本文選題：重離子治癌 + 輻射自顯影膠片�。� 參考：《清華大學(xué)》2013年碩士論文

【摘要】：本課題的主要目的是尋找一個重離子束治癌時劑量的驗證方法。經(jīng)過前期的考察，選擇使用EBT2膠片，可能會使驗證程序更為簡便、結(jié)果更為準(zhǔn)確。經(jīng)過分析EBT2膠片的一系列特性，從而確定其用于劑量驗證的可行性。 課題首先研究了EBT2膠片的一些特性，這些特性包括感光特性、掃描特性等�；谶@些特性，建立了由EBT2膠片和EPSON10000XL平板掃描儀組成的一套劑量驗證系統(tǒng)，并對該系統(tǒng)的使用方法做了更詳細(xì)的研究。分別研究了該系統(tǒng)的組成、校準(zhǔn)、掃描膠片的操作方法、以及掃描后圖像的存儲、圖像的分析，，像素值的提取、轉(zhuǎn)換為絕對劑量等。通過以上研究我們明確了該系統(tǒng)的使用方法及流程，得到了操作規(guī)范，為之后的研究奠定了基礎(chǔ)。 其次利用上述系統(tǒng)對EBT2膠片對重離子束的響應(yīng)特性做了深入的研究，主要研究EBT2膠片的能量響應(yīng)特性和劑量響應(yīng)特性。選取3種不同能量的重離子束照射EBT2膠片后發(fā)現(xiàn)，響應(yīng)曲線大約成指數(shù)關(guān)系，用一個經(jīng)驗公式的最小二乘法擬合曲線，得到曲線特性參數(shù)，結(jié)果發(fā)現(xiàn)EBT2膠片對重離子束的能量響應(yīng)沒有差異。通過嚴(yán)格的標(biāo)定膠片的凈光密度值和絕對劑量，得到EBT2膠片對重離子束的劑量響應(yīng)特性，發(fā)現(xiàn)凈光密度與絕對劑量不是成線性關(guān)系，用一個3次多項式即可很好地擬合這個曲線。由擬合曲線即可很方便的將拍攝到的膠片的光密度值轉(zhuǎn)換為絕對劑量。 通過研究我們發(fā)現(xiàn)，使用EBT2膠片配合EPSON10000XL平板掃描儀組成的劑量驗證系統(tǒng)，來對重離子治癌的劑量驗證是可行的，并且操作便捷、結(jié)果精確。
[Abstract]:The main purpose of this project is to find a method to verify the dose of a heavy ion beam for cancer treatment. After a preliminary investigation, the selection of EBT2 film may make the verification program more convenient and more accurate. After analyzing a series of characteristics of EBT2 film, the feasibility of its dose verification is determined.
Firstly, some characteristics of EBT2 film are studied. These characteristics include photosensitive and scanning characteristics. Based on these characteristics, a set of dose verification system composed of EBT2 film and EPSON10000XL plate scanner is established, and the use method of the system is studied in more detail. The composition, calibration and scanning of the system are studied respectively. The operation method of the film, the storage of the image after scanning, the analysis of the image, the extraction of the pixel value, and the conversion to the absolute dose. Through the above study, we have made clear the method and process of the system, and got the operation specification, which laid the foundation for the later research.
Secondly, the response characteristics of the heavy ion beam on EBT2 film are deeply studied by using the above system. The energy response characteristics and the dose response characteristics of the EBT2 film are mainly studied. The response curves of 3 kinds of heavy ion beams with different energy are selected and the response curve is about exponential relation, and the least square method of an empirical formula is used to fit the curve. It is found that the energy response of the EBT2 film has no difference to the heavy ion beam. By strictly calibrating the net light density and absolute dose of the film, the dose response characteristic of the EBT2 film to the heavy ion beam is obtained. It is found that the net light density is not linear with the absolute dose, and the 3 polynomial can be good. Fitting the curve, it is easy to convert the optical density of photographic film to absolute dose by fitting curve.
Through the study, we found that the dose verification system composed of EBT2 film and EPSON10000XL plate scanner is feasible for the dose verification of heavy ion cancer treatment, and the operation is convenient and the result is accurate.
【學(xué)位授予單位】：清華大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2013
【分類號】：R730.55

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