發(fā)布時間：2019-01-24 20:13

【摘要】：目的 分析OsiriX用來測量感染性角膜炎在眼前段光學(xué)相干斷層成像(AS-OCT, anterior segment optical coherence tomography)的可行性,測量指標包括浸潤部位角膜厚度,浸潤面積以及與浸潤部位密度變化相關(guān)的值。 資料與方法 回顧性分析2011年12月至2012年3月在我院診斷為感染性角膜炎的病人的32張AS-OCT圖片。首先比較Visante OCT機器自帶軟件所測量的浸潤部位中心角膜厚度與OsiriX測量所得的浸潤部位中心角膜厚度是否具有一致性。再分析OsiriX測量感染性角膜炎AS-OCT圖片上的浸潤面積與OCT值的可行性,評估指標包括測量的可重復(fù)性和可再現(xiàn)性。Visante OCT與OsiriX兩種測量方法的一致性采用配對T檢查,Pearson線性相關(guān)分析,Bland-Altman分析法綜合分析。OsiriX測量感染性角膜炎AS-OCT圖片的可行性采用配對T檢查和組內(nèi)相關(guān)系數(shù)(intraclass correlation coefficients, ICC)綜合分析。以P0.05作為差異有統(tǒng)計學(xué)差異。 結(jié)果 1、Visante OCT與OsiriX測量所測量的浸潤部位中心角膜厚度,平均值分別為700.19±171.67μm和694±166.84μm,差值的平均值為6.21±10.45μm,差異具有統(tǒng)計學(xué)意義(P0.05)。Pearson線性相關(guān)分析示兩種方法測量所得的浸潤部位中心角膜厚度具有高度的相關(guān)性(相關(guān)系數(shù)r為0.998,P0.05)。由Bland—Altman分析法示僅3.1%(1/32)在95%一致性區(qū)間之外,兩者的一致性較好。 2、OsiriX測量感染性角膜炎浸潤病灶面積,同一操作者兩次測量的結(jié)果平均值分別是2207641.94±1196023.88μm2和2170665.94±1170061.01“m2,兩者結(jié)果無顯著性差異(P值0.05),具有良好的可重復(fù)性(ICC0.9)。兩個不同操作者測量結(jié)果的平均值分別是2207641.94±1196023.88μm2和2201682.04±1177914.01μm2,P值為0.780.05,結(jié)果無顯著性差異(P值0.05),具有良好的可再現(xiàn)性(ICC0.9)。 3、OsiriX測量感染性角膜炎浸潤病灶OCT值,同一操作者兩次測量的結(jié)果平均值分別是368.38±135.22和376.72±133.54,結(jié)果無顯著性差異(P值0.05),具有良好的可重復(fù)性(ICC0.9)。兩個不同操作者兩次測量的結(jié)果平均值分別是368.38±135.22和371.63±130.06,結(jié)果無顯著性差異(P值0.05),具有良好的可再現(xiàn)性(ICC0.9)。 結(jié)論 OsiriX測量感染性角膜炎浸潤病灶中心部位角膜厚度與Visante OCT機器自帶的軟件具有良好的一致性,其測量不規(guī)則病灶的面積的功能以及和病灶密度相關(guān)的OCT值的功能具有較好的可重復(fù)性和可再現(xiàn)性,因此認為OsiriX能夠用于測量感染性角膜炎AS-OCT的圖片。
[Abstract]:Objective to analyze the feasibility of using OsiriX to measure the corneal thickness of infective keratitis in anterior segment optical coherence tomography (AS-OCT, anterior segment optical coherence tomography). The infiltration area and the value related to the change of the density of the infiltrating site. Materials and methods 32 AS-OCT images of patients with infectious keratitis from December 2011 to March 2012 were analyzed retrospectively. The thickness of the central cornea of the infiltrating site measured by Visante OCT software was compared with that of the central corneal thickness of the infiltrating site measured by OsiriX. The feasibility of OsiriX in measuring the area of infiltration and the value of OCT on AS-OCT images of infectious keratitis was analyzed. The evaluation indexes included reproducibility and reproducibility of. Visante OCT and OsiriX. Pearson linear correlation analysis and Bland-Altman analysis were used to analyze the feasibility of OsiriX in the measurement of AS-OCT images of infectious keratitis by paired T test and (intraclass correlation coefficients, ICC) comprehensive analysis of intragroup correlation coefficient. With P0.05 as the difference was statistically significant. Results 1Visante OCT and OsiriX were used to measure the central corneal thickness of the infiltrating site. The mean values were 700.19 鹵171.67 渭 m and 694 鹵166.84 渭 m, respectively, and the difference was 6.21 鹵10.45 渭 m. The difference was statistically significant (P0.05). Pearson linear correlation analysis showed that there was a high correlation between the central corneal thickness measured by the two methods (r = 0.998 P 0.05). Bland-Altman analysis shows that only 3.1% (1 / 32) is outside the 95% consistency range. 2OsiriX was used to measure the area of infectious keratitis. The mean values of the two measurements were 2207641.94 鹵1196023.88 渭 m ~ 2 and 2170665.94 鹵1170061.01 "m ~ 2, respectively. There was no significant difference between the two results (P < 0.05). It has good repeatability (ICC0.9). The average values of two different operators were 2207641.94 鹵1196023.88 渭 m ~ 2 and 2201682.04 鹵1177914.01 渭 m ~ 2, P = 0.780.05.The results showed no significant difference (P < 0.05) and had good reproducibility (ICC0.9). 3OsiriX was used to measure the OCT value of infectious keratitis infiltrating foci. The mean values of the two measurements of the same operator were 368.38 鹵135.22 and 376.72 鹵133.54, respectively. There was no significant difference in the results between the two groups (P < 0. 05). It has good repeatability (ICC0.9). The mean values of the two measurements were 368.38 鹵135.22 and 371.63 鹵130.06, respectively. There was no significant difference in the results (P 0. 05), and there was good reproducibility (ICC0.9). Conclusion the measurement of corneal thickness at the center of infectious keratitis by OsiriX is in good agreement with the software of Visante OCT machine. The function of measuring the area of irregular lesions and the OCT value related to the density of the lesion is reproducible and reproducible. It is considered that OsiriX can be used to measure the AS-OCT images of infectious keratitis.
【學(xué)位授予單位】：浙江大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2012
【分類號】：R772.21;R816.97

