本文關(guān)鍵詞： 肺部小病灶 劑量學(xué)比較 容積調(diào)強(qiáng) 陀螺刀　出處：《安徽醫(yī)科大學(xué)學(xué)報(bào)》2017年07期 　論文類型：期刊論文

【摘要】：目的分析Co-60陀螺刀和容積調(diào)強(qiáng)(VMAT)治療肺部小病灶劑量學(xué)分布特點(diǎn),比較兩種計(jì)劃在危及器官(OAR)保護(hù)和全身低劑量區(qū)體積大小的差異。方法對48例肺部小病灶患者(含原發(fā)性肺癌及肺轉(zhuǎn)移癌,共56個病灶),分別設(shè)計(jì)陀螺刀和VMAT計(jì)劃,采用劑量體積直方圖對靶區(qū)和OAR劑量學(xué)參數(shù)進(jìn)行評估,并比較兩種計(jì)劃的差異。結(jié)果陀螺刀計(jì)劃的計(jì)劃靶區(qū)平均劑量(PTVDmean),計(jì)劃靶區(qū)最高劑量(PTVDmax),均勻指數(shù),全肺V5、V10和平均受量,患側(cè)肺V5、V10、V20、V30和平均受量均顯著高于VMAT計(jì)劃(P0.05),而VMAT計(jì)劃的靶區(qū)適形指數(shù),健側(cè)肺V5、V10和平均受量,脊髓最大受量,心臟和脊髓平均受量均顯著高于陀螺刀計(jì)劃(P0.05)。結(jié)論陀螺刀計(jì)劃和VMAT計(jì)劃在治療肺部小病灶時均能達(dá)到腫瘤靶區(qū)劑量要求和正常組織劑量約束;陀螺刀計(jì)劃優(yōu)勢是PTVDmean,健側(cè)肺組織受量低;而VMAT計(jì)劃優(yōu)勢為腫瘤靶區(qū)適形度高,全肺及患側(cè)肺V5、V10和平均受量低。
[Abstract]:Objective to analyze the dosimetric distribution of Co-60 gyroscope knife and volume modulated intensity modulation (VIMT) in the treatment of small pulmonary lesions. Methods 48 patients with small pulmonary lesions (including primary lung cancer and metastatic lung cancer) with 56 lesions were selected to design gyroscope knife and VMAT program respectively. Dose volume histogram was used to evaluate the dosimetry parameters of target area and OAR, and the difference between the two plans was compared. Results the average dose of planned target area of gyroscope knife plan was mean, the maximum dose of planned target area was maxum, uniform index, whole lung V5 / V10 and mean dose. The V5 / V10 / V20 / V30 and average uptake of the affected lung were significantly higher than that of the VMAT plan (P 0.05), while the conformal index of the target area of the VMAT program, the V5 / V10 of the normal lung and the mean dose of V20 / V30 were significantly higher than those of the VMAT plan (P < 0. 05). The mean dose of heart and spinal cord was significantly higher than that of gyroscope knife plan P0.05.Conclusion both gyro knife planning and VMAT plan can meet the target dose requirements and normal tissue dose constraints in the treatment of small pulmonary lesions. The advantage of gyroscope planning was that PTV was mean, and that of healthy lung tissue was low, while that of VMAT was high conformability of tumor target area, low V5 V10 and average recipient of whole lung and affected lung.
【作者單位】： 安徽醫(yī)科大學(xué)第一附屬醫(yī)院放療科;安徽醫(yī)科大學(xué)附屬省立醫(yī)院;安徽省腫瘤醫(yī)院放療科;
【基金】：中華國際醫(yī)學(xué)交流基金會先聲抗腫瘤治療專項(xiàng)科研基金(編號:Z-2014-06-16355) 安徽省高校省級自然科學(xué)研究項(xiàng)目基金(編號:KJ2010B380)
【分類號】：R730.55;R734.2

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