本文選題：乳桿菌制劑 + 陰道微生態(tài)評(píng)價(jià)　； 參考：《吉林大學(xué)》2013年碩士論文

【摘要】：目的：通過(guò)對(duì)我院婦科門診就診的陰道炎患者及健康體檢者，進(jìn)行陰道分泌物檢測(cè)和陰道微生態(tài)評(píng)價(jià)，分析陰道微生態(tài)平衡的影響因素，調(diào)查陰道微生態(tài)失調(diào)的檢出率、各種陰道炎癥的構(gòu)成比等，并根據(jù)陰道微生物檢測(cè)及微生態(tài)評(píng)價(jià)結(jié)果，探討微生態(tài)療法在女性陰道炎癥治療中的臨床價(jià)值，為預(yù)防陰道炎癥的發(fā)生和降低陰道炎癥的復(fù)發(fā)，提供更好的方法。 方法：將2012年9月至2013年3月間，就診于我院婦科門診的陰道炎患者、健康體檢者總計(jì)1560例，作為研究對(duì)象,以體檢結(jié)合問(wèn)卷調(diào)查的形式對(duì)每一位調(diào)查對(duì)象進(jìn)行陰道分泌物檢測(cè)和陰道微生態(tài)評(píng)價(jià)，統(tǒng)計(jì)出陰道微生態(tài)失調(diào)的檢出情況，各種陰道炎癥的構(gòu)成情況；同時(shí)，對(duì)于患有陰道炎癥的患者，依據(jù)自愿原則，在治療上分別采取抗（真）菌藥組及抗（真）菌藥+乳桿菌制劑組，比較并分析兩組的治療效果（治愈率、復(fù)發(fā)率）；對(duì)于只存在微生態(tài)失調(diào)而無(wú)陰道感染的患者，同樣依據(jù)自愿分為兩組，即干預(yù)組和未干預(yù)組，比較兩組的患病情況。 結(jié)果： 1.1560例調(diào)查對(duì)象中，陰道微生態(tài)失調(diào)者1089例，失調(diào)檢出率為69.81%。1089例陰道微生態(tài)失調(diào)患者中，892例患陰道炎癥，197例無(wú)陰道炎癥狀，，感染罹患率為81.91%。其余471例婦女，陰道微生態(tài)正常。 2.892例陰道炎構(gòu)成情況：?jiǎn)渭僔VC335例，占37.56%；單純BV267例，占29.93%；單純TV189例，占21.19%；混合感染101例，占11.32%。 3.668例無(wú)陰道感染者陰道微生態(tài)評(píng)價(jià)結(jié)果：微生態(tài)正常471例，占70.51%；微生態(tài)失調(diào)197例，占29.49%。 4.兩種不同方法治療陰道炎效果比較：（7天、14天的治愈率，3個(gè)月的復(fù)發(fā)率） 1）單純VVC：抗真菌藥組170例，抗真菌藥+乳桿菌制劑組165例：7天治愈率分別為87.65%和91.52%，P0.05，差異無(wú)統(tǒng)計(jì)學(xué)意義；14天治愈率分別為94.71%和99.39%，P0.05，差異有統(tǒng)計(jì)學(xué)意義；3個(gè)月復(fù)發(fā)率分別為13.53%和3.03%，P0.01，差異有統(tǒng)計(jì)學(xué)意義。 2）單純BV：抗菌藥組134例，抗菌藥+乳桿菌制劑組133例：7天治愈率分別為90.30%和98.50%，P0.01，差異有統(tǒng)計(jì)學(xué)意義；14天治愈率分別為98.51%和100.00%，P0.05，差異無(wú)統(tǒng)計(jì)學(xué)意義；3個(gè)月復(fù)發(fā)率分別為8.96%和0.00%，P0.01，差異有統(tǒng)計(jì)學(xué)意義。 3）單純TV：抗菌藥組98例，抗菌藥+乳桿菌制劑組91例：7天治愈率分別為92.86%和100.00%，P0.05，差異有統(tǒng)計(jì)學(xué)意義；14天治愈率分別為97.96%和100.00%，P0.05，差異無(wú)統(tǒng)計(jì)學(xué)意義；3個(gè)月復(fù)發(fā)率分別為10.20%和0.00%，P0.01，差異有統(tǒng)計(jì)學(xué)意義。 4）混合感染：抗(真)菌藥組49例，抗(真)菌藥+乳桿菌制劑組52例，7天治愈率分別為69.39%和88.46%；P0.05，差異有統(tǒng)計(jì)學(xué)意義；14天治愈率分別為93.88%和100.00%；P0.05，差異無(wú)統(tǒng)計(jì)學(xué)意義；3個(gè)月復(fù)發(fā)率分別為26.53%和3.85%；P0.01，差異有統(tǒng)計(jì)學(xué)意義。 5.微生態(tài)制劑對(duì)于陰道微環(huán)境的調(diào)節(jié)：對(duì)首次檢查無(wú)陰道炎的197例陰道微生態(tài)失調(diào)者中，95例接受了預(yù)防性干預(yù)（乳桿菌組），102例未接受干預(yù)。干預(yù)組在干預(yù)后的3個(gè)月，行陰道分泌物檢測(cè)，有16人患陰道炎，（分別為VVC9例、BV4例，TV3例，無(wú)混合感染），發(fā)病率為16.84%；未干預(yù)組，在同一時(shí)間行陰道分泌物，有35例患陰道炎癥，（其中VVC16例，BV11例，TV7例，混合感染１例）發(fā)病率34.31%；P0.01，差異有統(tǒng)計(jì)學(xué)意義。 結(jié)論: 1.陰道微生態(tài)失調(diào)是各種陰道炎的重要影響因素。 2.外陰陰道假絲酵母菌病和細(xì)菌性陰道病是最常見(jiàn)陰道炎。 3.部分正常婦女也存在陰道微生態(tài)失調(diào)。 4.乳桿菌制劑能夠增加治療各種陰道炎藥物的療效。 5.乳桿菌制劑用于調(diào)節(jié)陰道微環(huán)境，可以預(yù)防各種陰道炎的發(fā)生。
[Abstract]:Objective: through the examination of vagina secretion and the microecological evaluation of vagina, the influence factors of vaginal microecological balance were analyzed, the detection rate of vagina microecological imbalance and the composition ratio of various vaginitis were investigated, and the results were based on the vaginal microorganism detection and microecological evaluation. To explore the clinical value of microecological therapy in the treatment of female vaginitis, and to provide a better way to prevent the occurrence of vaginitis and to reduce the recurrence of vaginitis.
Methods: from September 2012 to March 2013, a total of 1560 cases of vaginitis in the gynecologic outpatient department of our hospital were treated with a total of 1560 cases. As a study object, the detection of vaginal secretions and the vaginal microecological evaluation were carried out in the form of physical examination and questionnaire investigation, and the detection of vaginal microecological disorders was found. At the same time, for the patients with vaginitis, according to the voluntary principle, the anti (true) bacteria medicine group and the anti (true) drug + lactobacillus preparation group were adopted respectively, and the treatment effect (cure rate, recurrence rate) of the two groups was compared and analyzed, and the patients with only microecological disorder but no vaginal infection were also based on the same basis. They were voluntarily divided into two groups, namely, intervention group and non intervention group. The prevalence of two groups was compared.
