本文選題：慢性阻塞性肺疾病 + 雙能量��； 參考：《揚(yáng)州大學(xué)》2017年碩士論文

【摘要】：第一部分雙源CT雙能量肺灌注成像自動(dòng)定量評(píng)估對(duì)COPD患者與正常者對(duì)照性研究目的探討雙源CT雙能量肺灌注成像自動(dòng)定量評(píng)估對(duì)COPD患者與正常者之間是否具有差異性。材料與方法18例未見異常者為對(duì)照組;62例COPD患者:結(jié)合2015版慢性阻塞性肺疾病全球倡議(GOLD)按嚴(yán)重程度分組,將COPD患者分為四組(GOLD Ⅰ組15例,GOLD Ⅱ組 18 例,GOLD Ⅲ組 17 例,GOLD Ⅳ組 12 例)。使用 Siemens Syngo.via工作站肺雙能量軟件進(jìn)行自動(dòng)定量分析全肺及局域肺灌注相對(duì)增強(qiáng)值。應(yīng)用SPSS20.0統(tǒng)計(jì)分析軟件處理數(shù)據(jù)。計(jì)量資料用均數(shù)±標(biāo)準(zhǔn)差(x±s)表示。組間比較采用方差分析,均數(shù)間兩兩比較采用LSD法(最小顯著差異法)。P≤0.05為差異有統(tǒng)計(jì)學(xué)意義。結(jié)果對(duì)照組局域肺灌注相對(duì)增強(qiáng)值與COPD各組差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。對(duì)照組全肺灌注相對(duì)增強(qiáng)值與COPD各組差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。其中GOLD Ⅰ組全肺相對(duì)增強(qiáng)值與GOLD Ⅲ組、GOLD Ⅳ組間差異有統(tǒng)計(jì)學(xué)意義;GOLD Ⅱ組全肺相對(duì)增強(qiáng)值與GOLD Ⅲ組、GOLD Ⅳ組間差異有統(tǒng)計(jì)學(xué)意義;GOLD Ⅲ組全肺相對(duì)增強(qiáng)值與GOLD Ⅳ組間差異有統(tǒng)計(jì)學(xué)意義(P0.05)。GOLD Ⅰ組全肺相對(duì)增強(qiáng)值與GOLD Ⅱ組間差異無統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論雙源CT雙能量肺灌注成像的全肺及局域肺灌注相對(duì)增強(qiáng)值對(duì)COPD患者與正常者之間有明顯差異,雙源CT雙能量肺灌注定量評(píng)估可用來區(qū)分COPD患者和正常者,可以評(píng)價(jià)COPD肺實(shí)質(zhì)破壞嚴(yán)重程度。第二部分雙源CT雙能量肺灌注成像對(duì)COPD患者自動(dòng)定量評(píng)估及其與肺功能、肺氣腫指數(shù)相關(guān)性研究目的 探討雙源CT雙能量肺灌注成像自動(dòng)定量分析肺灌注相對(duì)增強(qiáng)值與肺功能檢查參數(shù)、肺氣腫指數(shù)的關(guān)系,評(píng)估COPD全肺及區(qū)域肺功能。材料與方法 對(duì)于62例COPD患者進(jìn)行雙源CT雙能量肺灌注增強(qiáng)掃描及肺功能檢查。通過Siemens Syngo.via工作站肺雙能量軟件進(jìn)行自動(dòng)定量分析全肺及區(qū)域肺灌注相對(duì)增強(qiáng)值及肺氣腫指數(shù)。使用肺功能檢測(cè)儀獲得肺功能參數(shù),測(cè)定的主要指標(biāo)有用力肺活量(FVC)、用力呼氣第1秒量(FEV1)、第1秒用力呼氣量占用力肺活量之比(FEV1/FVC),用力呼氣第1秒量的實(shí)測(cè)值與預(yù)測(cè)值的百分比(FEV1/Pred)。應(yīng)用SPSS20.0統(tǒng)計(jì)分析軟件處理數(shù)據(jù)。Pearson相關(guān)分析肺功能參數(shù)與全肺灌注相對(duì)增強(qiáng)值、肺氣腫指數(shù)的相關(guān)性,以及區(qū)域肺相對(duì)增強(qiáng)值與區(qū)域肺氣腫指數(shù)的相關(guān)性,定義P0.05差異有統(tǒng)計(jì)學(xué)意義,計(jì)量資料用均數(shù)±標(biāo)準(zhǔn)差(x±s)表示。結(jié)果 全肺相對(duì)增強(qiáng)值與FEV1(r=0.480,P=0.025)、FEV1%預(yù)計(jì)值(r=0.601,P=0.001)、FVC(r=0.526,P=0.011)、FEV1/FVC(r=0.539,P=0.010)均呈正相關(guān)。全肺肺氣腫指數(shù)與 FEV1(r=-0.574,P=0.004)、FEV1/Pred(r=-0.605,P=0.002)、FVC(r=-0.572,P=0.004)、FEV1/FVC(r=-0.474,P=0.022)均呈負(fù)相關(guān)。全肺相對(duì)增強(qiáng)值與全肺肺氣腫指數(shù)呈負(fù)相關(guān)(r=-0.605,P=0.000)。各區(qū)域肺相對(duì)增強(qiáng)值與對(duì)應(yīng)的區(qū)域肺氣腫指數(shù)中度負(fù)相關(guān)(P0.05)。結(jié)論 COPD患者應(yīng)用雙源CT雙能量肺灌注自動(dòng)定量肺相對(duì)增強(qiáng)值與肺氣腫指數(shù)、肺功能參數(shù)具有相關(guān)性,可用來評(píng)估肺實(shí)質(zhì)破壞及氣道阻塞程度;區(qū)域肺相對(duì)增強(qiáng)值與區(qū)域肺氣腫指數(shù)中度相關(guān),能實(shí)現(xiàn)肺實(shí)質(zhì)破壞區(qū)域和區(qū)域低灌注之間相匹配;COPD患者應(yīng)用雙源CT雙能量肺灌注自動(dòng)定量軟件可快速對(duì)全肺、區(qū)域肺灌注及肺氣腫進(jìn)行獨(dú)立定量評(píng)估。
[Abstract]:The first part of the dual source CT dual energy lung perfusion imaging automatic quantitative assessment of COPD patients and normal subjects to study the purpose of the dual source CT dual energy lung perfusion imaging automatic quantitative assessment of whether there is difference between COPD patients and normal people. Material and methods 18 cases of no abnormality in the control group; 62 cases of COPD patients: combined with 2015 slow plate slow The global initiative for obstructive pulmonary disease (GOLD) was divided into four groups (15 cases in group GOLD I, 18 in group GOLD II, 18 in group GOLD II, 17 in group GOLD III, 12 in group GOLD IV). The relative enhancement of lung and local pulmonary perfusion was quantified using Siemens Syngo.via workstation. Analysis software processing data. The measurement data were expressed with mean standard deviation (x + s). The difference between the groups was compared with the variance analysis. The difference between the average number of 22 and the.P < 0.05 was statistically significant (P0.05) in the control group (P0.05). The results of the comparison between the control group and the control group were statistically significant (P0.05). The relative