference (waist circumference,WC), weight, height, blood pressure, fasting blood glucose (fasting plasma glucose,FPG) and blood lipid levels were measured in 408retired male military cadres who were examined in the outpatient clinic of 163Hospital. The body mass index (body mass Index,BMI) was calculated and the characteristics of metabolic disorder were analyzed. According to the MS diagnostic standard promulgated by the International Diabetes Union (IDF), 58 elderly MS patients and 29 age-matched controls were selected to measure their blood pressure, waist circumference (WC), weight, height, body mass index (BMI),) blood lipid. Fasting blood glucose (FPG), fasting blood insulin (fastinginsulin,FINS), resistance index (homeostasis model assessment of Insulin Resistance,HOMA-IR), serum IL-10 concentration was determined by enzyme-linked immunosorbent assay (enzyme linked immunosorbent assay,ELISA), The level of serum hs-CRP was detected by latex enhanced immune turbidimetry. Results of the 1.408 retired male cadres, 237 (58.1%) were overweight or obese, 243( 51.6%) were central obesity (waist circumference 90 cm), and 287 (70.3%) were hypertension. There were 135 patients with hyperglycemia (33.1%) and 95 patients with dyslipidemia (high TG or / and low HDL-C) (23%) with), MS (33.1%). It can be seen that hypertension overweight or obesity group (58.9%) is the most common metabolic disorder group, and hypertension overweight or obese dyslipidemia group (57.5%) is the most common metabolic disorder group. The serum IL-10 concentration in the near 30%.2.MS group, which accounted for more than three MS-related diseases, was significantly lower than that in the control group (P < 0.05). According to HOMA-IR group, the level of IL-10 in insulin resistance subgroup (HOMA-IR 鈮

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