發(fā)布時(shí)間：2018-05-25 21:30

  本文選題：腸產(chǎn)毒性大腸桿菌 + 疾病暴發(fā)流行　； 參考：《中國(guó)學(xué)校衛(wèi)生》2017年08期

【摘要】：目的探討溫州市洞頭區(qū)某學(xué)校一起由大腸埃希菌O153感染引起的暴發(fā)疫情的流行病學(xué)特征,為類似疫情防控提供技術(shù)支持。方法采用統(tǒng)一的流行病學(xué)個(gè)案調(diào)查表進(jìn)行現(xiàn)場(chǎng)調(diào)查,描述流行特征,采取病例對(duì)照研究探討病因假設(shè),采集患者、食堂工作人員的肛拭標(biāo)本進(jìn)行病原微生物培養(yǎng),采用多重PCR技術(shù)確定毒力基因。結(jié)果 2016年10月16—31日,1 256名學(xué)生和教職工中累計(jì)發(fā)現(xiàn)病例126例,罹患率為10.03%(126/1 256),無重癥和死亡病例�；颊叩呐R床表現(xiàn)為腹瀉(≥3次/d)(100.00%),伴有腹痛(84.13%)、惡心(27.78%)、嘔吐(13.49%)、發(fā)熱(7.14%)等癥狀。學(xué)生、教師不同食堂就餐罹患率差異有統(tǒng)計(jì)學(xué)意義(χ~2=0.24,P=0.01)。病例對(duì)照研究提示飲用學(xué)生食堂未燒開的水是此次暴發(fā)疫情的危險(xiǎn)因素(OR=5.33,χ~2=10.33,P=0.00),病原微生物培養(yǎng)和多重PCR技術(shù)毒力基因鑒定確認(rèn)為腸產(chǎn)毒大腸埃希菌O153感染。結(jié)論本次疫情為由腸產(chǎn)毒大腸埃希菌O153引起學(xué)校感染性腹瀉暴發(fā),病例分布呈現(xiàn)明顯的聚集性,發(fā)病曲線呈持續(xù)性暴露,飲用學(xué)生食堂未燒開的水是危險(xiǎn)因素。建議學(xué)校嚴(yán)格執(zhí)行因病缺課登記,完善校醫(yī)制度,做好食堂衛(wèi)生和飲用水管理。
[Abstract]:Objective to investigate the epidemiological characteristics of an outbreak caused by Escherichia coli O153 infection in a school in Dongtou District of Wenzhou City in order to provide technical support for the prevention and control of similar outbreaks. Methods A unified epidemiological case questionnaire was used to investigate the epidemic characteristics. The etiological hypothesis was investigated by case-control study. The anal swab specimens of patients and staff in canteen were collected for culturing pathogenic microorganisms. The virulence gene was identified by multiplex PCR. Results A total of 126 cases were found in 1 256 students and teaching staff from October 16 to 31, 2016, with an attack rate of 10.03126 / 1256. There were no severe or fatal cases. The clinical manifestations of the patients were diarrhea (鈮，

本文編號(hào)：1934719