【共引文獻】

相關(guān)期刊論文 前8條

1 杜建軍;郝瑋琳;劉有軍;喬愛科;;醫(yī)學(xué)圖像三維可視化系統(tǒng)框架設(shè)計與開發(fā)[J];北京生物醫(yī)學(xué)工程;2008年06期

2 夏湘平;孫曉川;何朝暉;張曉冬;;CT血管成像在動脈瘤夾閉術(shù)后隨訪中的應(yīng)用及進展[J];中國腦血管病雜志;2012年02期

3 劉曉兵;孫明華;陸民;黃新天;陸信武;黃英;李維敏;趙海光;殷敏毅;施慧華;蔣米爾;;多層螺旋CT圖像后處理軟件OsiriX顯示Adamkiewicz動脈及其在主動脈疾病腔內(nèi)治療中的應(yīng)用研究[J];外科理論與實踐;2009年03期

4 李章一;陳剛;;動態(tài)三維CT處理軟件OsiriX在頜面部骨折個性化重建中的應(yīng)用[J];中國組織工程研究與臨床康復(fù);2011年48期

5 劉泗巖;盧光明;周長圣;張龍江;;開源影像診斷軟件的現(xiàn)狀與一種集成開發(fā)平臺[J];醫(yī)療衛(wèi)生裝備;2011年11期

6 曹洪海;張立海;張巍;趙燕鵬;郝明;張偉;屈波;唐佩福;;Osirix圖像處理軟件在老年髖部骨折快速診斷與手術(shù)決策中的應(yīng)用初探[J];中國矯形外科雜志;2012年08期

7 馬聰;張禮榮;尉傳社;王冬青;王德航;;3.0TMR半自動軟件軟骨體積定量測量的可重復(fù)性及準確性[J];中國醫(yī)學(xué)影像技術(shù);2010年04期

8 王雙燕;;闌尾炎患者手術(shù)的外科護理[J];中國農(nóng)村衛(wèi)生事業(yè)管理;2013年04期

相關(guān)碩士學(xué)位論文 前5條

1 趙嘉華;三維重建技術(shù)在胸外科臨床中的應(yīng)用[D];中國人民解放軍軍醫(yī)進修學(xué)院;2011年

2 胡建;基于COM+和ASP技術(shù)訪問DICOM持久性對象的研究[D];四川大學(xué);2006年

3 于靜瑩;面向醫(yī)學(xué)圖像轉(zhuǎn)換的中間件設(shè)計[D];東北師范大學(xué);2008年

4 肖強菊;初級PET/CT交互系統(tǒng)設(shè)計[D];北京郵電大學(xué);2008年

5 馬聰;3.0T MRI上膝關(guān)節(jié)軟骨體積的定量測量研究[D];江蘇大學(xué);2010年

，

本文編號：2414810