本文選題：酪蛋白 + 小麥面筋蛋白�。� 參考：《衛(wèi)生研究》2015年03期

【摘要】：目的探討不同水平下的酪蛋白和小麥面筋蛋白對血漿同型半胱氨酸(Hcy)水平的影響。方法健康Wistar大鼠48只隨機分為6組,分別為12.5%、25%、50%酪蛋白組和14.5%、29%、58%小麥面筋蛋白組。大鼠自由進食、飲水,每天稱重并記錄大鼠進食量。喂養(yǎng)實驗飼料14天后處死,采集血液,取肝臟組織,用于測定血漿和肝臟中Hcy、半胱氨酸(Cys)等氨基酸指標以及同型半胱氨酸甜菜堿甲基轉移酶(BHMT)和胱硫醚β-合成酶(CBS)等酶學指標。結果小麥面筋蛋白組的大鼠體重增長顯著低于酪蛋白組,而在小麥面筋蛋白組隨著蛋白含量的提高,大鼠的飼料攝入量明顯逐漸減少。小麥面筋蛋白的攝入使血漿Hcy濃度顯著低于酪蛋白組,相反血漿Cys的濃度,小麥蛋白組明顯高于酪蛋白組。結論小麥面筋蛋白對血漿Hcy水平的影響主要取決于高Cys與低蛋氨酸含量,但是其賴氨酸和蘇氨酸含量較低也是不能忽視的影響因素之一。其主要的作用機制是Cys的升高促進了Hcy代謝的酶活性,增加了Hcy的代謝消耗。
[Abstract]:Objective to investigate the effects of casein and wheat gluten on plasma homocysteine (Hcy) levels. Methods Forty-eight healthy Wistar rats were randomly divided into 6 groups, 12.5% casein group and 14.5% wheat gluten group. Rats ate freely, drank water, weighed and recorded their food intake every day. After 14 days of feeding, the rats were killed, blood was collected and liver tissues were taken. The indexes of amino acids such as Hcyl, cysteine methyltransferase (Hcy) and cysteine betaine methyltransferase (BHMT) and cystathionine 尾 -synthase (CBS) were determined. Results the weight gain of the wheat gluten group was significantly lower than that of the casein group, but the diet intake of the wheat gluten group gradually decreased with the increase of protein content. The plasma Hcy concentration was significantly lower in wheat gluten group than that in casein group. On the contrary, the plasma Cys concentration in wheat protein group was significantly higher than that in casein group. Conclusion the effect of wheat gluten on plasma Hcy level mainly depends on the high Cys and low methionine content, but the low lysine and threonine content is one of the factors that can not be ignored. The main mechanism is that the increase of Cys promotes the enzyme activity of Hcy metabolism and increases the metabolic consumption of Hcy.
【作者單位】： 中國疾病預防控制中心營養(yǎng)與健康所營養(yǎng)與代謝研究室;日本靜岡大學應用生物化學系;
【基金】：中國營養(yǎng)學會營養(yǎng)科研基金-帝斯曼專項科研基金(No.2014-059) 日本學術振興會(JSPS)基礎研究(C)(No.19580135)
【分類號】：R151

【共引文獻】

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