【摘要】：探討吸煙成癮者戒煙前后的腦功能活動(dòng)差異,使用3.0T磁共振掃描儀采集14名吸煙成癮者戒煙前和戒煙后的靜息態(tài)MRI數(shù)據(jù),采用低頻振幅(amplitude of low-frequency fluctuation,ALFF)的方法來(lái)比較分析吸煙成癮者在戒煙前和戒煙兩周后的腦功能活動(dòng)情況。與戒煙前相比,吸煙成癮者戒煙兩周后靜息狀態(tài)下的右側(cè)楔前葉、右側(cè)后扣帶回、左側(cè)緣上回、左側(cè)背外側(cè)額上回和左側(cè)額中回的ALFF活動(dòng)降低;雙側(cè)距狀裂周?chē)�、雙側(cè)楔葉、左側(cè)中央后回和左側(cè)中央旁小葉的ALFF活動(dòng)增加。研究結(jié)果表明:吸煙成癮者在戒煙兩周后額葉、邊緣葉、頂葉和枕葉腦區(qū)的腦功能活動(dòng)發(fā)生了改變,提示ALFF可作為監(jiān)測(cè)或評(píng)價(jià)戒煙效果的潛在生理指標(biāo)。
[Abstract]:To explore the difference of brain function before and after smoking cessation, the resting MRI data of 14 smokers before and after smoking cessation were collected by 3.0T magnetic resonance imaging (MRI). The low frequency amplitude (amplitude of low-frequency fluctuation,ALFF method was used to compare and analyze the brain function of smokers before and two weeks after smoking cessation. The activity of ALFF in the right prewedge lobe, the right posterior cingulate gyrus, the left superior marginal gyrus, the left dorsolateral superior frontal gyrus and the left middle frontal gyrus decreased after two weeks of smoking cessation, and the bilateral cortex around the talar fissure, the right posterior cingulate gyrus, the left dorsolateral superior frontal gyrus and the left middle frontal gyrus. The ALFF activity in bilateral cuneate lobe, left posterior central gyrus and left paracentral lobules increased. The results showed that the brain function of the frontal lobe, marginal lobe, parietal lobe and occipital lobe were changed after smoking cessation for two weeks, suggesting that ALFF could be used as a potential physiological index to monitor or evaluate the effect of smoking cessation.
【作者單位】： 桂林電子科技大學(xué)生命與環(huán)境科學(xué)學(xué)院;
【基金】：國(guó)家科技支撐計(jì)劃資助項(xiàng)目(2013BAI03B01) 國(guó)家自然科學(xué)基金資助項(xiàng)目(61271119) 廣西自然科學(xué)基金資助項(xiàng)目(CXNSFBA380145) 廣西省高等學(xué)校科學(xué)研究資助項(xiàng)目(KY2015YB096) 2015年廣西信息科學(xué)實(shí)驗(yàn)中心資助項(xiàng)目(YB1513)
【分類(lèi)號(hào)】：R163;R445.2

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