【摘要】：目的評(píng)估100千伏管電壓結(jié)合低濃度對(duì)比劑的CT模擬定位圖像質(zhì)量及放療靶區(qū)勾畫準(zhǔn)確率,探討低碘、低輻射放療CT模擬定位技術(shù)的應(yīng)用價(jià)值。方法將60例臨床確診非小細(xì)胞性肺癌(NSCLC)且未行手術(shù)切除的患者進(jìn)行CT模擬定位,并隨機(jī)分為兩組:A組為標(biāo)準(zhǔn)組(n=30)使用管電壓120 k V及碘帕醇(370 mg I/ml)進(jìn)行CT掃描;B組為雙低組(n=30)使用管電壓100 k V及碘克沙醇(320 mg I/ml)。對(duì)比劑使用劑量為1.2 ml/kg體重,注射流率3.0 ml/s,使用智能跟蹤法進(jìn)行估算循環(huán)時(shí)間及觸發(fā)掃描。所有圖像均傳輸?shù)絋PS工作站由兩位高年資放療醫(yī)師獨(dú)立進(jìn)行大體腫瘤體積(GTV)勾畫,計(jì)算兩位醫(yī)師所勾畫的GTV差值,對(duì)照兩組的GTV差值是否有統(tǒng)計(jì)學(xué)差異,并對(duì)照兩組患者的碘攝入量、對(duì)比噪聲比(CNR)、有效輻射劑量(ED)及對(duì)比劑不良反應(yīng)發(fā)生率。結(jié)果60例NSCLC患者均能被準(zhǔn)確勾畫出放療靶區(qū),兩組患者的GTV差值差異無(wú)統(tǒng)計(jì)學(xué)意義,肺動(dòng)脈強(qiáng)化程度及CNR差異亦無(wú)統(tǒng)計(jì)學(xué)意義;A組患者的ED及碘攝入量高于B組[(5.64±0.38)m Sv vs(3.49±0.49)m Sv,P0.05;(28.51±3.52)g I vs(23.44±3.05)g I,P0.05];A組患者的對(duì)比劑輕度不良事件發(fā)生率高于B組患者(23.33%vs 10.00%)。結(jié)論使用100千伏和碘克沙醇320進(jìn)行放療CT模擬定位可獲得與120千伏、高濃度碘對(duì)比劑同樣的放療靶區(qū)勾畫準(zhǔn)確率,并能較大幅度降低碘攝入量及ED,具有較高的臨床應(yīng)用價(jià)值。
[Abstract]:Objective to evaluate the quality of CT analog localization images and the accuracy of radiotherapeutic target delineation in 100kV voltage combined with low concentration contrast agent, and to explore the application value of CT simulation localization technique for low iodine and low radiation radiotherapy. Methods A total of 60 patients with non-small cell lung cancer (NSCLC) who were diagnosed clinically as non-small cell lung cancer (NSCLC) and were not surgically resected were studied by CT simulation. They were randomly divided into two groups: group A (standard group) received CT scanning with 120kV tube voltage and iodipaol (370 mg I/ml) and group B (double low group (NN30) used 100kV tube voltage and 320 mg I/ml iodoxol). The dose of contrast agent was 1. 2 ml/kg body weight and the injection flow rate was 3. 0 ml/s,. The cycle time and trigger scan were estimated by intelligent tracking method. All the images were transmitted to TPS workstation. The gross tumor volume (GTV) was drawn by two senior radiotherapeutic physicians independently. The GTV difference between the two doctors was calculated. Whether there was statistical difference in GTV difference between the two groups, there was no statistical difference between the two groups. Iodine intake, (ED) and adverse reaction rate were compared between the two groups. Results all of the 60 patients with NSCLC were able to draw the target area of radiotherapy accurately. The difference of GTV between the two groups was not statistically significant. The ED and iodine intake of group A was higher than that of group B [(5.64 鹵0.38) m Sv vs (3.49 鹵0.49) m Sv,P0.05; (28.51 鹵3.52) g I vs (23.44 鹵3.05) g Igna P0.05], and the incidence of mild adverse events of contrast agent in group A was higher than that in group B (23.33%vs 10.00%). Conclusion using 100kV and iodoxacin 320 for radiotherapy CT simulation localization can obtain the same radiotherapeutic target delineation accuracy as 120kV and high concentration iodine contrast agent, and can greatly reduce iodine intake and ED, has higher clinical application value.
【作者單位】： 廣東省人民醫(yī)院放射治療科CT定位室;
【分類號(hào)】：R734.2;R730.55

【參考文獻(xiàn)】

相關(guān)期刊論文 前8條

1 呂仁鋒;劉婷婷;李超;陶芳;;能譜CT雙低劑量在下肢動(dòng)脈CTA中的應(yīng)用研究[J];放射學(xué)實(shí)踐;2014年04期

2 鄭淑梅;高波;韓彥玲;申秀芬;閻文穎;周志學(xué);;等滲造影劑碘克沙醇在CT增強(qiáng)掃描中的臨床應(yīng)用觀察[J];哈爾濱醫(yī)科大學(xué)學(xué)報(bào);2007年05期

3 曹慧萍;蔡鴻懿;孫金芳;張蓮;劉志學(xué);李敏;;低劑量掃描在肺癌CT模擬定位中的價(jià)值[J];中國(guó)臨床醫(yī)學(xué);2011年03期

4 張?jiān)?萬(wàn)業(yè)達(dá);何岸葦;傅菲;王楠;;不同管電壓下周圍結(jié)構(gòu)對(duì)CT值測(cè)量影響的研究[J];天津醫(yī)科大學(xué)學(xué)報(bào);2013年03期

5 王w藁，

本文編號(hào)：2280595