發(fā)布時(shí)間：2018-12-10 18:07

【摘要】：目的了解柯薩奇病毒A組6型、腸道病毒71型和柯薩奇A組16型手足口病流行特征、臨床特點(diǎn),為指導(dǎo)臨床診斷,調(diào)整手足口病防控策略提供科學(xué)依據(jù)。方法采用前瞻性調(diào)查的方法,采集2013年8月至2015年9月在北京市兒童醫(yī)院診斷的手足口病臨床確診病例的咽拭子,將手足口病原核酸檢測(cè)陽(yáng)性的病例分為CA6、EV71、CA16 3組,分析比較3組的臨床特點(diǎn)、流行特征、預(yù)后及影響因素。結(jié)果共采集HFMD臨床診斷病例574例患兒咽拭子,CA6入組122例,EV71入組107例,CA16入組124例。13組年齡、性別分布一致,差異無(wú)統(tǒng)計(jì)學(xué)意義。2不同年份流行主要毒株不同,但3種病原體引起的手足口病高峰均在夏季。3CA6組發(fā)熱比例高達(dá)78.69%,明顯高于EV71組(35.51%)和CA16組(37.90%)(P0.001),平均體溫約為38.78℃。CA6組表現(xiàn)大皰疹(9.01%)、結(jié)痂(8.20%)、皮疹部位疼痛(29.51%)、恢復(fù)期脫皮(38.52%)、脫甲(35.25%)、色素沉著(11.47%)比例高于EV71組、CA16(P0.001)。43組在衛(wèi)生學(xué)指標(biāo)方面差異無(wú)統(tǒng)計(jì)學(xué)意義。結(jié)論CA6、EV71和CA16感染所致的HFMD發(fā)病高峰季節(jié)一致;與EV71、CA16感染相比,CA6感染引起的高熱比例較高,部分病例可表現(xiàn)為大皰疹,疼痛、脫皮、脫甲、色素沉著、結(jié)痂發(fā)生率高,預(yù)后較好。
[Abstract]:Objective to investigate the epidemic characteristics and clinical characteristics of coxsackievirus A group 6, enterovirus 71 and coxsackie A group 16 hand, foot and mouth disease, and to provide scientific basis for guiding clinical diagnosis and adjusting prevention and control strategy of hand, foot and mouth disease. Methods the pharyngeal swabs of clinically diagnosed HFMD cases diagnosed in Beijing Children's Hospital from August 2013 to September 2015 were collected by prospective investigation. The patients with HFMD were divided into three groups: CA6,EV71,CA16 group. The clinical characteristics, epidemic characteristics, prognosis and influencing factors of the three groups were analyzed and compared. Results throat swabs of 574 children with HFMD were collected, including 122 cases of CA6, 107 cases of EV71 and 124 cases of CA16. However, the peak of HFMD caused by the three pathogens occurred in summer. The febrile rate in 3CA6 group was 78.69, which was significantly higher than that in EV71 group (35.51%) and CA16 group (37.90%) (P0.001). The average body temperature was about 38.78 鈩，

本文編號(hào)：2370992