Result:
Among the 1.1560 cases, 1089 cases of vagina microecologic maladjustment were found in 69.81%.1089 cases, 892 cases were vaginitis, 197 had no vaginitis, the infection rate was the other 471 cases of 81.91%., and the vagina microecology was normal.
2.892 cases of vaginitis constitute: simple VVC335 cases, accounting for 37.56%; simple BV267 cases, accounting for 29.93%; simple TV189 cases, accounting for 21.19%; mixed infection 101 cases, accounting for 11.32%.
Results of vaginal microecological evaluation in 3.668 cases without vaginal infection: 471 cases of Microecology were normal, accounting for 70.51%, and 197 cases of microecological imbalance, accounting for 29.49%.
4. comparison of two different treatments for vaginitis: (7 days, 14 days cure rate, 3 months recurrence rate)
1) simple VVC: antifungal drug group 170 cases, antifungal drugs + lactobacillus preparation group 165 cases: 7 days cure rate was 87.65% and 91.52%, P0.05, the difference was not statistically significant; 14 days cure rate was 94.71% and 99.39%, P0.05, the difference was statistically significant; 3 months recurrence rate was 13.53% and 3.03%, P0.01, the difference was statistically significant.
2) simple BV: 134 cases of antibacterial drug group and 133 cases of antibacterial + lactobacillus preparation group: 7 days cure rate was 90.30% and 98.50%, P0.01, the difference was statistically significant; 14 days cure rate was 98.51% and 100%, P0.05, the difference was not statistically significant; 3 months recurrence rate was 8.96% and 0%, P0.01, the difference was statistically significant.
3) simple TV: 98 cases of antibacterial drug group and 91 cases of antibacterial + lactobacillus preparation group: 7 days cure rate was 92.86% and 100%, P0.05, the difference was statistically significant; 14 days cure rate was 97.96% and 100%, P0.05, the difference was not statistically significant; 3 months recurrence rate was 10.20% and 0%, P0.01, the difference was statistically significant.
4) mixed infection: 49 cases of anti (true) bacteria medicine group, 52 cases of anti (true) bacteria and Lactobacillus preparation group, 7 days cure rate was 69.39% and 88.46%, P0.05, the difference was statistically significant; 14 days cure rate was 93.88% and 100%, respectively, the difference was not statistically significant; 3 months relapse rate was 26.53% and 3.85%, respectively, P0.01, the difference was statistically significant.
5. the regulation of microecologic agents for vaginal microenvironment: of the 197 cases of vagina microecoecology for the first time without vaginitis, 95 cases received preventive intervention (Lactobacillus group) and 102 unaccepted intervention. In the intervention group, vaginal secretions were detected in 3 months, and 16 patients were infected with vaginitis (VVC9 cases, BV4 cases, TV3 cases, no mixture, respectively). Infection), the incidence rate was 16.84%; the vaginal secretions were performed at the same time and 35 cases of vaginitis were found at the same time. (among them VVC16, BV11, TV7, and mixed infection 1 cases), the incidence rate was 34.31%, and the difference was statistically significant.
Conclusion:
1. the imbalance of vaginal microecology is an important factor affecting vaginitis.
2. vulvovaginal candidiasis and bacterial vaginosis are the most common vaginitis.
The 3. part of normal women also has vaginal microecological imbalance.
4. lactobacillus preparation can increase the curative effect of various vaginitis drugs.
5. lactobacillus preparation can be used to regulate vaginal microenvironment and prevent the occurrence of various vaginitis.
【學(xué)位授予單位】：吉林大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2013
【分類號(hào)】：R173

