【摘要】：在電離輻射事故發(fā)生后，對大量輻射暴露人群進行迅速、準確地傷情分類對于傷員的早期治療和事故的定級都非常重要。本文采用基于核函數(shù)的非線性偏最小二乘方法，從劑量效應(yīng)和時間效應(yīng)兩個方面，考察了急性電離輻射對大鼠血漿中氨基酸代謝的影響，，并通過遺傳算法篩選出若干輻射損傷估計指標。結(jié)果表明，輻射后5h，對無輻射暴露的傷情分類正確率達到92.3%，篩選出6個輻射損傷估計指標：Arg, Phe, Gln, Thr, Ile, Cit；輻射后24h，不同程度輻射損傷的傷情分類正確率都在84%以上，篩選出5個輻射損傷估計指標：Tyr, Gln, Hyp, Thr,Leu；輻射后72h的分類效果最佳，不同程度輻射損傷的傷情分類正確率均達到了90%以上，篩選出8個輻射損傷估計指標：Trp, Cy2, Phe, Asn, Gly, Lys, Cit,Orn。研究表明，基于核函數(shù)的非線性偏最小二乘方法相較線性偏最小二乘方法模型解釋能力和預(yù)測能力均有較大提高，更適合于分析關(guān)系復雜的大鼠血漿氨基酸數(shù)據(jù)，有助于提高傷情分類的速度和準確度。
[Abstract]:After the accident of ionizing radiation, it is very important for the early treatment of the wounded and the classification of the accident to classify the injury situation quickly and accurately for a large number of people exposed to radiation. The effects of acute ionizing radiation on the metabolism of amino acids in plasma of rats were investigated in terms of dose effect and time effect by using nonlinear partial least square method based on kernel function. Some indexes of radiation damage estimation were screened by genetic algorithm. The results showed that the correct rate of classification of injuries without radiation exposure reached 92.3% at 5 h after radiation, and the correct classification rate of different degrees of radiation damage was more than 84% by screening out six radiation damage indexes: 1: Arg, 24 h after Phe, Gln, Thr, Ile, Cit; radiation. Five radiation damage estimation indexes: 1) Tyr, Gln, Hyp, ThrrLeu, 72h after radiation, the classification accuracy rate of different degrees of radiation damage were above 90%, and 8 radiation damage estimation indexes: TRP, Cy2, Phe, Asn, Gly, Lys, Citry Orn. were screened out. The results show that the nonlinear partial least squares method based on kernel function is better than the linear partial least squares method in interpretation and prediction, and is more suitable for analyzing the plasma amino acid data of rats with complex relationship. It helps to improve the speed and accuracy of injury classification.
【學位授予單位】：蘇州大學
【學位級別】：碩士
【學位授予年份】：2013
【分類號】：R818;O212.1

【參考文獻】

相關(guān)期刊論文 前4條

1 褚小立,袁洪福,王艷斌,陸婉珍;遺傳算法用于偏最小二乘方法建模中的變量篩選[J];分析化學;2001年04期

2 王國慶,邵學廣;離散小波變換-遺傳算法-交互檢驗法用于近紅外光譜數(shù)據(jù)的高倍壓縮與變量篩選[J];分析化學;2005年02期

3 李華昌,謝淑蘭,易忠勝;遺傳算法的原理與應(yīng)用[J];礦冶;2005年01期

4 湯新星;顧源;蔡尚;徐美玲;王暢;;固相萃取-高效液相色譜-電噴霧串聯(lián)質(zhì)譜技術(shù)分析大鼠血漿中的氨基酸及其在電離輻射損傷動物模型中的應(yīng)用[J];色譜;2012年07期

相關(guān)碩士學位論文 前1條

1 湯新星;氨基酸靶標分析用于急性輻射損傷早期傷情分類的初步研究[D];蘇州大學;2012年

本文編號：2154794