本文選題：模擬失重 + 頭高位傾斜��； 參考：《航天醫(yī)學(xué)與醫(yī)學(xué)工程》2005年06期

【摘要】：目的觀察間斷性頭高位45°對(duì)21d模擬失重兔股靜脈及頸靜脈組織形態(tài)的影響。方法24只健康雄性兔,隨機(jī)分為對(duì)照組、模擬失重組和對(duì)抗組,每組8只。模擬失重組在21d實(shí)驗(yàn)期間保持頭低位-20°。對(duì)抗組在21d模擬失重期間每天保持45°頭高位傾斜2h。實(shí)驗(yàn)結(jié)束后取股靜脈和頸靜脈進(jìn)行光鏡和透射電鏡觀察。結(jié)果光鏡下可見模擬失重組股靜脈內(nèi)皮細(xì)胞脫落,平滑肌細(xì)胞層萎縮,管壁變薄;頸靜脈內(nèi)皮細(xì)胞增生,彈力層增厚;對(duì)抗組靜脈的組織形態(tài)學(xué)改變與對(duì)照組比較變化不明顯。透射電鏡下可見模擬失重組股靜脈平滑肌細(xì)胞線粒體腫脹,染色質(zhì)邊集;頸靜脈平滑肌細(xì)胞內(nèi)質(zhì)網(wǎng)發(fā)達(dá),向分泌型轉(zhuǎn)變;對(duì)抗組靜脈的超微結(jié)構(gòu)與對(duì)照組比較變化不明顯。結(jié)論21d模擬失重可引起兔股靜脈發(fā)生萎縮性改變,頸靜脈發(fā)生增生性改變;每天2h頭高位45°可部分對(duì)抗模擬失重所引起的股靜脈及頸靜脈結(jié)構(gòu)的改變。
[Abstract]:Objective to observe the effect of 45 擄intermittent head on the histological morphology of femoral vein and jugular vein in 21 d simulated weightlessness rabbits. Methods Twenty-four healthy male rabbits were randomly divided into control group (n = 8) and control group (n = 8). The anamorphic recombination remained headlow to 20 擄during 21 d experiment. During 21 days simulated weightlessness, the counteraction group maintained a high tilt of 45 擄head for 2 h. The femoral vein and jugular vein were taken and observed by light microscope and transmission electron microscope. Results under the light microscope, the endothelial cells of the femoral vein were shedding, the smooth muscle cell layer was atrophy, the wall of the vessel was thinning, the endothelial cell of the jugular vein was proliferating and the elastic layer was thickened, and the histomorphologic changes of the vein in the antagonism group were not obvious compared with the control group. Transmission electron microscopy showed that mitochondria swelling and chromatin edge aggregation of simulated lost recombined femoral vein smooth muscle cells; the endoplasmic reticulum of jugular vein smooth muscle cells developed and transformed to secretory type; the ultrastructure of vein in the antagonism group was not obviously changed compared with the control group. Conclusion simulated weightlessness for 21 days can cause atrophic changes of femoral vein and proliferative change of jugular vein in rabbits, and 45 擄high head per day can partly counteract the structural changes of femoral vein and jugular vein caused by simulated weightlessness.
【作者單位】： 第四軍醫(yī)大學(xué)航空航天醫(yī)學(xué)系 第四軍醫(yī)大學(xué)航空航天醫(yī)學(xué)系 第四軍醫(yī)大學(xué)航空航天醫(yī)學(xué)系 第四軍醫(yī)大學(xué)航空航天醫(yī)學(xué)系 第四軍醫(yī)大學(xué)航空航天醫(yī)學(xué)系 第四軍醫(yī)大學(xué)航空航天醫(yī)學(xué)系 第四軍醫(yī)大學(xué)航空航天醫(yī)學(xué)系
【基金】：國(guó)家自然科學(xué)基金資助(30000197)
【分類號(hào)】：R85

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