本文選題：失重模擬　切入點(diǎn)：肺動(dòng)脈　出處：《解放軍醫(yī)學(xué)雜志》2010年11期 　論文類型：期刊論文

【摘要】：目的觀察尾部懸吊對(duì)大鼠肺內(nèi)動(dòng)脈口徑、壁厚和壁厚/內(nèi)徑比值的影響,以及X方劑對(duì)這些變化的作用效果。方法采用-30°尾部懸吊建立模擬失重大鼠模型。健康雄性Wistar大鼠18只,隨機(jī)分為對(duì)照(CON)組、7d尾部懸吊(TS7)組和尾部懸吊7d同時(shí)加用X方劑的中藥湯劑(TS7+X-dose)組,每組6只,實(shí)驗(yàn)第7天時(shí)處死各組大鼠,觀察大鼠肺動(dòng)脈的病理改變。采用Q50IW型圖像分析儀檢測每張切片中所有肺內(nèi)血管的口徑(內(nèi)、外徑)和壁厚,計(jì)算壁厚/內(nèi)徑比。結(jié)果 7d尾部懸吊主要影響50μm以下肺動(dòng)脈的內(nèi)、外徑,壁厚和壁厚/內(nèi)徑比值,此類血管是毛細(xì)血管前阻力血管,X方劑能較好緩解此類變化。結(jié)論 X方劑可能在緩解模擬失重導(dǎo)致的肺內(nèi)動(dòng)脈變化方面有較好的應(yīng)用前景。
[Abstract]:Objective To observe the effects of tail suspension on diameter of pulmonary artery in rats, wall thickness and wall thickness / diameter ratio effect, and the effect of X prescription on these changes. The establishment of -30 tail suspension rat model by simulated weightlessness method. 18 healthy male Wistar rats were randomly divided into control group (CON), 7d tail suspension (TS7) group and 7d tail suspension combined with traditional Chinese medicine decoction prescription X (TS7+X-dose) group, 6 rats in each group, the experimental rats were killed at seventh days, to observe the pathological changes of pulmonary artery in rats with pulmonary vascular. All in each section were measured Q50IW image analyzer in diameter (in diameter) and the wall thickness calculation of wall thickness / diameter than the 7d tail suspension. Results the main influence is less than 50 m in the pulmonary artery, diameter, wall thickness and wall thickness / diameter ratio, such vessels are precapillary resistance vessels, X prescription can alleviate these changes. Conclusion X may alleviate in prescription It has a good application prospect in simulating the changes of the internal pulmonary artery caused by weightlessness.

【作者單位】： 中國航天員科研訓(xùn)練中心航天醫(yī)學(xué)基礎(chǔ)與應(yīng)用國家重點(diǎn)實(shí)驗(yàn)室;解放軍總醫(yī)院南樓呼吸科;
【基金】：軍隊(duì)醫(yī)藥衛(wèi)生“十一五”計(jì)劃專項(xiàng)滾動(dòng)課題(06Z048) 武器裝備預(yù)研基金(9140A1704009JB1002) 民用航天科研預(yù)先研究項(xiàng)目(科工技[2007]302) 國家高技術(shù)研究發(fā)展計(jì)劃(2008AA12A220)
【分類號(hào)】：R852.22

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相關(guān)期刊論文 前3條

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本文編號(hào)：1602578