【摘要】：目的:通過建立高溫高濕環(huán)境下大鼠腹部創(chuàng)傷動物模型,用局部氧氣干預創(chuàng)面的方法,探討這一特殊環(huán)境下創(chuàng)面組織的病理形態(tài)學變化以及局部氧氣干預對創(chuàng)面愈合的影響,為臨床傷口護理提供理論依據(jù)。方法:將24只創(chuàng)傷大鼠隨機分為常溫對照組(NEC)、常溫氧療組(NEO)、高溫對照組(HHE)、高溫氧療組(HHO)4組,每組6只。在相應干預后的不同時間對各組動物的平均動脈壓(MAP)、創(chuàng)面愈合時間、細菌學定量、病理形態(tài)學進行觀察和檢測。結(jié)果:HHE組較NEC組創(chuàng)面腫脹程度嚴重,創(chuàng)面愈合時間長,HHO組較HHE組創(chuàng)面腫脹程度輕,創(chuàng)面愈合時間短。光鏡和電鏡觀察到HHE組創(chuàng)面肌肉纖維的病理變化均較NEC組顯著,且損傷呈進行性加重,HHO組肌肉組織損傷程度較HHE組輕。細菌學定量檢測HHE組創(chuàng)面細菌數(shù)在同一時相比NEC組高,且隨時間的延長呈顯著增長趨勢,HHO組創(chuàng)面細菌數(shù)量與HHE組比較差異有顯著性意義(P0.05)。結(jié)論:高溫高濕環(huán)境下創(chuàng)面組織病理損傷嚴重,細菌繁殖快,感染時間提前且嚴重,創(chuàng)面愈合速度慢;局部氧氣干預可抑制創(chuàng)面組織細菌繁殖,對大鼠腹部刀割創(chuàng)面有明顯的促修復作用。
[Abstract]:Objective: to investigate the pathomorphological changes of wound tissue and the effect of local oxygen intervention on wound healing by establishing an animal model of abdominal trauma in rats under high temperature and high humidity. To provide theoretical basis for clinical wound nursing. Methods: 24 traumatized rats were randomly divided into normal temperature control group (NEC), (NEO), hyperthermia control group, (HHE), hyperthermia oxygen therapy group (HHO) 4), 6 rats in each group. The wound healing time, bacteriological quantity and pathomorphology of (MAP), wound were observed and detected at different time after intervention. Results: the degree of wound swelling in HHE group was more serious than that in NEC group, and the wound healing time was longer. In HHO group, the degree of wound swelling was lighter and the healing time was shorter than that in HHE group. The pathological changes of muscle fibers in HHE group were significantly higher than those in NEC group, and the injury was progressive. The degree of muscle tissue injury in HHO group was lighter than that in HHE group. The number of bacteria in wound of HHE group was higher than that of NEC group at the same time, and the number of bacteria in HHO group was significantly higher than that in HHE group (P0.05). Conclusion: under high temperature and high humidity environment, the wound tissue has serious pathological damage, the bacteria propagate fast, the infection time is early and serious, and the wound healing speed is slow. Local oxygen intervention could inhibit the propagation of bacteria in wound tissue and could promote the repair of abdominal incision wound in rats.
【作者單位】： 解放軍第一軍醫(yī)大學南方醫(yī)院護理部 解放軍第一軍醫(yī)大學南方醫(yī)院護理部 解放軍第一軍醫(yī)大學高溫醫(yī)學研究室 解放軍第一軍醫(yī)大學高溫醫(yī)學研究室 解放軍第一軍醫(yī)大學病理教研室
【基金】：全軍醫(yī)學科研基金“十五”計劃資助(01MAI33)~~
【分類號】：R82

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