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 廖秦平;吳文湘;;女性陰道微生態(tài)評(píng)價(jià)體系的臨床應(yīng)用[J];中國(guó)婦產(chǎn)科臨床雜志;2010年03期

2 廖秦平;張岱;;中國(guó)女性生殖道感染診治現(xiàn)狀及研究進(jìn)展[J];國(guó)際婦產(chǎn)科學(xué)雜志;2011年06期

3 李響;;陰道微生態(tài)平衡及其臨床意義[J];吉林醫(yī)學(xué);2010年36期

4 劉朝暉;廖秦平;;外陰陰道念珠菌病高發(fā)區(qū)與低發(fā)區(qū)患者的流行病學(xué)研究[J];中國(guó)全科醫(yī)學(xué);2006年08期

5 吳美娟;;13,570例細(xì)菌性陰道病檢測(cè)結(jié)果分析[J];生殖醫(yī)學(xué)雜志;2008年06期

6 高文;陳琢;;乳桿菌對(duì)維持陰道微生態(tài)平衡的作用機(jī)理[J];現(xiàn)代婦產(chǎn)科進(jìn)展;2008年05期

7 劉朝暉;張岱;趙敏;王穎;白會(huì)會(huì);肖冰冰;廖秦平;;5236例健康婦女陰道微生態(tài)狀況的分析[J];現(xiàn)代婦產(chǎn)科進(jìn)展;2009年02期

8 王哲蔚;朱麗萍;王國(guó)琴;姚劍峰;高曉玲;周蕾;;已婚婦女常見(jiàn)生殖道感染現(xiàn)狀及干預(yù)措施研究[J];中國(guó)婦幼保健;2008年23期

9 朱崇云;;陰道微生態(tài)特性及影響因素[J];中國(guó)婦幼保健;2012年05期

10 戴鐘英;陰道生態(tài)平衡和免疫[J];中國(guó)實(shí)用婦科與產(chǎn)科雜志;2005年03期

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