發(fā)布時間：2019-04-26 13:43

【摘要】：空間飛行與返回 1G環(huán)境后的過氧化損傷密切相關(guān) ,長期空間飛行損傷更為明顯 ,著陸后這種效應(yīng)甚至可持續(xù)幾周。在人體表現(xiàn)為紅細(xì)胞膜的脂質(zhì)過氧化程度增加、某些血液中的抗氧化物含量減少 ,8 iso prostaglandin和 8 oxo 7,8 dihydro 2 deoxyguanosine的尿排出增加。 8 iso prostaglandin和 8 oxo 7,8 dihydro 2 deoxyguanosine分別為脂質(zhì)和DNA氧化損傷的標(biāo)記物。上述改變應(yīng)歸結(jié)為飛行過程中出現(xiàn)的營養(yǎng)缺乏和恢復(fù)期急待補充營養(yǎng)的肌肉與其他組織對氨基酸的競爭等復(fù)合作用。對嚙齒動物的研究極大地補充了人體觀察結(jié)果。大多數(shù)嚙齒動物實驗表明飛行后脂質(zhì)過氧化產(chǎn)物增加 ,而抗氧化酶活性下降 ,是由于返回地球重力時的應(yīng)激反應(yīng)。在食品中添加抗氧化物可減輕內(nèi)源性氧化防御和氧化物合成之間的失衡 ,改善飛行后氧化應(yīng)激狀態(tài)。
[Abstract]:Space flight is closely related to peroxidation damage after returning to 1G environment, and long-term space flight damage is more obvious, and this effect can last for several weeks even after landing. In human body, the lipid peroxidation of erythrocyte membrane increased, the antioxidant content in some blood decreased, and the urinary excretion of 8 iso prostaglandin and 8 oxo 7, 8 dihydro 2 deoxyguanosine increased. 8 iso prostaglandin and 8 oxo 7, 8 dihydro 2 deoxyguanosine were markers of lipid and DNA oxidative damage, respectively. The above changes can be attributed to the combined effects of nutritional deficiency and recovery period on amino acid competition between muscle and other tissues which are in urgent need of supplemental nutrition during flight. The study of rodents greatly complements the results of human observations. Most rodent experiments showed that lipid peroxidation products increased and antioxidant enzyme activity decreased after flight, which was due to stress response when returning to the gravity of the earth. Adding antioxidants to food can reduce the imbalance between endogenous oxidation defense and oxide synthesis and improve post-flight oxidative stress.
【作者單位】： 航天醫(yī)學(xué)工程研究所 航天醫(yī)學(xué)工程研究所 航天醫(yī)學(xué)工程研究所 航天醫(yī)學(xué)工程研究所
【基金】：中國載人航天工程基金資助
【分類號】：R85

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