CTA評(píng)價(jià)冠狀動(dòng)脈管壁可擴(kuò)張度與冠心病主要危險(xiǎn)因素的關(guān)系
發(fā)布時(shí)間：2019-05-12 12:37
【摘要】：目的 探討冠狀動(dòng)脈管壁可擴(kuò)張度與冠心病主要危險(xiǎn)因素的關(guān)系。 材料和方法 入組118例受試者，包括43例健康老年人（其中男性14名，平均年齡56±4歲），25例高血壓患者（其中男性12名，平均年齡60±6歲），31例高脂血癥患者（其中男性18名，平均年齡60±6歲），19例糖尿病患者（其中男性9名，平均年齡59±6歲），對(duì)全部受試者測(cè)量血壓并進(jìn)行冠狀動(dòng)脈CTA掃描，分別測(cè)量收縮末期和舒張中期左前降支近端距左主干開口以遠(yuǎn)7mm處管腔橫截面積，可擴(kuò)張度（CDI）=［（收縮末期管腔面積－舒張中期管腔面積）／〔脈壓差×舒張末期管腔面積〕］×1000，，脈壓差計(jì)為肱動(dòng)脈收縮壓與舒張壓的差，比較各組病人冠狀動(dòng)脈管壁可擴(kuò)張度的差異。 結(jié)果 高血壓、高脂血癥、糖尿病病人冠狀動(dòng)脈可擴(kuò)張度均比對(duì)照組健康人群減小。健康人冠狀動(dòng)脈可擴(kuò)張度為5.24±1.40mmHg~(-1)×10~3，高血壓、高脂血癥、糖尿病患者冠狀動(dòng)脈可擴(kuò)張度分別3.66±1.39mmHg~(-1)×10~3，3.72±1.39mmHg~(-1)×10~3，3.30±0.84mmHg~(-1)×10~3，高血壓、高脂血癥、糖尿病病人與健康人的冠狀動(dòng)脈擴(kuò)張度有差異，P0.001。 結(jié)論 1.高血壓、高脂血癥、糖尿病的病人與健康人的冠狀動(dòng)脈管壁可擴(kuò)張度均有顯著差異。 2.高血壓組、高脂血癥組、糖尿病組病人之間冠狀動(dòng)脈可擴(kuò)張度沒有顯著差異。高血壓、高脂血癥、糖尿病病人冠狀動(dòng)脈的可擴(kuò)張度比正健康人群明顯減低，冠狀動(dòng)脈可擴(kuò)張度（CDI）明顯受冠心病已知的主要危險(xiǎn)因素的影響，CDI能可靠評(píng)估血管功能障礙的減低程度。
[Abstract]:Objective to investigate the relationship between dilatability of coronary artery wall and main risk factors of coronary heart disease (CHD). Materials and methods 118 subjects, including 43 healthy elderly (14 males, mean age 56 鹵4 years) and 25 hypertensive patients (12 males, mean age 60 鹵6 years), were enrolled in the study. Thirty-one patients with hyperlipidemia (18 males, mean age 60 鹵6 years) and 19 patients with diabetes mellitus (9 males, mean age 59 鹵6 years) were enrolled in this study. Blood pressure was measured and coronary artery CTA scan was performed in all subjects. The cross section area of the lumen near the proximal end of the left anterior descending branch from the left trunk opening to the far 7mm was measured at the end of contraction and the middle diastolic period, respectively. Dilatability (CDI) = [(end-systolic lumen area-mid-diastolic lumen area) / (pulse pressure difference 脳 end-diastolic lumen area) 脳 1000, pulse pressure difference is the difference between brachial artery systolic and diastolic pressure, The distensibility of coronary artery wall in each group was compared. Results the coronary artery distensibility in patients with hypertension, hyperlipidemia and diabetes mellitus was lower than that in the control group. The dilatation degree of coronary artery in healthy subjects was 5.24 鹵1.40 mmHg~ (- 1) 脳 10 鈮
本文編號(hào)：2475398
[Abstract]:Objective to investigate the relationship between dilatability of coronary artery wall and main risk factors of coronary heart disease (CHD). Materials and methods 118 subjects, including 43 healthy elderly (14 males, mean age 56 鹵4 years) and 25 hypertensive patients (12 males, mean age 60 鹵6 years), were enrolled in the study. Thirty-one patients with hyperlipidemia (18 males, mean age 60 鹵6 years) and 19 patients with diabetes mellitus (9 males, mean age 59 鹵6 years) were enrolled in this study. Blood pressure was measured and coronary artery CTA scan was performed in all subjects. The cross section area of the lumen near the proximal end of the left anterior descending branch from the left trunk opening to the far 7mm was measured at the end of contraction and the middle diastolic period, respectively. Dilatability (CDI) = [(end-systolic lumen area-mid-diastolic lumen area) / (pulse pressure difference 脳 end-diastolic lumen area) 脳 1000, pulse pressure difference is the difference between brachial artery systolic and diastolic pressure, The distensibility of coronary artery wall in each group was compared. Results the coronary artery distensibility in patients with hypertension, hyperlipidemia and diabetes mellitus was lower than that in the control group. The dilatation degree of coronary artery in healthy subjects was 5.24 鹵1.40 mmHg~ (- 1) 脳 10 鈮
本文編號(hào)：2475398
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