【摘要】：目的調(diào)查軍隊(duì)人群乙肝血清抗體的本底水平,觀察重組乙肝疫苗(20μg/ml)的免疫效果,為探索適合新兵、新學(xué)員的乙肝免疫程序打下基礎(chǔ)。方法通過(guò)血清抗體初篩確定10 102名新兵為觀察對(duì)象,免疫前抗-HBs檢測(cè)結(jié)果為弱陽(yáng)性者按照0、1程序接種2針乙肝疫苗,分別在2針后測(cè)抗-HBs水平;免疫前抗-HBs檢測(cè)結(jié)果為陰性者按照0、1、6程序接種3針乙肝疫苗,分別在第2、3針后測(cè)抗-HBs水平;比較不同針次后的抗-HBs陽(yáng)轉(zhuǎn)率、抗體幾何平均滴度(GMT)水平,陰性者的高應(yīng)答反應(yīng)。結(jié)果免疫前10 102名觀察對(duì)象的血清抗-HBs檢測(cè)中弱陽(yáng)性者為1090人(10.8%),陰性者為3251人(32.2%)。弱陽(yáng)性者接種乙肝疫苗1、2針后陽(yáng)轉(zhuǎn)率分別為90.0%、97.8%,GMT分別為5007.75 m IU/ml和6295.77 m IU/ml;接種2針陽(yáng)轉(zhuǎn)率明顯優(yōu)于接種1針(P0.01)。陰性者接種乙肝疫苗2、3針后采血,陽(yáng)轉(zhuǎn)率分別為86.1%、98.7%,高應(yīng)答反應(yīng)率分別為56.4%、87.5%,GMT分別為1214.41 m IU/ml和2231.57 m IU/ml;接種3針陽(yáng)轉(zhuǎn)率明顯優(yōu)于接種2針(P0.01)。本次試驗(yàn)期間,未收到三級(jí)(含)及以上不良反應(yīng)報(bào)告。結(jié)論有必要在免疫前先進(jìn)行抗-HBs檢測(cè),再選用重組乙肝疫苗(20μg/ml)進(jìn)行科學(xué)接種;血清抗-HBs弱陽(yáng)性對(duì)象選用0、1兩針接種程序,血清抗-HBs陰性對(duì)象選用0、1、6三針接種程序,均可獲得明顯的免疫效果。
[Abstract]:Objective to investigate the background level of hepatitis B antibody in army population, and to observe the immune effect of recombinant hepatitis B vaccine (20 渭 g/ml) so as to lay a foundation for exploring the hepatitis B immunization program suitable for recruits and new cadets. Methods 10 102 recruits were screened by serum antibody. The results of anti-HBs test before immunization showed that the weakly positive persons were inoculated with 2 doses of hepatitis B vaccine according to the program of 0: 1, and the level of anti-HBs was measured after 2 doses. Three doses of hepatitis B vaccine were inoculated according to the procedure of 01 / 6, and the level of anti-HBs was measured after the second dose of 3 doses in the patients who were negative for anti-HBs test before and after immunization. The positive conversion rate of anti-HBs, the (GMT) level of geometric mean titer of antibody and the high response of negative patients were compared. Results 1090 (10.8%) cases were weakly positive and 3251 (32.2%) were negative in the detection of serum anti- HBs in 10 102 subjects before immunization. The positive conversion rates of the weakly positive patients inoculated with hepatitis B vaccine were 90.097.8 and 5007.75 m IU/ml and 6295.77 m IU/ml;, respectively, which were significantly better than that of the first dose (P0.01). The positive conversion rates were 86.1 and 98.7, respectively, and the high response rates were 56.4 and 87.5 IU/ml, respectively, and 2231.57 IU/ml; and 1214.41 m IU/ml, respectively, in the patients with negative hepatitis B vaccine. The positive conversion rate of 3 needles inoculated was significantly better than that of 2 needles inoculated (P0.01). During this trial, no adverse reactions were reported at level 3 (inclusive) or above. Conclusion it is necessary to detect anti-HBs before immunization and then select recombinant hepatitis B vaccine (20 渭 g/ml) for scientific inoculation. Two inoculation procedures were used for the weakly positive subjects with serum anti-HBs and three injections for the negative subjects with anti-HBs. The results showed that the immune effect was obvious.
【作者單位】： 中央軍委后勤保障部衛(wèi)生局;解放軍疾病預(yù)防控制所免疫規(guī)劃中心;軍事交通學(xué)院;軍事經(jīng)濟(jì)學(xué)院襄陽(yáng)士官學(xué)校;海軍工程大學(xué);空軍勤務(wù)學(xué)院;武警部隊(duì)學(xué)院;
【分類號(hào)】：R824.2

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