植入貧鈾片大鼠血液和肝腎功能的變化
發(fā)布時間:2018-12-07 09:22
【摘要】:目的 :弄清嵌入 (植入 )貧鈾彈片是否會引起機體血液、肝腎功能的變化 ,為救治提供依據(jù) .方法 :手術植入貧鈾片 ,臨床生化自動檢測儀測定各指標 .結果 :在植片后 5mo大鼠白細胞數(shù)顯著增高后又回降 ,淋巴細胞的變化趨勢與白細胞相同 ,紅細胞和血紅蛋白變化不大 ,血小板顯著下降后又顯著增高 .ALT和AST先升高后下降 ;T BIL一直下降 ,后雖回升 ,但仍顯著低于正常組 ;AL/AS 比值一直升高 ,后下降至 0 .3左右 .植片后初期腎功能出現(xiàn)一定損傷 ,2 0d左右逐漸好轉 ,1 2 0 1 5 0d時 ,各指標基本恢復正常 ,但尿蛋白、亞硝酸鹽異常及肌酐呈上升趨勢 .結論 :貧鈾片可引起動物血液、肝腎功能異常 ,后逐漸恢復 ,但仍殘留一些指標呈陽性
[Abstract]:Objective: to find out whether embedding depleted uranium bomb can cause changes of blood, liver and kidney function. Methods: the depleted uranium tablets were implanted in the operation and the clinical biochemical automatic detector was used to measure each index. Results: the number of white blood cells in 5mo rats increased significantly and then decreased, the change trend of lymphocytes was the same as that of white blood cells, and the changes of red blood cells and hemoglobin were not obvious. ALT and AST increased first and then decreased. T BIL decreased and then increased, but it was still significantly lower than that of the normal group, and the AL/AS ratio increased continuously, and then decreased to about 0.3. The renal function was damaged in the early stage of grafts, and gradually improved at 20 days. At 1 20150 days, the indexes returned to normal basically, but the urinary protein, nitrite abnormality and creatinine showed an increasing trend. Conclusion: depleted uranium can cause abnormal blood, liver and kidney function, and then recover gradually, but some of the remaining indexes are positive.
【作者單位】: 第三軍醫(yī)大學全軍復合傷研究所 第三軍醫(yī)大學全軍復合傷研究所 第三軍醫(yī)大學全軍復合傷研究所 第三軍醫(yī)大學全軍復合傷研究所 第三軍醫(yī)大學全軍復合傷研究所 第三軍醫(yī)大學全軍復合傷研究所 第三軍醫(yī)大學全軍復合傷研究所
【基金】:軍隊“十五”指令性課題 (0 1L0 61 )
【分類號】:R82
[Abstract]:Objective: to find out whether embedding depleted uranium bomb can cause changes of blood, liver and kidney function. Methods: the depleted uranium tablets were implanted in the operation and the clinical biochemical automatic detector was used to measure each index. Results: the number of white blood cells in 5mo rats increased significantly and then decreased, the change trend of lymphocytes was the same as that of white blood cells, and the changes of red blood cells and hemoglobin were not obvious. ALT and AST increased first and then decreased. T BIL decreased and then increased, but it was still significantly lower than that of the normal group, and the AL/AS ratio increased continuously, and then decreased to about 0.3. The renal function was damaged in the early stage of grafts, and gradually improved at 20 days. At 1 20150 days, the indexes returned to normal basically, but the urinary protein, nitrite abnormality and creatinine showed an increasing trend. Conclusion: depleted uranium can cause abnormal blood, liver and kidney function, and then recover gradually, but some of the remaining indexes are positive.
【作者單位】: 第三軍醫(yī)大學全軍復合傷研究所 第三軍醫(yī)大學全軍復合傷研究所 第三軍醫(yī)大學全軍復合傷研究所 第三軍醫(yī)大學全軍復合傷研究所 第三軍醫(yī)大學全軍復合傷研究所 第三軍醫(yī)大學全軍復合傷研究所 第三軍醫(yī)大學全軍復合傷研究所
【基金】:軍隊“十五”指令性課題 (0 1L0 61 )
【分類號】:R82
【共引文獻】
相關期刊論文 前10條
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