本文選題：暈動病 + 生姜　； 參考：《解放軍醫(yī)學雜志》2006年05期

【摘要】：目的觀察在海上口服防暈船口服液對暈船高敏者心率變異性的影響。方法在登陸艇上進行雙盲對照試驗,隨機選取10名暈船不敏感者作為對照組,40名暈船高敏者分為安慰組和試驗組,分別于開船前半小時服用安慰劑(對照組、安慰組)和防暈船口服液(試驗組),記錄受試者4h動態(tài)心電圖,應用心率變異時域、頻域分析方法評價自主神經(jīng)功能狀態(tài),并記錄受試者出現(xiàn)的暈船癥狀。結(jié)果防暈船口服液具有良好的預防暈船作用,安慰組抗暈船作用很小,有效率僅20%,而試驗組中有7例顯效,總有效率達85%,明顯優(yōu)于安慰組(P0.01)。安慰組和試驗組的時域指標全部竇性心搏R-R間期的標準差(SDNN)、相鄰R-R間期差值的均方根值(rMSSD)、相鄰RR間期大于50ms占總心動周期數(shù)的百分比(PNN50)、每5min時段平均R-R間期的標準差(SDANN)、每5min時段R-R間期標準差的平均值(SDNNindex)和頻域指標總功率(TP)、高頻功率(HF)均顯著高于對照組,其中上述指標在試驗組均顯著低于安慰組;而極低頻功率(VLF)在三組間差異無顯著性。結(jié)論防暈船口服液具有明顯的預防暈船作用,其抗運動病機制可能與降低過高的迷走神經(jīng)興奮性有關(guān)。
[Abstract]:Objective to observe the effect of oral antiseasickness oral liquid on heart rate variability in patients with seasickness Gao Min.Methods A double-blind controlled trial was conducted on board the landing boat. Ten seasickness insensitive persons were randomly selected as the control group. 40 patients with seasickness were divided into comfort group and test group. They were treated with placebo half an hour before sailing (control group).Comfort group) and anti-seasickness oral liquid (test group, recorded 4 h dynamic electrocardiogram, heart rate variability time domain, frequency domain analysis method to evaluate the autonomic nervous function, and recorded the symptoms of seasickness.Results the anti-seasickness oral liquid had a good effect on preventing seasickness. In the comfort group, the anti-seasickness effect was very small, and the effective rate was only 20. In the test group, there were 7 cases with remarkable effect, the total effective rate was 85%, which was obviously better than that of the comfort group (P 0.01).In comfort group and trial group, the standard deviation of R-R interval of sinus beats was determined by SDNN, the root mean square value of RR-R interval of adjacent R-R interval was more than that of 50ms, and the mean R-R interval per 5min period was higher than that of PNN50, and the standard deviation of R-R interval per 5min period was higher than that of PNN50.The average value of R-R interval standard deviation per 5min period and the total power in frequency domain were significantly higher than those in the control group, and the mean value of R-R interval standard deviation per 5min period was significantly higher than that of the control group, and the total power and high frequency power in the frequency domain were significantly higher than those in the control group.The above indexes were significantly lower in the trial group than in the comfort group, but the VLFs of the very low frequency power were not significantly different among the three groups.Conclusion Anti-seasickness oral liquid has obvious effect on preventing seasickness, and its mechanism of anti-motion sickness may be related to the reduction of excitability of vagus nerve.
【作者單位】：
【分類號】：R83

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