本文選題：麻腮風(fēng)聯(lián)合減毒活疫苗 + 兒童��； 參考：《中國疫苗和免疫》2017年04期

【摘要】：目的觀察國產(chǎn)麻腮風(fēng)聯(lián)合減毒活疫苗(MMR)在5歲兒童復(fù)種和育齡期女性接種的免疫效果和安全性。方法選擇在8月齡已接種1劑次麻疹疫苗且在18-24月齡已接種1劑次MMR的5歲健康兒童以及孕前體檢風(fēng)疹抗體陰性的育齡期女性接種MMR。采集所有觀察對象MMR接種前及接種后1個(gè)月血標(biāo)本,采用酶聯(lián)免疫吸附試驗(yàn)(ELISA)檢測麻疹、風(fēng)疹和流行性腮腺炎(流腮)Ig G抗體,隨訪觀察疫苗接種后的疑似預(yù)防接種異常反應(yīng)(AEFI)。結(jié)果 158名5歲兒童MMR接種前麻疹、風(fēng)疹和流腮抗體陽性率分別為95.57%、89.87%和82.91%,接種后分別為100%、99.37%和100%;接種后抗體幾何平均濃度(GMC)分別是接種前的1.65倍、1.70倍和4.02倍。育齡期女性MMR接種前麻疹、風(fēng)疹和流腮抗體陽性率分別為80.49%(33/41)、0.00%(0/38)和82.93%(34/41),接種后分別為100%(41/41)、84.21%(32/38)和100%(41/41);接種后GMC分別是接種前的1.82倍、14.05倍和3.03倍。所有觀察對象接種MMR后均未出現(xiàn)AEFI。結(jié)論國產(chǎn)MMR在兒童復(fù)種和育齡期女性接種有良好的免疫效果和安全性。推薦開展兒童2劑次MMR常規(guī)免疫和孕前體檢風(fēng)疹抗體陰性的育齡期女性接種MMR。
[Abstract]:Objective to observe the immunological efficacy and safety of MMRs combined with leprosy and attenuated live vaccine in children of 5 years old and women of childbearing age. Methods 5 years old healthy children who had been vaccinated with 1 dose of measles vaccine at the age of 8 months and 1 dose of MMR at the age of 18 to 24 months and women of childbearing age who had negative rubella antibody before pregnancy were inoculated with MMRs. All blood samples were collected before and 1 month after inoculation of MMR. Measles, rubella and mumps (gills Ig) antibodies were detected by enzyme linked immunosorbent assay (Elisa). Results the positive rates of measles, rubella and gills antibody were 95.57% and 82.91%, 100% and 100% after inoculation, respectively, and the geometric mean concentration of antibody after inoculation was 1.65 times 1.70 times and 4.02 times of that before inoculation, respectively. The positive rates of measles, rubella and gills antibody were 80.49% and 82.93% / 34 / 41% before inoculation, respectively, and the positive rates of measles, rubella and gills antibody were 80.49% and 82.93% / 34 / 41 before inoculation, respectively, and the GMC after inoculation were 1.82 times 14.05 times and 3.03 times higher than those before inoculation, and the positive rates of measles, rubella and gills after inoculation were 1.82 times, 14.05 times and 3.03 times, respectively. AEFI was not found in all subjects after inoculation with MMR. Conclusion domestic MMR has good immune effect and safety in children and women of childbearing age. Two doses of MMR routine immunization and rubella antibody negative in pre-pregnancy examination for children were recommended to be inoculated with MMRs in women of childbearing age.
【作者單位】： 天津市疾病預(yù)防控制中心;東麗區(qū)疾病預(yù)防控制中心;寧河區(qū)疾病預(yù)防控制中心;中國疾病預(yù)防控制中心免疫規(guī)劃中心;中國生物技術(shù)集團(tuán)公司;
【分類號】：R186

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