本文選題：同位素內(nèi)標 + 液質(zhì)聯(lián)用�。� 參考：《現(xiàn)代預防醫(yī)學》2017年03期

【摘要】：目的建立液質(zhì)聯(lián)用同位素內(nèi)標法同時測定豬肉中硝西泮、氯硝西泮、氟硝西泮、奧沙西泮、勞拉西泮、阿普唑侖、替馬西泮、地西泮的方法。方法在均質(zhì)的豬肉樣品中添加同位素內(nèi)標地西泮-d5,經(jīng)乙腈提取后用全自動固相萃取儀凈化,液相色譜質(zhì)譜聯(lián)用儀檢測,內(nèi)標法定量。結果苯二氮卓類鎮(zhèn)靜劑藥物在線性范圍內(nèi)具有良好的線性關系,線性相關性r≥0.999,檢出限在0.030μg/kg~0.096μg/kg之間,加標回收率在89.8%-114.6%之間,相對標準偏差在2.45%~7.92%之間。結論該方法靈敏度高、回收率好,適用于豬肉中多種苯二氮卓類鎮(zhèn)靜劑藥物殘留的同時檢測。
[Abstract]:Objective to establish a method for simultaneous determination of nitrazepam, clonazepam, flunitrazepam, oxazepam, lorazepam, alprazolam, temazepam and diazepam in pork by liquid-mass spectrometry. Methods the isotopic diazepam d5 was added to the homogenized pork samples. After extraction by acetonitrile, it was purified by automatic solid-phase extraction instrument, detected by liquid chromatography-mass spectrometry (LC-MS), and measured by internal standard method. Results the linear range of benzodiazepines was linear, the linear correlation was r 鈮，

本文編號：2040358