【摘要】：目的探討職業(yè)性慢性苯中毒患者染色體損傷情況及其可能的影響因素。方法采用方便抽樣法,以50例職業(yè)性慢性苯中毒患者為慢性苯中毒組,以53名無職業(yè)接觸苯及其他有毒物質(zhì)的工人為對(duì)照組。對(duì)研究對(duì)象進(jìn)行問卷調(diào)查和血常規(guī)檢測(cè),采用胞質(zhì)分裂阻滯微核法進(jìn)行微核率檢測(cè)。結(jié)果慢性苯中毒組患者周圍血紅細(xì)胞計(jì)數(shù)、血紅蛋白水平、白細(xì)胞計(jì)數(shù)、血小板計(jì)數(shù)、淋巴細(xì)胞計(jì)數(shù)和中性粒細(xì)胞計(jì)數(shù)均低于對(duì)照組(P0.01),淋巴細(xì)胞微核率高于對(duì)照組(均值:6.26‰vs 3.91‰,P0.01),微核率偏高的比例高于對(duì)照組(46.0%vs 5.7%,P0.01);多因素Poisson回歸分析結(jié)果顯示,在排除性別、年齡、吸煙、飲酒和職業(yè)性苯接觸工齡的影響后,脫離苯接觸年限是慢性苯中毒組患者微核率的影響因素(P0.05)。結(jié)論職業(yè)性慢性苯中毒可導(dǎo)致患者淋巴細(xì)胞染色體損傷增加;脫離苯接觸時(shí)間與染色體損傷呈正相關(guān)。
[Abstract]:Objective to investigate the chromosome damage and its possible influencing factors in occupational chronic benzene poisoning patients. Methods 50 patients with occupational chronic benzene poisoning and 53 workers without occupational exposure to benzene and other toxic substances were used as control group. The subjects were investigated by questionnaire and blood routine, and the micronucleus rate was detected by cytokinesis block micronucleus method. Results Peripheral blood red blood cell count, hemoglobin level, white blood cell count, platelet count in chronic benzene poisoning group, The lymphocyte count and neutrophil count were lower than that of the control group (P0.01), the micronucleus rate of lymphocytes was higher than that of the control group (mean: 6.26 鈥，

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