本文關(guān)鍵詞： 美沙拉秦 宮頸癌 急性放射性直腸炎　出處：《青海大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

【摘要】：目的:研究美沙拉秦片劑結(jié)合栓劑使用在子宮頸癌放射治療過程中預(yù)防急性放射性直腸炎的療效觀察。方法:選取本院腫瘤婦科從2015年01月到2016年09月收住的子宮頸癌行同步放化療病患56例,行三維適形放射治療,隨機將這些病患分成觀察組和對照組各28例。觀察組從放療開始至放療結(jié)束,口服美沙拉秦腸溶片(莎爾福)及美沙拉秦栓(莎爾福)塞肛,具體用法為片劑,1.0 g/次,早、中、晚各一次,栓劑早晚塞肛,0.5 g/次,2次/日。對照組不采取防治手段。若觀察組和對照組病患發(fā)現(xiàn)有Ⅱ度或者超過Ⅱ度癥狀時將地塞米松、慶大霉素、蒙脫石散、三乙醇胺乳膏睡前保留灌腸,癥狀消失后停止使用。將患者血便、里急后重、腹痛、腹瀉狀況詳細記錄下來,根據(jù)記錄下來的數(shù)據(jù)探討所有入選病患急性放射性直腸炎發(fā)生率、發(fā)生時間、發(fā)生程度和保留灌腸的次數(shù),并予以比對。結(jié)果:1.觀察組有11人(39.29%)發(fā)生急性放射性直腸炎,對照組有21人(75.00%)發(fā)生,兩組比較,前者人數(shù)較少,P=0.040.05,有統(tǒng)計學(xué)差異。2、觀察組急性放射性直腸炎發(fā)生程度為0度17例,I度5例,II度6例,III度及IV度0例,對照組發(fā)生程度0度7例,I度9例,II度11例,III度1例,IV度0例。P=0.040.05,有統(tǒng)計學(xué)差異。3.觀察組急性放射性直腸炎發(fā)生時間(18.18士4.19天),對照組發(fā)生時間(14.48士3.95天),兩者相比,前者較晚,P=0.0190.05,有統(tǒng)計學(xué)差異。4.觀察組保留灌腸人數(shù)有(3.00±0.775)次,對照組(4.00±1.414)次,兩者相比,前者較少,P=0.0150.05,有統(tǒng)計學(xué)差異。結(jié)論:美沙拉秦口服結(jié)合栓劑使用可使急性放射性直腸炎的發(fā)生率降低,減輕急性放射性直腸炎的發(fā)生程度,并使其發(fā)生時間延后。
[Abstract]:Objective: to study the therapeutic effect of mesalazin tablet combined with suppository in the prevention of acute radiation proctitis during radiotherapy for cervical cancer. Methods: select the tumor gynecology from January 2015 to September 2016 in our hospital. 56 patients with cervical cancer received concurrent radiotherapy and chemotherapy. Three dimensional conformal radiotherapy was performed. These patients were randomly divided into two groups: the observation group (n = 28) and the control group (n = 28). The specific usage was as follows: tablet 1.0 g / time, morning, middle and late, and suppositories in the morning and evening. The control group did not take preventive measures. If the patients in the observation group and the control group found symptoms of degree 鈪，

本文編號：1498152