發(fā)布時(shí)間：2018-12-24 12:05

【摘要】：研究目的:本研究將采用不同恢復(fù)性干預(yù)手段對(duì)延遲性肌肉酸痛進(jìn)行治療干預(yù),并對(duì)比治療效果差異,旨在研究肌內(nèi)效貼對(duì)延遲性肌肉酸痛的疼痛緩解效果,并嘗試探討其機(jī)制。研究方法:招募40名健康在校大學(xué)男生,將受試者隨機(jī)分為5組,分別是肌內(nèi)效貼治療組、肌內(nèi)效貼預(yù)防組、熱療組、安慰劑組和空白對(duì)照組。所有受試者均接受運(yùn)動(dòng)造模,產(chǎn)生延遲性肌肉酸痛(肌肉急性運(yùn)動(dòng)損傷),并在隨后的96h內(nèi)接受不同干預(yù)手段進(jìn)行恢復(fù)治療,分別為使用肌內(nèi)效貼治療、使用肌內(nèi)效貼預(yù)防并治療、使用熱療的方式治療、使用無(wú)彈性普通貼布干預(yù)和不使用任何干預(yù)方式。通過(guò)觀察受試者的血液指標(biāo)(白細(xì)胞介素-6、肌酸激酶)和主觀疼痛感受(Mc Gill量表、GPRS評(píng)分)的恢復(fù)變化情況,來(lái)評(píng)價(jià)肌內(nèi)效貼的治療效果并探討潛在作用機(jī)制。研究結(jié)果:白細(xì)胞介素-6(IL-6)和肌酸激酶(CK)通過(guò)繪制恢復(fù)時(shí)間的ROC曲線并計(jì)算AUC后分析發(fā)現(xiàn),肌內(nèi)效貼治療組和肌內(nèi)效貼預(yù)防組IL-6恢復(fù)時(shí)間的AUC分別為0.727和0.695,優(yōu)于熱療組的0.617和安慰劑對(duì)照組的0.641。肌內(nèi)效貼治療組CK恢復(fù)時(shí)間的AUC為0.672,優(yōu)于其他三種干預(yù)組。主觀疼痛感受分析采用RM ANOVA,肌內(nèi)效貼預(yù)防組與空白對(duì)照組之間Mc Gill評(píng)分有統(tǒng)計(jì)學(xué)差異(p0.05);安慰劑對(duì)照組與空白對(duì)照組之間Mc Gill評(píng)分有統(tǒng)計(jì)學(xué)差異(p0.05)。對(duì)GPRS評(píng)分的分析發(fā)現(xiàn),肌內(nèi)效貼預(yù)防組與空白對(duì)照組之間有統(tǒng)計(jì)學(xué)差異(p0.05);熱療組與空白對(duì)照組之間有統(tǒng)計(jì)學(xué)差異(p0.05);安慰劑對(duì)照組與空白對(duì)照組之間有統(tǒng)計(jì)學(xué)差異(p0.05)。研究結(jié)論:使用肌內(nèi)效貼能夠促進(jìn)運(yùn)動(dòng)損傷急性期的炎癥反應(yīng)恢復(fù),并縮短損傷恢復(fù)時(shí)間;運(yùn)動(dòng)過(guò)程中使用肌內(nèi)效貼能夠減輕運(yùn)動(dòng)損傷后的炎癥反應(yīng)程度,因此具有較好的運(yùn)動(dòng)損傷預(yù)防效果。使用肌內(nèi)效貼對(duì)運(yùn)動(dòng)損傷進(jìn)行預(yù)防并治療,能夠顯著緩解一次性大強(qiáng)度運(yùn)動(dòng)后的疼痛。其對(duì)于疼痛的緩解作用可能跟加速炎癥反應(yīng)恢復(fù),抑制炎癥反應(yīng)細(xì)胞因子IL-6的釋放有關(guān)。
[Abstract]:Objective: in this study, different restorative interventions were used to treat delayed muscle soreness, and the therapeutic effects were compared in order to study the analgesic effect of intramuscular paste on delayed muscle soreness. And try to explore its mechanism. Methods: forty healthy male students were recruited and randomly divided into 5 groups: intramuscular paste group, intramuscular patch prevention group, hyperthermia group, placebo group and blank control group. All the subjects were treated with motor modeling and delayed muscle soreness (acute muscle movement injury), and were treated with different intervention methods in the following 96 hours, which were treated with intramuscular patch. Use intramuscular plaster to prevent and treat, use hyperthermia therapy, use inelastic general patch intervention and no intervention. In order to evaluate the therapeutic effect and explore the potential mechanism of intramuscular patch, the changes of blood indexes (interleukin-6, creatine kinase) and subjective pain perception (Mc Gill scale (Mc Gill scale, GPRS score) were observed. Results: interleukin-6 (IL-6) and creatine kinase (CK) were analyzed by drawing ROC curve of recovery time and calculating AUC. The AUC of IL-6 recovery time in the intramuscular paste group and the intramuscular paste preventive group were 0.727 and 0.695, respectively, which were better than 0.617 in the hyperthermia group and 0.641 in the placebo group. The AUC of CK recovery time in the intramuscular paste group was 0.672, which was better than that in the other three intervention groups. Subjective pain perception analysis using RM ANOVA, intramuscular paste between the prevention group and the blank control group between the Mc Gill score was significantly different (p0.05), placebo control group and blank control group between the Mc Gill score was significantly different (p0.05). The analysis of GPRS score showed that there was significant difference between the prevention group and the blank control group (p0.05), the difference between the hyperthermia group and the blank control group was significant (p0.05), and the difference was significant between the hyperthermia group and the blank control group (p0.05). There was significant difference between placebo group and blank control group (p0.05). Conclusion: the application of intramuscular plaster can promote the recovery of inflammatory response and shorten the recovery time of injury in the acute stage of sports injury. The use of intramuscular paste during exercise can reduce the degree of inflammatory response after exercise injury, so it has a better preventive effect of exercise injury. The use of intramuscular paste to prevent and treat sports injuries can significantly relieve the pain after one-off high-intensity exercise. Its analgesic effect may be related to accelerating the recovery of inflammatory response and inhibiting the release of inflammatory cytokine IL-6.
【學(xué)位授予單位】：上海體育學(xué)院
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類(lèi)號(hào)】：R87

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