本文選題：參數(shù)優(yōu)化　切入點(diǎn)：定量分析　出處：《華中科技大學(xué)》2012年碩士論文

【摘要】：冠脈造影是檢查心血管疾病的最有效手段，，但其二維成像方式增加了讀片難度并制約定量分析精度。三維重建為臨床診斷與治療提供了新的解決方案，可以提供直觀真實(shí)的冠狀動(dòng)脈空間結(jié)構(gòu)，方便醫(yī)生定位病灶，精確測(cè)量血管參數(shù)。對(duì)造影序列進(jìn)行重建還可以充分挖掘造影圖信息，估計(jì)血管運(yùn)動(dòng)參數(shù)，并研究心臟運(yùn)動(dòng)情況。 本文首先分析了雙視角三維重建原理，分析了影響重建精度的各種因素，提出了能夠滿足后續(xù)分析重建結(jié)果的優(yōu)化方法。為了更好的表達(dá)重建的血管表面，本文拓展了常用的以圓來(lái)描述血管橫截面的廣義圓柱模型，利用參與重建的兩幅造影圖信息，以橢圓來(lái)擬合血管截面，使得重建血管的更加接近真實(shí)形態(tài)。 本文研究了冠狀動(dòng)脈造影定量分析，這包括二維定量分析和三維定量分析。在二維造影圖上計(jì)算了病變血管狹窄程度，在三維重建的基礎(chǔ)上計(jì)算血管長(zhǎng)度、分支夾角、體積等參數(shù)，通過(guò)實(shí)驗(yàn)證明了三維定量分析的準(zhǔn)確性和優(yōu)勢(shì)，實(shí)現(xiàn)了一種基于三維重建結(jié)果選取感興趣血管段近似最佳投影角度的方法。利用可視化開(kāi)發(fā)工具VTK，實(shí)現(xiàn)了交互式定量分析模塊。 在造影圖序列重建的基礎(chǔ)上定性和定量分析了冠狀動(dòng)脈的運(yùn)動(dòng)特點(diǎn)。提出了對(duì)重建序列求局部運(yùn)動(dòng)的方法，以豐富冠狀動(dòng)脈模型運(yùn)動(dòng)信息。
[Abstract]:Coronary angiography is the most effective method to detect cardiovascular disease, but its two-dimensional imaging method increases the difficulty of reading film and restricts the accuracy of quantitative analysis.Three-dimensional reconstruction provides a new solution for clinical diagnosis and treatment. It can provide visual and real coronary artery spatial structure, facilitate doctors to locate lesions and accurately measure vascular parameters.The reconstruction of angiography sequence can also fully mine the information of angiogram, estimate the parameters of blood vessel motion, and study the cardiac movement.In this paper, the principle of 3D reconstruction with two angles of view is analyzed, the factors influencing the reconstruction accuracy are analyzed, and an optimization method is proposed to satisfy the reconstruction results of subsequent analysis.In order to better express the reconstructed blood vessel surface, this paper extends the general cylindrical model which describes the cross section of blood vessel by circle, and uses the information of two angiograms which participate in the reconstruction to fit the cross section of blood vessel with ellipse.Make the reconstruction of the blood vessel closer to the true form.The quantitative analysis of coronary arteriography was studied in this paper, including two-dimensional quantitative analysis and three-dimensional quantitative analysis.The degree of vessel stenosis was calculated on two-dimensional angiography, and the parameters of vascular length, angle of branch and volume were calculated on the basis of 3D reconstruction. The accuracy and advantage of 3D quantitative analysis were proved by experiments.A method to select the approximate optimal projection angle of the interested vascular segment based on the 3D reconstruction results is implemented.The interactive quantitative analysis module is realized by using visual development tool VTK.The characteristics of coronary artery motion were qualitatively and quantitatively analyzed on the basis of sequence reconstruction of angiogram.In order to enrich the motion information of coronary artery model, a method of finding local motion for reconstruction sequence is proposed.
【學(xué)位授予單位】：華中科技大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2012
【分類號(hào)】：R816.2

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本文編號(hào)：1700926