本文選題：美藤果油 + 改善記憶　； 參考：《食品科學(xué)》2017年09期

【摘要】：目的:通過(guò)小鼠實(shí)驗(yàn)探討美藤果油改善記憶功能的作用。方法:72只雄性SPF級(jí)昆明小鼠隨機(jī)分為空白組,模型組,美藤果油低、中、高劑量組(375.1、750.2、1 500.0 mg/(kg·d),以體質(zhì)量計(jì),下同)及深海魚(yú)油組(1 500.0 mg/kg)。連續(xù)給藥30 d后,進(jìn)行避暗、跳臺(tái)、Morris水迷宮實(shí)驗(yàn)。結(jié)果:美藤果油750.2、1 5 0 0.0 mg/(k g·d)劑量組能劑量依賴(lài)性地顯著延長(zhǎng)模型小鼠避暗和跳臺(tái)實(shí)驗(yàn)的潛伏期,減少錯(cuò)誤次數(shù)(P0.05),而對(duì)Morris水迷宮測(cè)試中的潛伏期及游泳路程百分比無(wú)顯著影響。結(jié)論:美藤果油在375.1~1 500.0 mg/(kg·d)的劑量范圍內(nèi)可能具有輔助改善小鼠記憶功能的作用。
[Abstract]:Objective: to study the effect of malleol on memory function in mice.Methods Seventy-two male Kunming mice of SPF grade were randomly divided into blank group, model group, low, medium and high dose group (375.1750.2 ~ 1 500.0 mg/(kg DX) and deep-sea fish oil group (1 500.0 mg 路kg ~ (-1) 路kg ~ (-1) ~ (-1) mg 路kg ~ (-1)).After 30 days of continuous administration, the water maze test was carried out.Results: the dose group of 750.2 and 1500.0 mg/(k / d could significantly prolong the latency of dark avoidance and platform jumping test in model mice in a dose-dependent manner, and reduce the number of errors (P0.05), but had no significant effect on the latency and the percentage of swimming distance in Morris water maze test.Conclusion: in the range of 375.1 ~ 1 ~ (-1) mg/(kg ~ (-1) mg/(kg ~ (-1) ~ (-1) ~ (-1) mg/(kg ~ (-1) ~ (-1) ~ (-1) ~ (-1) mg/(kg ~ (-1),
【作者單位】： 沈陽(yáng)藥科大學(xué)生命科學(xué)與生物制藥學(xué)院;
【分類(lèi)號(hào)】：R151
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本文編號(hào)：1741640