enhancement of lung perfusion and COPD groups were statistically significant (P0.05). The relative enhancement value of whole lung in group GOLD I was statistically significant between group GOLD III and group GOLD IV; the relative enhancement value of whole lung in group GOLD II and group GOLD III, GOLD IV group was statistically significant; the relative enhancement value of whole lung in GOLD III group and GOLD IV group in group GOLD III group The difference was statistically significant (P0.05), there was no significant difference between the whole lung relative enhancement value and the GOLD II group in the.GOLD I group (P0.05). Conclusion the relative enhancement value of the whole lung and local lung perfusion of dual source CT dual energy lung perfusion imaging has obvious difference between the COPD patients and the normal ones. The dual source CT dual energy lung perfusion quantitative assessment can be used to distinguish COPD. Patients and normal people can evaluate the severity of COPD lung parenchyma damage. Second the automatic quantitative evaluation of COPD patients with dual source CT dual energy perfusion imaging and the correlation of pulmonary function and emphysema index with two source CT dual energy lung perfusion imaging for automatic quantitative analysis of pulmonary perfusion relative enhancement and pulmonary function examination parameters, The relationship between the emphysema index and the pulmonary function of COPD whole lung and region. Materials and methods were used to perform dual source CT dual energy lung perfusion enhanced scan and lung function examination in 62 patients with COPD. The pulmonary and pulmonary perfusion relative enhancement value and emphysema index of the whole lung and region were quantitatively analyzed by the lung dual energy software of Siemens Syngo.via workstation. Pulmonary function testing instrument obtained the parameters of lung function. The main indexes were forced vital capacity (FVC), forced expiration 1 second (FEV1), 1 second forced expiratory volume (FEV1/FVC), the measured value of forced expiration 1 second and the percentage of predicted values (FEV1/Pred). SPSS20.0 statistical analysis software was used to deal with the data.Pearson correlation. The relative enhancement of pulmonary function parameters and whole lung perfusion, the correlation of emphysema index, the correlation between regional pulmonary emphysema and regional pulmonary emphysema index, the difference between the P0.05 and the measured data was statistically significant, and the measurement data were expressed with mean standard deviation (x + s). Results all lung phase contrast enhancement and FEV1 (r=0.480, P=0.025), FEV1% prediction value (r=0) .601, P=0.001), FVC (r=0.526, P=0.011), FEV1/FVC (r=0.539, P=0.010) are all positive correlation. All lung emphysema index and FEV1 (r=-0.574, P=0.004) are negatively correlated. All lung relative enhancement values are negatively correlated with the whole lung emphysema index. The relative enhancement value of the domain lung was negatively correlated with the corresponding regional emphysema index (P0.05). Conclusion the application of dual source CT dual energy lung perfusion in COPD patients with the pulmonary emphysema index and the pulmonary function parameters is related to the assessment of pulmonary parenchyma damage and the degree of airway obstruction; regional pulmonary relative enhancement and regional lung qi. The moderate correlation of the swelling index can match the area of lung parenchyma destruction and regional low perfusion, and COPD patients can quickly evaluate the whole lung, regional pulmonary perfusion and emphysema by the dual source CT dual energy lung perfusion automatic quantitative software.
【學(xué)位授予單位】：揚(yáng)州大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R563.9;R816.41

