【摘要】：目的　探討人參二醇對(duì)四氧化二氮 (N2 O4)染毒鼠血清蛋白醇抑制物水平的影響 ,尋找簡(jiǎn)便易行的N2 O4中毒防治新途徑。方法　LACA雄性小鼠 ,18～ 2 2g,共 12 3只。按體重隨機(jī)分成對(duì)照組、染毒組、染毒加人參二醇組 ,每組 4 1只。模型制作 :對(duì)照組及染毒組每只小鼠均給予腹腔注射生理鹽水 0 2mL ,人參二醇組每只小鼠給予腹腔注射人參二醇 0 2mL ,連續(xù) 7d。復(fù)制N2 O4急性中毒性肺水腫模型 ,中毒后 15min、1h分別腹腔內(nèi)注射上述藥物共 2次。注射完畢后觀察小鼠的表現(xiàn)和存活情況。 7d后取眼球靜脈血血清 ,- 2 0℃保存。測(cè)定血清α1-抗胰蛋白酶 (α1-
[Abstract]:Aim to investigate the effect of panaxadiol on the level of serum albumin alcohol inhibitor in rats exposed to N 2O 4, and to find a new way to prevent and cure N 2O 4 poisoning. Methods A total of 123 male LACA mice (18 ~ 22 g) were used in this study. They were randomly divided into control group (n = 41) and panaxadiol group (n = 41) according to body weight. Model making: each mouse in the control group and the exposure group was given intraperitoneal injection of 0 2mL of normal saline, and each mouse in the panaxadiol group was injected intraperitoneally with 0 2mL of panaxadiol for 7 days. The model of acute toxic pulmonary edema induced by N 2O 4 was established. The above drugs were injected intraperitoneally for 2 times 15 min and 1 h after poisoning respectively. After injection, the performance and survival of the mice were observed. After 7 days, the blood serum of eyeball vein was collected and stored at-20 鈩，

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