本文選題：宮頸癌　切入點(diǎn)：腔內(nèi)放療　出處：《醫(yī)學(xué)與哲學(xué)(B)》2017年01期

【摘要】：回顧性分析局部晚期宮頸癌192Ir腔內(nèi)放療患者的臨床療效、不良反應(yīng)及預(yù)后相關(guān)因素。采集筆者科室30例局部晚期宮頸癌患者,治療上盆腔體外放療(45Gy)聯(lián)合以A點(diǎn)作為劑量參考點(diǎn)的192Ir腔內(nèi)放療,然后將根治性放療的累積總劑量轉(zhuǎn)化為2Gy分次等效生物劑量(EQD2)進(jìn)行計(jì)算評估,三組不同劑量分割組(4Gy/次×10次、5Gy/次×8次、5Gy/次×9次)A點(diǎn)的累積總劑量存在差異,腫瘤大小、A點(diǎn)累積劑量及參考體積是影響局部晚期宮頸癌預(yù)后的相關(guān)因素,其中腫瘤大小及參考體積是影響3年總生存率的獨(dú)立預(yù)后因素,A點(diǎn)的累積劑量與療效、復(fù)發(fā)或轉(zhuǎn)移、不良反應(yīng)及生存情況之間無顯著相關(guān)性。
[Abstract]:The clinical efficacy, adverse reactions and prognostic factors of patients with locally advanced cervical cancer treated with 192Ir intracavitary radiotherapy were retrospectively analyzed. 30 patients with locally advanced cervical cancer were collected from our department. Pelvic extracorporeal radiotherapy (ECRT) combined with 192Ir intracavity radiotherapy with point A as the dose reference point was used to calculate and evaluate the cumulative total dose of radical radiotherapy to 2Gy equivalent biodose (EQD2). The cumulative total dose of point A of 4 Gy / times 脳 10 times / times 脳 8 times / times 脳 9 times was different among the three groups. The cumulative dose and reference volume of tumor site A were related factors to the prognosis of locally advanced cervical cancer. The tumor size and reference volume were independent prognostic factors affecting the overall survival rate of 3 years. There was no significant correlation between the cumulative dose of point A and the curative effect, recurrence or metastasis, adverse reaction and survival condition.
【作者單位】： 大連醫(yī)科大學(xué)附屬第二醫(yī)院腫瘤放療科;宜昌市第二人民醫(yī)院腫瘤放療科;
【分類號】：R737.33;R730.55

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