【摘要】：幼體動(dòng)物早期斷奶后,由于食物成分、生活環(huán)境、心理等方面的變化,會(huì)產(chǎn)生一系列的應(yīng)激反應(yīng),稱(chēng)之為斷奶應(yīng)激綜合征。斷奶應(yīng)激會(huì)誘使幼體動(dòng)物出現(xiàn)生長(zhǎng)發(fā)育緩慢,腸道菌群失衡,體內(nèi)代謝紊亂等癥狀,嚴(yán)重者危及生命。本實(shí)驗(yàn)通過(guò)研究不同劑量低聚乳果糖對(duì)早期斷奶大鼠生長(zhǎng)性能、糞便理化性質(zhì)和腸道菌群以及大鼠體內(nèi)內(nèi)源性代謝物的影響來(lái)探究低聚乳果糖對(duì)斷奶大鼠機(jī)體代謝的作用機(jī)制,同時(shí)為低聚乳果糖在斷奶應(yīng)激綜合征上的應(yīng)用提供一定的理論依據(jù)。 實(shí)驗(yàn)結(jié)果表明,在實(shí)驗(yàn)第一周時(shí),對(duì)斷奶大鼠補(bǔ)充高劑量低聚乳果糖不但不能有效緩解斷奶應(yīng)激反應(yīng),還會(huì)加重機(jī)體自身的應(yīng)激反應(yīng),而低劑量組大鼠各項(xiàng)檢測(cè)指標(biāo)明顯優(yōu)于對(duì)照組和高劑量組,說(shuō)明大鼠對(duì)低聚乳果糖的補(bǔ)充也需要一個(gè)適應(yīng)的過(guò)程；在實(shí)驗(yàn)第二周時(shí),補(bǔ)充高劑量低聚乳果糖能顯著提高斷奶大鼠的體重增長(zhǎng)率,提高大鼠的表觀蛋白消化率和氮存留率；顯著降低糞便pH值和NH3-N含量,提高大鼠糞便中短鏈脂肪酸含量,對(duì)腸道雙歧桿菌和乳酸桿菌具有明顯的增殖作用；并通過(guò)影響大鼠體內(nèi)內(nèi)源性代謝物來(lái)調(diào)控大鼠機(jī)體的能量代謝和免疫功能,從而有效地緩解斷奶應(yīng)激造成的各種損傷。 綜上所述,對(duì)斷奶大鼠補(bǔ)充低聚乳果糖可以有效地緩解斷奶應(yīng)激造成的損傷,并提高大鼠對(duì)斷奶應(yīng)激的抵抗作用。
[Abstract]:After early weaning young animals will produce a series of stress reactions due to the changes of food composition living environment and psychology which are called weaning stress syndrome. Weaning stress can induce young animals to develop slowly, intestinal flora imbalance, metabolic disorders and other symptoms, serious life-threatening. By studying the effects of different doses of oligosaccharide on growth performance, fecal physicochemical properties, intestinal flora and endogenous metabolites in early weaning rats, the mechanism of fructose oligosaccharide on metabolism of weaned rats was investigated. At the same time, it provides some theoretical basis for the application of oligosaccharide in weaning stress syndrome. The results showed that during the first week of the experiment, feeding high dose fructose to weaning rats could not only alleviate the stress response of weaning, but also aggravate the stress response of the body itself. However, the low dose group was superior to the control group and the high dose group, indicating that the supplement of fructose oligosaccharide also needed a process of adaptation. In the second week of the experiment, high dose of fructose could significantly increase the growth rate of body weight, apparent protein digestibility and nitrogen retention of weaned rats. The pH value and NH3-N content in feces were significantly decreased, and the short chain fatty acid content in feces of rats was increased, and the proliferation of bifidobacterium and Lactobacillus in the intestinal tract was obvious. The energy metabolism and immune function of rats were regulated by affecting endogenous metabolites in rats, which effectively alleviated all kinds of damage caused by weaning stress. In conclusion, supplementation of fructooligosaccharide to weaning rats can effectively alleviate the damage caused by weaning stress and increase the resistance of rats to weaning stress.
【學(xué)位授予單位】：南昌大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2013
【分類(lèi)號(hào)】：R151.2

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