本文選題：微泵　切入點：直流電機驅(qū)動　出處：《航天醫(yī)學與醫(yī)學工程》2017年05期

【摘要】：目的為了搭建適用于我國航天醫(yī)學細胞生物學研究的小型化、集成化、自動化細胞培養(yǎng)系統(tǒng),提出了一種性能可靠、操作維護簡單、成本低廉且自帶閥控功能的泵頭分體式直流電機驅(qū)動型蠕動微泵。方法測試了基于不同額定電壓直流電機和減速比構建的微泵工作性能;并以該微泵為核心部件建立了自動細胞培養(yǎng)回路,開展了空間實驗常用細胞系MG63和血管內(nèi)皮細胞的中長周期培養(yǎng)試驗。結(jié)果零背壓下微泵流量與驅(qū)動電壓呈良好的線性關系,以額定電壓8 V(16 V)電機構建的微泵,電壓由6 V增至10 V(8 V增至12 V)時,流量由0.29 m L/min增至0.67 m L/min(2.63 m L/min增至4.95 m L/min);持續(xù)15 d的測量表明微泵工作穩(wěn)定性很好。MG63和血管內(nèi)皮細胞均可在以該微泵為核心的自動細胞培養(yǎng)回路中正常生長達15 d。結(jié)論該泵頭分體式直流電機驅(qū)動微泵工作污染風險低,流量易調(diào),可滿足我國空間自動化細胞培養(yǎng)系統(tǒng)搭建的需求。
[Abstract]:Objective to establish a miniaturized, integrated and automated cell culture system suitable for the study of cell biology in aerospace medicine in China. The low cost and self-control function of the pump head driven by the split DC motor peristaltic micro-pump. Methods the performance of the micro-pump based on different rated voltage DC motor and deceleration ratio was tested. With the micropump as the core component, the automatic cell culture loop was established, and the medium and long period culture experiments of the usual cell line MG63 and vascular endothelial cells were carried out. Results there was a good linear relationship between the flow rate and the driving voltage of the micropump under zero back pressure. A micropump constructed from a rated voltage of 8 V to 16 V) when the voltage is increased from 6 V to 10 V / 8 V to 12 V), The flow rate increased from 0.29 m L/min to 0.67 m L/min(2.63 m L/min to 4.95 mL / min, and the measurements for 15 days showed that the stability of the micropump was very good. MG63 and vascular endothelial cells could grow up to 15% in the automatic cell culture loop with the micropump as the core. Conclusion the working pollution risk of the micro-pump driven by the split DC motor of the pump head is low. The flow rate is easy to be adjusted, which can meet the need of building the space automation cell culture system in China.
【作者單位】： 中國航天員科研訓練中心航天醫(yī)學基礎與應用國家重點實驗室;
【基金】：航天醫(yī)學基礎與應用國家重點實驗室資助項目(SMFA13A03,SMFA15A02)
【分類號】：R85
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本文編號：1673956