低水平母源性十溴聯(lián)苯醚暴露對子鼠學(xué)習(xí)記憶能力和甲狀腺激素影響
[Abstract]:Aim to observe the effects of low-level maternal exposure to decabromodiphenyl ether (BDE209) on learning and memory ability and thyroid hormone secretion in offspring. Methods after mating successfully, female Kunming mice of 4 weeks of age without specific pathogen were randomly divided into two groups: control group (n = 16) and low, middle and high dose group (n = 16). The female rats in the control group were fed with 0. 01 L/kg body weight peanut oil. According to the body weight of 50100 渭 g / kg and 300 渭 g / kg, the female rats in the control group were intragastrically administrated with BDE209,1 per day for 21 days, and the exposure model from pregnancy to lactation was established. After exposure, 10 male and female rats in each group were randomly selected to observe their body mass and development, and the learning and memory ability of each group was tested by water maze test. The serum levels of total triiodothyronine (TT3), free triiodothyronine (FT3), total tetraiodothyronine (TT4) and free tetraiodothyronine (FT4) were measured by chemiluminescence immunoassay. The activities of glutathione transferase (GST), superoxide dismutase (SOD) and malondialdehyde (MDA) in hippocampus were measured by colorimetric method. Results the escape latency of the middle exposure group was longer than that of the control group (P0.05), and the escape latency of the high exposure group was longer than that of the control group and low, respectively (P0.05). The time of platform quadrant activity and the times of crossing the platform in the high exposure group were shorter than those in the control group and low, respectively (P0.05). With the increase of exposure dose, the levels of TT3,FT3,TT4 and FT4 in serum increased gradually (P0.05), and the activities of GST and SOD in hippocampus decreased gradually (P0.05), MDA level gradually increased (P0.05). Conclusion low level of maternal BDE209 can decrease the learning and memory ability of offspring and increase the level of serum thyroid hormone in a dose-dependent manner. There is a dose-dependent oxidative stress injury in hippocampus.
【作者單位】： 桂林醫(yī)學(xué)院公共衛(wèi)生學(xué)院;桂林醫(yī)學(xué)院組織胚胎學(xué)教研室;
【基金】：國家自然科學(xué)基金(81560530) 2016年廣西自治區(qū)大學(xué)生科技創(chuàng)新項目(201610601085)
【分類號】：R114
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