本文選題：大鼠 + 腎臟　； 參考：《中國職業(yè)醫(yī)學(xué)》2017年03期

【摘要】：目的探討不同周齡和性別的SD大鼠腎臟非腫瘤病變發(fā)生情況。方法收集亞急性毒性實(shí)驗(yàn)、亞慢性毒性實(shí)驗(yàn)、1年及2年慢性毒性與致癌合并實(shí)驗(yàn)中空白對(duì)照組的無特定病原體級(jí)SD大鼠800只,按實(shí)驗(yàn)結(jié)束時(shí)大鼠周齡分別分為10、19、56和108周齡組,每組雌、雄大鼠各100只。于各自實(shí)驗(yàn)終末期分別處死大鼠后取腎臟組織,計(jì)算腎臟臟器系數(shù),分析大鼠腎臟非腫瘤性病理改變情況。結(jié)果雌性大鼠腎臟臟器系數(shù)在56、108周齡組均低于10和19周齡組(P0.008);雄性大鼠腎臟臟器系數(shù)在56周齡組分別低于10和19周齡組(P0.008),在108周齡組高于56周齡組(P0.008);108周齡組雄性大鼠腎臟臟器系數(shù)高于108周齡組雌性大鼠(P0.008)。與108周齡組雄性大鼠比較,108周齡組雌性大鼠腎小管鈣鹽沉積、間質(zhì)炎細(xì)胞浸潤及腎小管擴(kuò)張發(fā)生率升高(P0.05),慢性進(jìn)行性腎病發(fā)生率下降(P0.01);56周齡組雌性大鼠腎小管鈣鹽沉積發(fā)生率高于56周齡組雄性大鼠(P0.01)。結(jié)論 SD大鼠腎臟非腫瘤自發(fā)性病變較多見,相同周齡組不同性別大鼠間部分病變的發(fā)生率不同。
[Abstract]:Objective to investigate the incidence of renal non-neoplastic lesions in SD rats of different weeks of age and sex. Methods 800 SD rats with no specific pathogens were collected from subacute toxicity test, subchronic toxicity test, 1 year and 2 years chronic toxicity and carcinogenesis combined experiment. The rats were divided into 10 ~ 1956 and 108 weeks old groups according to the age of the rats at the end of the experiment. There were 100 female and 100 male rats in each group. The renal tissue was taken from the rats at the end stage of each experiment, and the renal organ coefficient was calculated, and the non-neoplastic pathological changes of the kidney of the rats were analyzed. Results the renal organ coefficient of female rats was lower than that of 10 and 19 weeks old group at 56108 weeks old, that of male rats was lower than that of 10 and 19 weeks old group at 56 weeks old group, and that of male rats was higher than that of 56 weeks old group at 10 and 19 weeks old group, and that of male rats was higher than that of 56 weeks old group. The renal organ coefficient of rats was higher than that of female rats at 108 weeks old (P 0.008). The calcium deposition of renal tubules in female rats of 108 weeks old was compared with that of male rats at 108 weeks of age. The incidence of interstitial cell infiltration and tubule dilatation was higher than that of male rats at 56 weeks of age. The incidence of chronic progressive nephropathy was decreased. The incidence of calcium deposition in renal tubules of female rats was higher than that of male rats at 56 weeks old. Conclusion Non-neoplastic spontaneous renal lesions are more common in SD rats, and the incidence of partial lesions is different among different sexes in the same age group.
【作者單位】： 廣東省職業(yè)病防治院廣東省職業(yè)病防治院重點(diǎn)實(shí)驗(yàn)室;
【基金】：廣東省醫(yī)學(xué)科學(xué)技術(shù)研究基金(A2016122) 廣東省職業(yè)病防治重點(diǎn)實(shí)驗(yàn)室(2012A061400007)
【分類號(hào)】：R114

【參考文獻(xiàn)】

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