發(fā)布時間：2018-08-03 15:54

【摘要】：核受體Rev-erbs是能量穩(wěn)態(tài)調(diào)控的核心轉(zhuǎn)錄調(diào)節(jié)因子,其表達(dá)受飲食、藥物、運動等因素的影響;Rev-erbs參與糖脂代謝、胰島素分泌、血糖穩(wěn)態(tài)調(diào)節(jié)等多個生物學(xué)過程,是肥胖癥、糖尿病等慢性代謝性疾病治療的重要藥物靶標(biāo),通過調(diào)節(jié)糖脂代謝通路中的靶分子,調(diào)控組織的能量穩(wěn)態(tài)。運動干預(yù)刺激肝臟、骨骼肌等組織中Rev-erbs表達(dá),調(diào)控糖脂代謝基因,維持細(xì)胞能量穩(wěn)態(tài),可能是慢性病運動干預(yù)的重要適應(yīng)機制。簡述了Rev-erbs的結(jié)構(gòu)特點、表達(dá)調(diào)控因素與作用機制,分析了運動干預(yù)對Rev-erbs表達(dá)的影響與代謝調(diào)控機制,以及Rev-erbs在運動科學(xué)領(lǐng)域的國際前沿和發(fā)展趨勢。
[Abstract]:Nuclear receptor Rev-erbs is the core transcription regulator regulated by energy homeostasis. Its expression is affected by diet, drugs, exercise and other factors. Rev-erbs is involved in many biological processes, such as glucose metabolism, insulin secretion, blood glucose homeostasis, etc. It is obesity. Important drug targets for the treatment of chronic metabolic diseases such as diabetes regulate the energy homeostasis of tissues by regulating the target molecules in the glycolipid metabolic pathway. Exercise intervention can stimulate the expression of Rev-erbs in liver, skeletal muscle and other tissues, regulate the glucose and lipid metabolism genes, and maintain the homeostasis of cell energy, which may be an important adaptive mechanism of chronic disease exercise intervention. In this paper, the structure characteristics, expression regulation factors and action mechanism of Rev-erbs were briefly introduced, and the effects of exercise intervention on Rev-erbs expression and metabolic regulation mechanism were analyzed, as well as the international frontier and development trend of Rev-erbs in the field of sports science.
【作者單位】： 湖北第二師范學(xué)院體育學(xué)院;南印第安納大學(xué)運動科學(xué)系;
【基金】：湖北省自然科學(xué)基金項目(2015CFC881) 湖北省教育廳科學(xué)研究計劃項目(B2016220)
【分類號】：R87
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本文編號：2162233