本文選題：應(yīng)激性體溫過(guò)高 + 梭曼�。� 參考：《中國(guó)應(yīng)用生理學(xué)雜志》2008年01期

【摘要】：目的:觀察梭曼對(duì)大鼠應(yīng)激性體溫過(guò)高的抑制作用以及中樞和外周膽堿能受體阻斷劑對(duì)其效應(yīng)的影響。方法:用無(wú)線遙測(cè)技術(shù)測(cè)量大鼠的體溫,觀察皮下注射梭曼、東莨菪堿、甲基東莨菪堿和吡啶斯的明對(duì)開放環(huán)境中大鼠應(yīng)激性體溫過(guò)高的影響。用分光光度技術(shù)測(cè)定血漿中膽堿酯酶活性。結(jié)果:①對(duì)照組大鼠在開放實(shí)驗(yàn)箱中體溫升高達(dá)0.96℃,而注射梭曼動(dòng)物體溫只升高了0.55℃。中樞性膽堿能受體阻斷劑東莨菪堿幾乎完全阻斷梭曼對(duì)應(yīng)激體溫過(guò)高的抑制作用,而外周膽堿能受體阻斷劑甲基東莨菪堿則能明顯增強(qiáng)梭曼對(duì)應(yīng)激性體溫過(guò)高的抑制作用。②外周抗膽堿酯酶劑吡啶斯的明能使血漿膽堿酯酶的活性降低至52%,同時(shí)明顯提高開放環(huán)境中大鼠應(yīng)激性體溫過(guò)高的反應(yīng)。甲基東莨菪堿幾乎可以阻斷吡啶斯的明對(duì)應(yīng)激體溫過(guò)高反應(yīng)的影響。結(jié)論:神經(jīng)毒劑梭曼可改變大鼠在開放環(huán)境中應(yīng)激性體溫過(guò)高的反應(yīng)能力,其作用主要是通過(guò)中樞毒蕈堿型膽堿能通路所致。此外,外周膽堿能神經(jīng)參與大鼠開放應(yīng)激性體溫過(guò)高的形成過(guò)程。
[Abstract]:Aim: to observe the inhibitory effect of soman on stress hyperthermia and the effect of central and peripheral cholinergic receptor blockers. Methods: the temperature of rats was measured by wireless telemetry, and the effects of subcutaneous injection of soman, scopolamine, methyl scopolamine and pyridamine on stress hyperthermia in open environment were observed. The activity of cholinesterase in plasma was determined by spectrophotometry. Results the body temperature of the rats in the control group increased to 0.96 鈩，

本文編號(hào)：1997202