本文選題：Kartogenin + 腱-骨愈合　； 參考：《山東醫(yī)藥》2017年16期

【摘要】：交叉韌帶斷裂、肩袖損傷等肌腱損傷是常見的運(yùn)動損傷,腱-骨連接結(jié)構(gòu)愈合是其治療關(guān)鍵,但其愈合困難是目前臨床一大難題。促進(jìn)腱-骨愈合是修復(fù)肌腱損傷、防止再撕裂的關(guān)鍵,但是目前還沒有能有效、持續(xù)促進(jìn)肌腱損傷修復(fù)術(shù)后腱-骨連接結(jié)構(gòu)恢復(fù)的方法。應(yīng)用各種來源的干細(xì)胞及細(xì)胞因子等生物治療方法在促進(jìn)腱-骨愈合方面受到了廣泛關(guān)注,其中骨髓間充質(zhì)干細(xì)胞(BMSCs)是研究的熱點。小分子化合物Kartogenin(KGN)被發(fā)現(xiàn)能夠顯著誘導(dǎo)BMSCs向軟骨分化,具有極強(qiáng)的促進(jìn)軟骨形成和腱-骨愈合作用,且與藥物釋放系統(tǒng)整合后能更好的發(fā)揮效能。本文就KGN修復(fù)軟骨、促進(jìn)腱-骨愈合方面的研究作一綜述,為臨床上促進(jìn)軟骨修復(fù)、提高腱-骨損傷的治療效果提供新思路。
[Abstract]:Tendon injuries such as cruciate ligament rupture and rotator cuff injury are common sports injuries. The healing of tendon-bone junction structure is the key to its treatment, but the difficulty of healing is a major clinical problem at present. Promoting tendon-bone healing is the key to repair tendon injury and prevent further tear, but there is no effective method to promote the recovery of tendon-bone junction structure after tendon injury repair. The application of stem cells and cytokines has attracted much attention in the field of tendon-bone healing, among which bone marrow mesenchymal stem cells (BMSCs) are the focus of research. Kartogenin (KGN), a small molecule compound, has been found to induce the differentiation of BMSCs into cartilage, which can promote cartilage formation and tendon-bone healing, and can play a better role when integrated with drug release system. This article reviews the research on the repair of cartilage and the healing of tendon-bone by KGN, which provides a new idea for promoting cartilage repair and improving the therapeutic effect of tendon-bone injury in clinic.
【作者單位】： 解放軍昆明總醫(yī)院;
【基金】：國家自然科學(xué)基金資助項目(81360274) 云南省應(yīng)用基礎(chǔ)研究項目(2014FZ106)
【分類號】：R873

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1 劉亦凡,洪天祿;骨愈合的CT實驗觀察[J];蘇州醫(yī)學(xué)院學(xué)報;2000年01期

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本文編號：2113996