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 王蕾;楊汀;王辰;;2017年版慢性阻塞性肺疾病診斷、處理和預(yù)防全球策略解讀[J];中國(guó)臨床醫(yī)生雜志;2017年01期

2 王之悅;祝因蘇;陳雪松;劉扣英;唐立鈞;魏永越;;多層螺旋CT肺小血管與肺截面積比值評(píng)價(jià)慢性阻塞性肺疾病嚴(yán)重程度的作用[J];中華放射學(xué)雜志;2016年02期

3 于蒙蒙;白雪冬;陳榮;張迪;季洋;蘇貝爾;王丹;;能譜CT肺灌注成像評(píng)價(jià)不同病理改變肺組織通氣及血流灌注情況[J];中國(guó)臨床醫(yī)學(xué)影像雜志;2014年03期

4 管宇;夏藝;范麗;張鐵峰;劉士遠(yuǎn);李兵;于紅;;COPD不同CT表型的CT灌注表現(xiàn)特征及其與肺功能參數(shù)的相關(guān)性研究[J];臨床放射學(xué)雜志;2013年12期

5 吳山;武志峰;鄂林寧;江小鵬;;第二代雙源CT雙能量成像對(duì)肺栓塞的診斷價(jià)值研究[J];中國(guó)臨床醫(yī)學(xué)影像雜志;2012年11期

6 江杰;何波;張俊;韓丹;;雙源CT雙能量胸部虛擬平掃的應(yīng)用價(jià)值[J];中國(guó)醫(yī)學(xué)影像技術(shù);2012年04期

7 趙晶;潘紀(jì)戍;;COPD表現(xiàn)型的CT定量診斷[J];國(guó)際醫(yī)學(xué)放射學(xué)雜志;2011年03期

8 張龍江;盧光明;;雙能量CT在胸部的應(yīng)用和進(jìn)展[J];中華放射學(xué)雜志;2011年01期

9 張龍江;周長(zhǎng)圣;朱正庭;蔡軍;柴學(xué);趙艷娥;盧光明;;雙源CT雙能量肺灌注成像對(duì)比劑應(yīng)用參數(shù)優(yōu)化及輻射劑量的研究[J];中國(guó)臨床醫(yī)學(xué)影像雜志;2009年09期

10 管宇;張鐵峰;范麗;夏藝;劉士遠(yuǎn);李兵;于紅;;慢性阻塞性肺疾病患者256iCT肺實(shí)質(zhì)灌注成像的定量評(píng)估及與肺功能、氣腫指數(shù)的相關(guān)性研究[J];實(shí)用放射學(xué)雜志;2013年06期

，

本文編號(hào)：2029170