本文選題：維生素D + 甲狀旁腺素��； 參考：《中國(guó)學(xué)校衛(wèi)生》2017年03期

【摘要】：目的了解廣州市兒童維生素D水平及其與甲狀旁腺素(PTH)的關(guān)系,為減少兒童維生素D缺乏性疾病的發(fā)生和改善兒童骨骼健康提供科學(xué)依據(jù)。方法采用橫斷面研究,對(duì)2015年廣州市某婦幼保健院健康體檢的976名兒童進(jìn)行體格檢查,采集空腹靜脈血,用化學(xué)發(fā)光法檢測(cè)血清25-羥維生素D[25(OH)D]和甲狀滂腺素(PTH)。結(jié)果兒童血清25(OH)D平均水平為(90.67±36.55)nmol/L,其中男童為(90.14±34.89)nmol/L,女童為(91.33±38.58)nmol/L,差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。維生素D缺乏率及不足率分別為11.37%和25.31%,性別間差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。不同年齡兒童血清25(OH)D水平差異有統(tǒng)計(jì)學(xué)意義(F=55.547,P0.05),血清25(OH)D水平隨年齡增長(zhǎng)呈下降趨勢(shì)。不同年齡兒童維生素D營(yíng)養(yǎng)狀況差異有統(tǒng)計(jì)學(xué)意義(χ2=87.352,P0.05),維生素D缺乏率及不足率隨年齡增長(zhǎng)而升高(χ2趨勢(shì)=68.909,P0.05)。兒童血清PTH平均水平為(2.38±1.29)pmol/L,維生素D缺乏及不足兒童血清PTH水平均高于維生素D充足兒童,差異有統(tǒng)計(jì)學(xué)意義(F=10.427,P0.05)。血清25(OH)D水平與PTH呈負(fù)相關(guān)(r=-0.149,P=0.000)。結(jié)論廣州市0~16歲兒童維生素D缺乏率及不足率較高,年長(zhǎng)兒童維生素D營(yíng)養(yǎng)狀況較年幼兒童差,血清25(OH)D與PTH水平呈負(fù)相關(guān)。應(yīng)采取合理措施改善兒童維生素D的營(yíng)養(yǎng)狀況。
[Abstract]:Objective to investigate the level of vitamin D and its relationship with PTH in children in Guangzhou, so as to provide scientific basis for reducing the incidence of vitamin D deficiency in children and improving children's bone health. Methods A cross-sectional study was carried out on 976 children who underwent physical examination in a maternal and child health care hospital in Guangzhou in 2015. Fasting venous blood samples were collected, and serum 25-hydroxyvitamin D (25-OHH) and pang glandin (PTH) were detected by chemiluminescence. Results the average serum level of 25 OHH / L in children was 90.67 鹵36.55 nmol / L, 90.14 鹵34.89 nmol / L for boys and 91.33 鹵38.58 nmol / L for girls, respectively. There was no significant difference between them (P 0.05). The rates of vitamin D deficiency and deficiency were 11.37% and 25.31%, respectively. There were significant differences in serum 25 OHH D levels among children of different ages (P 0.05), and the serum 25 OHH D levels decreased with the increase of age. There were significant differences in vitamin D nutritional status among children of different ages (蠂 ~ 2 = 87.352P 0.05). The rate of vitamin D deficiency and deficiency increased with the increase of age (蠂 ~ 2 trend: 68.909 / P 0.05). The average level of serum PTH in children was 2.38 鹵1.29 mmol / L, and the levels of serum PTH in children with vitamin D deficiency and deficiency were higher than those in children with adequate vitamin D, and the difference was statistically significant (P 0.05). There was a negative correlation between serum 25 OHH D and PTH. Conclusion Vitamin D deficiency rate and deficiency rate were higher in 16 year old children in Guangzhou, vitamin D nutritional status of older children was worse than that of young children, and serum 25 OHH D was negatively correlated with PTH level. Reasonable measures should be taken to improve the nutritional status of vitamin D in children.
【作者單位】： 廣東藥科大學(xué)公共衛(wèi)生學(xué)院;廣東省婦幼保健院放射科;
【基金】：地方高校國(guó)家級(jí)大學(xué)生創(chuàng)新創(chuàng)業(yè)訓(xùn)練計(jì)劃項(xiàng)目(201610573001)
【分類(lèi)號(hào)】：R153.2

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