本文選題：肢體爆炸傷 + 控制性低溫�。� 參考：《第三軍醫(yī)大學(xué)學(xué)報(bào)》2007年17期

【摘要】：目的觀察早期全身和局部控制性低溫對(duì)大鼠肢體爆炸傷后繼發(fā)肺損傷的作用,探討控制性低溫在肢體爆炸傷后繼發(fā)肺損傷防治中的臨床應(yīng)用價(jià)值。方法采用大鼠肢體爆炸傷模型,動(dòng)物按隨機(jī)數(shù)字表法分為4組(每組8只):正常對(duì)照組(C)、單純致傷組(Ⅰ:致傷)、全身低溫組(Ⅱ:致傷+全身低溫6h)和局部低溫組(Ⅲ:致傷+局部低溫6h);各組分別于致傷后6h取標(biāo)本。測(cè)定肺TNF-α、IL-6、IL-10和MDA濃度;觀察肺臟病理學(xué)變化。結(jié)果大鼠致傷6h后肺TNF-α、IL-6、IL-10和MDA濃度顯著升高(P0.01);肺臟充血水腫和炎細(xì)胞浸潤(rùn)明顯;致傷大鼠經(jīng)全身低溫或局部低溫處理6h后肺、IL-6、IL-10及MDA濃度均明顯降低(P0.05);肺臟充血水腫和炎細(xì)胞浸潤(rùn)程度明顯減輕。結(jié)論早期全身或局部控制性低溫可明顯抑制肢體爆炸傷大鼠肺臟的炎性損傷和氧化損傷,減輕肺臟充血水腫和炎細(xì)胞浸潤(rùn)程度,有利于減輕爆炸傷后繼發(fā)性肺損傷。
[Abstract]:Objective to observe the effect of early systemic and local controlled hypothermia on secondary lung injury after limb explosion injury in rats, and to explore the clinical value of controlled hypothermia in the prevention and treatment of secondary lung injury after limb explosion injury. Methods the rat limb explosion injury model was used. Animals were randomly divided into 4 groups (8 rats in each group: normal control group, simple injury group (鈪，

本文編號(hào)：2032192